Test Price
2,800 AED✅ Home Collection Available
FERMT3 Gene (Leukocyte Adhesion Deficiency Type 3) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 certified NGS processing with full copy number variant detection.
- Premium Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across all Emirates.
- Clinical Guidance: Telephonic post-test guidance for result interpretation and genetic counselling coordination with a consultant medical geneticist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) panel analyses the entire coding region and splice sites of the FERMT3 gene, which encodes kindlin-3—a protein critical for leukocyte adhesion and platelet aggregation. Pathogenic variants in FERMT3 cause Leukocyte Adhesion Deficiency Type 3 (LAD3), a rare autosomal recessive primary immunodeficiency characterised by recurrent infections, bleeding tendency, and impaired wound healing. Early genetic confirmation enables timely referral for hematopoietic stem cell transplantation, the only curative therapy currently available.
| Feature | Our NGS Test (Premium) | Closest Alternative (Targeted Sanger) |
|---|---|---|
| Precision | 99.9% analytical sensitivity for SNPs, indels, and CNVs | ~95% for known point mutations only |
| Methodology | NGS with full copy number variant detection across entire FERMT3 gene | Bidirectional Sanger sequencing, limited to selected exons |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
Physician Insight & Safety Protocols
“Every FERMT3 result must be interpreted within the full clinical context—including bleeding time, complete blood count, and a three-generation family pedigree. This NGS panel detects pathogenic and likely pathogenic variants with high analytical sensitivity, but it does not replace a multidisciplinary diagnostic workup. A positive finding can empower families to pursue curative options such as hematopoietic stem cell transplantation, while a negative result does not exclude all causes of leukocyte adhesion deficiency. Pre-test and post-test genetic counselling are essential.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety & Clinical Advisory
Do not discontinue or adjust prescribed prophylactic antibiotics, corticosteroids, or anti-fibrinolytic therapy without explicit direction from your managing specialist. Genetic test results provide diagnostic clarification but do not override acute clinical judgment. All sample collection, consent, and result disclosure procedures adhere to the standards set forth in Federal Decree-Law No. 4 of 2016 on Medical Liability.
Exclusion Criteria & Emergency Red Flags
- Do not schedule phlebotomy during an active febrile illness or systemic infection.
- If spontaneous bruising, petechiae, or mucous membrane bleeding appears, halt collection and refer to a paediatric haematologist immediately.
- Seek emergency care if: sudden extensive ecchymosis, persistent epistaxis, or signs of intracranial haemorrhage (severe headache, vomiting, altered consciousness) occur while awaiting results.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the FERMT3 genetic test for suspected leukocyte adhesion deficiency type 3?
This test confirms or excludes a genetic diagnosis of LAD3 by detecting pathogenic variants across the entire FERMT3 gene. With ISO-certified NGS achieving 99.9% diagnostic sensitivity, the result guides definitive management—including hematopoietic stem cell transplantation—and informs family genetic counselling and recurrence risk assessment.
2. How should I prepare my child for the blood collection procedure?
No special preparation is required. The sample collection involves a standard peripheral venipuncture (EDTA whole blood) or a dried blood spot on an FTA card. Ensure the child is well-hydrated and not experiencing any acute febrile illness on the day of collection. Our mobile phlebotomist can perform the draw at home between 8 AM and 11 PM with full cold-chain handling.
3. Will my UAE health insurance cover the cost of this genetic test?
We facilitate direct billing verification with all major UAE insurers. Send a photo of your Emirates ID and insurance card via WhatsApp at +971 54 548 8731 for instant eligibility confirmation and prior-authorisation support. Coverage depends on your policy’s genetic testing and paediatric immunology provisions.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Regulatory Compliance: This diagnostic service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genomic and personal data are encrypted, access-controlled, and processed exclusively within the UAE under the oversight of DHA facility license 1143.
Clinical & Logistical Metadata
| Test Name | FERMT3 Gene (Leukocyte Adhesion Deficiency Type 3) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot on FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with Full Copy Number Variant Detection |
| ICD-10-CM Code | D84.0 |
| LOINC Code | 94222-4 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians