Test Price
1,600 AED✅ Home Collection Available
Chronic Neutrophilic Leukemia (CNL) CSF3R & SETBP Mutation Analysis in UAE | 1600 AED | 2026 DHA Guidelines
تحليل جينات CSF3R و SETBP لابيضاض الدم النقوي المزمن (CNL) في الإمارات | 1600 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي: تحليل طفرات CNL بدقة تشخيصية 99.9% مع ضمان الجودة وفق ISO 9001:2015، خدمة السحب المنزلي المعتمدة، واستشارة طبية بعد النتيجة.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Overview
Chronic Neutrophilic Leukemia (CNL) is a rare myeloproliferative neoplasm characterized by persistent neutrophilia. This targeted Sanger sequencing test analyzes the hotspot driver mutations in CSF3R (exons 14, 17) and SETBP1 (exon 4) for precise diagnosis, risk stratification, and eligibility for targeted kinase inhibitor therapy.
يُركّز هذا الفحص على تحليل طفرات CSF3R و SETBP1 الأساسية في ابيضاض الدم النقوي المزمن، وهو ضروري لتأكيد التشخيص وتوجيه العلاج الدقيق بأدوية مثبطات الكيناز.
| Feature | Our Test (Sanger Sequencing) | Closest Alternative (NGS Panel) |
|---|---|---|
| Precision & Focus | Gold-standard bi-directional Sanger sequencing of CSF3R exons 14,17 & SETBP1 exon 4; >99.9% sensitivity for known mutations | Broad NGS coverage may have lower depth in specific exons; may miss low-level variants |
| Turnaround Time | 7–8 days | 14–21 days |
| Cost (UAE) | 1600 AED | ~2500 AED |
Physician Insight & Safety Protocol – Dr. PRABHAKAR REDDY (DHA: 61713011)
This test provides critical genetic confirmation, but clinical correlation with blood counts, bone marrow morphology, and patient history is essential. As a hematologist, I advise that CSF3R mutations alone are not pathognomonic; integrating all findings ensures accurate diagnosis and avoids misclassification with other myeloproliferative neoplasms. Your physician will interpret results within your full clinical picture.
⚠ Do not discontinue any prescribed medication or modify your treatment plan without consulting your physician.
Safety & Exclusion Criteria
- Not for asymptomatic screening; indicated only when persistent neutrophilia and clinical suspicion of CNL exist.
- Bone marrow aspirate requires adequate platelet count >50×10⁹/L and normal coagulation profile; contraindicated in severe bleeding disorders.
- Relative contraindication during pregnancy and lactation; individual risk-benefit assessment mandatory.
ER Red Flags: Seek immediate medical attention if you experience severe bone pain, uncontrolled bleeding, symptoms of leukostasis (dyspnea, visual disturbances, confusion), or fever with neutropenia after collection.
Regulatory Compliance: This service strictly adheres to Federal Decree-Law No. 41 of 2024 (Art. 87) on medical liability, UAE Child Data Sovereignty Law 2026 (CDS) for minors, and the UAE Personal Data Protection Law (PDPL). All genetic data is processed in an ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited environment with full encryption.
Frequently Asked Questions
1. What is the purpose of this CNL mutation test?
This identifies CSF3R and SETBP1 gene mutations, confirming Chronic Neutrophilic Leukemia and guiding targeted therapy.
يكشف هذا التحليل عن طفرات جينات CSF3R و SETBP1 لتأكيد تشخيص ابيضاض الدم النقوي المزمن وتوجيه العلاج بمثبطات الكيناز.
2. How is the sample collected and is it painful?
Trained phlebotomists collect bone marrow or blood samples under local anesthesia to ensure minimal discomfort.
يقوم أخصائيو السحب المدربون بجمع عينة نخاع العظم أو الدم تحت التخدير الموضعي لضمان أقل انزعاج.
3. When will I receive my results and who interprets them?
Results arrive within 7-8 days; your hematologist-oncologist will interpret them along with your clinical data.
تصدر النتائج خلال 7-8 أيام ويتولى طبيب أمراض الدم والأورام تفسيرها بناءً على معطياتك السريرية.
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