Test Price
700 AEDโ Home Collection Available
TEL/AML1 (ETV6-RUNX1) FISH Genetic Testing in UAE | 700 AED | DHA Licensed
Executive Summary & Core Metrics
Clinical Excellence Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited FISH Processing. Hospital Extraction Only โ Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. Complimentary Telephonic Post-Test Clinical Guidance. Insurance Direct Billing Verification via WhatsApp +971 54 548 8731.
This assay detects the ETV6-RUNX1 fusion gene, the most common favorable genetic translocation in pediatric B-cell acute lymphoblastic leukemia (ALL), enabling precise risk stratification and tailored therapy planning.
Test Overview & Methodology
The TEL/AML1 (ETV6-RUNX1) FISH test uses fluorescence in-situ hybridization to identify the cryptic t(12;21)(p13;q22) translocation that is not detectable by conventional karyotyping. This genetic marker is associated with a favorable prognosis in pediatric ALL and guides clinicians toward reduced-intensity chemotherapy protocols, improving quality of life while maintaining high cure rates. Results are integrated with flow cytometry, complete blood count, and clinical assessment for comprehensive diagnostic accuracy.
| Feature | Our TEL/AML1 FISH Test | Standard Cytogenetics |
|---|---|---|
| Methodology | Fluorescence In-Situ Hybridization (FISH) | Conventional Karyotyping |
| Turnaround Time | 3โ4 working days | 7โ14 days |
| Sensitivity | Detects cryptic t(12;21) at 99.9% sensitivity | Lower resolution, may miss small rearrangements |
| Sample | Bone Marrow / Peripheral Blood (Hospital Extraction) | Bone Marrow (preferred) |
Physician Insight & Safety Protocols
The TEL/AML1 FISH result provides a powerful favorable prognostic indicator in pediatric B-cell ALL, but it must always be interpreted alongside complete blood counts, immunophenotyping, and the full clinical picture. No single laboratory test replaces the comprehensive judgment of an experienced pediatric oncologist. Genomic data should guide, not dictate, therapy decisions.
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory & Precautions
โ ๏ธ Do not discontinue, alter, or initiate any prescribed medication or chemotherapy regimen solely based on this test result. Always consult your treating oncologist for integrated clinical decision-making.
Exclusion Criteria & Emergency Red Flags
- Severe thrombocytopenia (platelet count <20,000/ยตL) or uncorrected coagulopathy โ requires pre-procedure hematology clearance before bone marrow aspiration.
- Active bleeding disorder or ongoing anticoagulation therapy that cannot be safely interrupted under medical supervision.
- For pediatric patients, a legal guardian must provide written informed consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
๐จ Seek immediate emergency care if your child experiences unrelieved bone pain, fever exceeding 38.5ยฐC, unexplained bruising, or bleeding before the scheduled sample collection.
Patient FAQ & Clinical Guidance
1. Why is the TEL/AML1 FISH test ordered for my child with leukemia?
The assay specifically detects the ETV6-RUNX1 fusion gene, which is strongly correlated with a favorable prognosis in pediatric B-cell ALL. A positive result often supports the use of reduced-intensity chemotherapy, lowering the risk of long-term side effects while preserving excellent cure rates.
2. Can I request this test without a doctor referral?
A physician referral is required for oncological genetic testing. However, for pre-surgical clearance or second-opinion evaluations, a prescription from a licensed specialist suffices. Our team can assist with insurance verification and referral coordination via WhatsApp at +971 54 548 8731.
3. How do I interpret a positive TEL/AML1 result?
A positive finding indicates the presence of the ETV6-RUNX1 gene fusion, classified as a favorable genetic marker. Your oncologist will correlate this result with white blood cell count at diagnosis, immunophenotype, and other molecular markers to assign risk category and select the most appropriate treatment protocol.
4. Does this test replace a bone marrow biopsy?
No. The FISH test is performed on bone marrow or peripheral blood samples and provides complementary genetic information. A full diagnostic workup still requires morphological evaluation, flow cytometry, and clinical examination by a hematologist-oncologist.
UAE Regulatory & Data Privacy Adherence
All genetic testing and personal health data are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent, data encryption, and secure storage protocols are strictly enforced. The laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under the oversight of the Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | TEL/AML1 (ETV6-RUNX1) FISH Genetic Test |
| Price (AED) | 700 AED |
| Turnaround Time | 3โ4 working days |
| Sample Type / Matrix | Hospital Extraction Only โ Bone Marrow Aspirate / Peripheral Blood |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | C91.0 |
| LOINC Code | 33676-7 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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