Test Price
600 AEDโ Home Collection Available
t(1;19)(q23;p13) E2A Fusion Qualitative Test โ Molecular Diagnostics in Dubai
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited qPCR and Whole Genome Sequencing processing.
- Hospital Extraction Only โ Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Telephonic Post-Test Clinical Guidance with DHA-licensed genetics specialists for result interpretation.
- Direct Insurance Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This qualitative molecular assay detects the t(1;19)(q23;p13) E2A-PBX1 fusion transcript, a hallmark genetic event in B-cell acute lymphoblastic leukemia (B-ALL). The test uses gold-standard Real-Time PCR (qPCR) and is confirmed by Whole Genome Sequencing (WGS) to ensure maximum analytical accuracy for clinical decision-making.
| Feature | Our Test (Premium) | Conventional FISH |
|---|---|---|
| Methodology | Real-Time PCR + WGS (qPCR) | Fluorescence In-Situ Hybridization |
| Analytical Sensitivity | 1 leukemic cell in 10,000 (0.01%) | ~5% limit of detection |
| Turnaround Time | 3โ4 days | 5โ7 days |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh
Consultant Medical Genetics | DHA Registration ID: 9294403
โThe t(1;19)(q23;p13) E2A-PBX1 fusion is a critical prognostic and treatment-stratification marker in B-cell acute lymphoblastic leukemia. Detection of this fusion transcript guides risk-directed therapy and informs clinical decision-making. Results should always be correlated with morphological assessment and immunophenotyping before treatment adjustments.โ
Advisory Notice
โ ๏ธ Do not discontinue or modify prescribed medication without consulting your treating physician. This test is for diagnostic guidance and must be interpreted within the full clinical context by a qualified specialist.
Exclusion Criteria & Emergency Red Flags
- Severe anemia (Hb < 7 g/dL) or active bleeding โ prioritize medical stabilization before testing.
- Hemodynamic instability or acute sepsis โ defer elective bone marrow sampling.
- New neurological symptoms (seizure, altered consciousness) โ seek immediate emergency care.
Patient FAQ & Clinical Guidance
1. What does a positive t(1;19) result indicate for my treatment?
A positive result detects the E2A-PBX1 fusion gene transcript, which is a hallmark of B-cell acute lymphoblastic leukemia. This finding helps your oncologist stratify risk and select the most appropriate therapy protocol for your specific leukemia subtype.
2. How is the sample collected for this genetic test?
A bone marrow aspirate or peripheral blood sample is collected under sterile conditions within an accredited hospital setting. The specimen must be transported immediately in a temperature-controlled container to preserve RNA integrity for accurate molecular analysis.
3. Why is home collection not offered for this test?
Due to the invasive nature of bone marrow aspiration and the stringent cold-chain requirements for RNA preservation, this test is classified as a hospital-only procedure. All collections must be performed within an accredited medical facility by qualified clinical personnel.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
All clinical data and genetic information are handled in strict accordance with UAE federal law:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Federal Decree-Law No. 4 of 2016 on Medical Liability for clinical safety and patient consent.
DNA Labs UAE maintains full DHA licensure and adheres to the highest standards of genomic data confidentiality under UAE law.
Clinical & Logistical Metadata
| Test Name | t(1;19)(q23;p13) E2A Fusion Qualitative Test |
| Price (AED) | 600 AED |
| Turnaround Time | 3โ4 business days |
| Sample Type / Matrix | Bone marrow aspirate or peripheral blood (hospital extraction only) |
| Methodology Used | Real-Time PCR (qPCR) + Whole Genome Sequencing (WGS) |
| ICD-10-CM Code | C91.00 |
| LOINC Code | 48762-6 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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