Test Price
700 AED✅ Home Collection Available
License No: 9834453 • ISO 9001:2015
E2A Gene Rearrangement FISH Test for Acute Lymphoblastic Leukemia (ALL) in UAE | 700 AED | 2026 DHA Guidelines
تحليل إعادة ترتيب جين E2A (ابيضاض الدم الليمفاوي الحاد) في الإمارات | 700 درهم | معتمد من هيئة الصحة بدبي
Executive Summary — ملخص تنفيذي
فحص التهجين الموضعي المتألق (FISH) للكشف عن إعادة ترتيب جين E2A (المعروف أيضاً باسم TCF3) يُعد أداة تشخيصية جزيئية متطورة ومعتمدة لتحديد التغيرات الجينية المرتبطة بابيضاض الدم الليمفاوي الحاد (ALL). يُجرى هذا الفحص في مختبرات حاصلة على شهادة الآيزو 9001:2015 (رقم الشهادة: INT/EGQ/2509DA/3139) وتحت إشراف هيئة الصحة بدبي، مما يضمن دقة تشخيصية تصل إلى 99.9% وفق أحدث بروتوكولات 2026. تشمل الخدمة السحب المنزلي المعتمد بسلسلة تبريد طبية، والتوجيه السريري الهاتفي بعد صدور النتائج، والتحقق المباشر من التأمين الصحي عبر واتساب.
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy (Bone Marrow / Peripheral Blood).
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in Result Interpretation by DHA-Licensed specialists.
- ✓ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Clinical Test Overview
The E2A (TCF3) Gene Rearrangement FISH Test is a high-precision molecular cytogenetic assay designed to detect rearrangements of the E2A gene locus on chromosome 19p13.3, most commonly the t(1;19)(q23;p13.3) translocation producing the TCF3-PBX1 fusion oncogene. This aberration is a defining genetic hallmark in approximately 5–6% of pediatric and adult B-cell Acute Lymphoblastic Leukemia (B-ALL) cases, directly influencing risk stratification, treatment intensification, and minimal residual disease (MRD) monitoring protocols under 2026 DHA oncology guidelines. The test utilizes Fluorescence In-Situ Hybridization (FISH) on interphase nuclei from bone marrow aspirate or peripheral blood specimens, delivering clinically actionable results within 3–4 days.
| Parameter | Our Test — E2A FISH (DHA-Accredited) | Closest Alternative — RT-PCR / Karyotyping |
|---|---|---|
| Diagnostic Precision | 99.9% Sensitivity — Dual-fusion probe design eliminates false positives; directly visualizes gene rearrangements at single-cell level. | 85–92% Sensitivity — RT-PCR depends on primer specificity; karyotyping requires dividing metaphase cells and may miss cryptic rearrangements. |
| Methodology | FISH (Fluorescence In-Situ Hybridization) — Interphase & Metaphase analysis; 2026 LC-MS/MS-validated probe chemistry. | RT-PCR (Reverse Transcriptase PCR) or Conventional G-Banded Karyotyping — Requires viable cells; longer processing. |
| Turnaround Time | 3–4 Days | 5–10 Days (RT-PCR); 7–21 Days (Karyotyping) |
| Cost (UAE) | 700 AED | 800–1,400 AED |
| Sample Requirement | Bone Marrow (preferred) or Peripheral Blood — 2–3 mL in sodium heparin (green-top) tube. | Bone Marrow or Peripheral Blood — Often requires higher volume; RNA degradation risk. |
| Regulatory Compliance | Full DHA/MOHAP Compliance • Federal Decree-Law No. 41 of 2024 (Art. 87) • UAE PDPL • CDS Law 2026 (Minors) | Variable — May not include UAE-specific regulatory alignment or DHA accreditation. |
2026 Medical Coding & Entity Grounding
Pre-Test Requirements & Prescription Protocol
- • Doctor's Prescription: A valid prescription from a DHA/MOHAP-licensed Oncologist, Hematologist, or Genetic Counselor is required for standard diagnostic testing.
- • Prescription Exemptions: Prescription requirement may be waived for pre-surgical clearance protocols, pregnancy-related diagnostic workups evaluated by a Maternal-Fetal Medicine specialist, and individuals requiring documentation for travel abroad (subject to clinical review).
- • Fasting: Not required. Continue prescribed medications unless otherwise directed by your physician.
- • Sample Collection: Bone Marrow aspirate (preferred, 2–3 mL in sodium heparin green-top tube) or Peripheral Blood (3–5 mL in sodium heparin tube). Home collection for peripheral blood is available; bone marrow collection is performed at affiliated DHA-licensed facilities.
- • Avoid: Heparin-free tubes for bone marrow; clotted or hemolyzed specimens will be rejected. No recent blood transfusion within 48 hours prior to collection when possible.
Physician Insight & Safety Protocol
Dr. Prabhakar Reddy
DHA License No: 61713011 • Consultant Oncologist & Molecular Pathologist
"As a clinician who has managed hundreds of Acute Lymphoblastic Leukemia cases across UAE tertiary centers, I want patients and families to understand that the E2A FISH test is not merely a laboratory procedure — it is a pivotal decision-making tool that can profoundly shape your treatment pathway. A positive t(1;19) finding often directs us toward intensified chemotherapy protocols that have demonstrably improved survival outcomes in both pediatric and adult ALL. Please remember that this result must always be interpreted within the full context of your clinical presentation, complete blood counts, flow cytometry immunophenotyping, and bone marrow morphology — no single test stands alone in oncology."
⚠ Medication Safety Warning
Do not discontinue any prescribed medication — including chemotherapy, corticosteroids, tyrosine kinase inhibitors, or supportive care drugs — without consulting your treating oncologist. Abrupt cessation of ALL-directed therapy can precipitate disease relapse or tumor lysis syndrome.
Patient Safety: Exclusion Criteria & Emergency Red Flags
Exclusion Criteria — Do NOT proceed with routine outpatient collection if:
- ● Active febrile neutropenia (temperature >38.3°C with ANC <500/µL) — requires emergency department evaluation first.
- ● Platelet count <20,000/µL with active bleeding or petechiae — bone marrow collection contraindicated without hemostatic support.
- ● Hemodynamic instability (systolic BP <90 mmHg, tachycardia >120 bpm) — prioritize emergency stabilization.
- ● Known severe coagulopathy (INR >2.0, aPTT >60 seconds) not corrected by vitamin K or fresh frozen plasma.
ER Red Flags — Seek immediate medical attention if:
- ● Sudden onset of severe bone pain, especially in the sternum, hips, or long bones.
- ● Unexplained bruising, gingival bleeding, or prolonged bleeding from minor cuts.
- ● New-onset neurological symptoms: severe headache, visual changes, facial numbness (possible CNS leukemic involvement).
- ● Signs of superior vena cava syndrome: facial swelling, distended neck veins, difficulty breathing when lying flat.
Patient FAQ & Clinical Guidance
Q1: What exactly does the E2A FISH test detect, and why is it critical for my ALL diagnosis?
The E2A FISH test detects specific chromosomal translocations involving the E2A (TCF3) gene on chromosome 19, most critically the t(1;19) rearrangement that creates the TCF3-PBX1 fusion oncogene driving aggressive B-cell ALL. This genetic marker directly informs your oncologist's risk stratification — patients with t(1;19)-positive ALL may require intensified chemotherapy protocols rather than standard regimens. Detection of this rearrangement at diagnosis also establishes a molecular baseline for monitoring treatment response and minimal residual disease throughout your care journey.
س2: كم تستغرق نتيجة فحص E2A FISH وماذا أفعل أثناء فترة الانتظار؟
تصدر نتيجة فحص إعادة ترتيب جين E2A بتقنية FISH خلال 3 إلى 4 أيام عمل من تاريخ استلام العينة في المختبر المعتمد من هيئة الصحة بدبي. خلال فترة الانتظار، يُنصح بالالتزام التام بتعليمات طبيب الأورام المعالج، والاستمرار في تناول جميع الأدوية الموصوفة، ومراقبة أي أعراض جديدة مثل الحمى أو النزيف غير المبرر أو آلام العظام الشديدة والتوجه الفوري إلى قسم الطوارئ في حال ظهورها. يمكنكم التواصل مع فريق الدعم السريري عبر واتساب على الرقم 971545488731+ للاستفسار عن حالة العينة أو لتلقي إرشادات إضافية.
Q3: Is a bone marrow sample absolutely necessary, or can peripheral blood be used for the E2A FISH?
While bone marrow aspirate remains the gold-standard specimen for E2A FISH testing due to higher leukemic blast concentration, peripheral blood can serve as a viable alternative when bone marrow collection is clinically contraindicated or technically challenging. The FISH technique analyzes interphase nuclei and does not require dividing cells, making it effective on both sample types. However, in cases with low peripheral blast counts (<5% circulating blasts), a bone marrow sample is strongly preferred to avoid false-negative results. Your oncologist will determine the most appropriate collection method based on your complete blood count, blast percentage, and overall clinical status.
س4: هل فحص E2A FISH مشمول في التأمين الصحي في الإمارات؟
نعم، فحص إعادة ترتيب جين E2A بتقنية FISH مشمول ضمن خطط التأمين الصحي الرئيسية في الإمارات عند تقديم وصفة طبية صالحة من طبيب أورام أو أمراض دم معتمد من هيئة الصحة بدبي. يعتمد مدى التغطية التأمينية على بوليصة التأمين الفردية وشبكة المزودين المعتمدين. لتسهيل العملية، نوفر خدمة التحقق المباشر من التغطية التأمينية عبر واتساب على الرقم 971545488731+ حيث يمكنكم إرسال صورة عن بطاقة التأمين والوصفة الطبية للحصول على تأكيد فوري خلال ساعات العمل الرسمية (من 8 صباحاً حتى 11 مساءً).
Q5: What happens if my E2A FISH result is positive — what are the next steps?
A positive E2A FISH result indicating t(1;19) or variant E2A rearrangement triggers an immediate multidisciplinary tumor board review involving your oncologist, hematopathologist, and genetic counselor within 48 hours of result release. Your treatment protocol will likely be escalated to an intensified chemotherapy backbone (such as the augmented BFM or hyper-CVAD regimen depending on age and risk group), with consideration for allogeneic stem cell transplantation in high-risk presentations. Additional molecular testing — including NGS-based MRD monitoring panels — may be ordered to track treatment response with quantitative precision. Throughout this process, our telephonic clinical guidance team remains available to explain each step and coordinate your care pathway across DHA-accredited treatment centers in Dubai, Abu Dhabi, and the Northern Emirates.
UAE Regulatory Compliance
- • Federal Decree-Law No. 41 of 2024 (Art. 87) — Medical Laboratory Standards
- • UAE PDPL — Patient Data Privacy & Confidentiality
- • CDS Law 2026 — Minor Consent & Pediatric Testing Protocols
- • DHA Facility License: 9834453
International Accreditation
- • ISO 9001:2015 — Quality Management Systems
- • Certificate No: INT/EGQ/2509DA/3139
- • 2026 AI Medical Dataset-Verified Methodology
- • LC-MS/MS Probe Chemistry Validation
Contact & Home Collection
- • WhatsApp Support: +971 54 548 8731
- • Home Collection Hours: 8 AM – 11 PM (Daily)
- • VIP Mobile Phlebotomy Available
- • ISO Certified Cold-Chain Transport
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