Test Price
2,800 AED✅ Home Collection Available
FOXRED1 Gene – Leigh Syndrome: Next-Generation Sequencing (NGS) Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited next-generation sequencing for comprehensive FOXRED1 variant detection.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test clinical guidance with a DHA-licensed consultant medical geneticist for result interpretation and family risk assessment.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This test employs next-generation sequencing (NGS) to analyze the FOXRED1 gene, which encodes a mitochondrial complex I assembly factor. Pathogenic variants in FOXRED1 are a well-established cause of autosomal recessive Leigh syndrome, a progressive neurometabolic disorder typically presenting in infancy or early childhood. The assay provides full coverage of all coding exons and exon-intron boundaries, enabling high-confidence detection of single-nucleotide variants and small insertions or deletions.
| Feature | Our Test (NGS) | Sanger Sequencing (Alternative) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity; full gene coverage including intronic boundaries | ~98% sensitivity; limited to targeted exons |
| Methodology | Next-Generation Sequencing with LC-MS/MS validation | Bidirectional Sanger sequencing |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Pre-Test Genetic Counselling | Mandatory, integrated session | Often optional |
Physician Insight & Safety Protocols
"Genetic testing for FOXRED1-related Leigh syndrome requires careful variant interpretation and correlation with clinical presentation. A negative result does not exclude other mitochondrial etiologies. Comprehensive post-test counseling is essential for families to understand recurrence risks and management options. All results must be considered within the full clinical context."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics
DHA Registration ID: 9294403
Advisory & Medication Guidance
Consult Your Physician Before Making Changes
Do not discontinue, adjust, or initiate any prescribed medication without explicit guidance from your treating physician. Genetic test results may inform but do not replace clinical management decisions.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Uncontrolled bleeding diathesis, inability to provide informed consent (minors require parental or guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability), or failure to complete mandatory pre-test genetic counselling.
- Data Protection: All genetic data handled in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Seek Emergency Care if: Sudden worsening of neurological symptoms, seizures, respiratory distress, or loss of consciousness occur at any point during the diagnostic process.
Patient FAQ & Clinical Guidance
1. What does the FOXRED1 gene test detect?
This test sequences the entire FOXRED1 gene to identify pathogenic mutations causing autosomal recessive Leigh syndrome. The analysis covers all coding exons and adjacent splice sites, providing a definitive molecular diagnosis when clinical signs and biochemical markers are suggestive of the condition.
2. How long will it take to receive my results?
Results are typically ready within 3 to 4 weeks from sample receipt, enabling timely clinical decision-making. Turnaround time begins upon arrival of a properly collected blood sample or extracted DNA at the laboratory and may vary slightly during peak testing periods.
3. Is genetic counseling mandatory before and after the test?
Yes, UAE law requires mandatory genetic counselling to ensure informed consent and psychosocial support. Our DHA-licensed consultant medical geneticist will draw a pedigree chart, explain possible outcomes, and guide you through result interpretation in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
4. What sample type is required for this genetic test?
A standard peripheral whole blood sample (3–5 mL in an EDTA tube) is required. Extracted DNA of sufficient quality and quantity may also be accepted. The sample can be collected via our VIP mobile phlebotomy service at your home or at a designated collection center.
5. Will insurance cover the cost of the test?
Coverage varies by insurance provider and policy. Our team can verify your direct billing eligibility via WhatsApp. Please send a photo of your insurance card to +971 54 548 8731 for a preliminary coverage assessment.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates under DHA Facility License No. 1143 and adheres to the UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient data handling. All genetic information is processed, stored, and transmitted in compliance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring end-to-end encryption and strict access controls. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability, guaranteeing that every test is performed with full informed consent and medical oversight.
Clinical & Logistical Metadata
| Test Name | FOXRED1 Gene – Leigh Syndrome NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | E88.81 |
| LOINC Code | 81262-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians