Test Price
2,800 AED✅ Home Collection Available
LDLR Gene Hypercholesterolemia due to LDL‑Receptor Disorder (Autosomal Dominant) Genetic Test in UAE
Executive Summary & Core Metrics
The LDLR Gene Hypercholesterolemia Genetic Test definitively identifies pathogenic variants in the LDLR gene causing autosomal dominant familial hypercholesterolemia — the most prevalent genetic lipid disorder leading to premature coronary artery disease. This analysis enables cascade screening of at‑risk relatives and personalised statin or PCSK9 inhibitor therapy. With 99.9% diagnostic sensitivity and ISO‑accredited processing, the test provides definitive molecular diagnosis where standard lipid profiling cannot distinguish genetic from acquired hyperlipidemia.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
Next‑Generation Sequencing (NGS) with full LDLR gene coverage is employed to detect single‑nucleotide variants, small insertions or deletions, and splice‑site alterations associated with autosomal dominant familial hypercholesterolemia. The assay achieves 99.9% analytical sensitivity and specificity, and results are interpreted in accordance with ACMG/AMP guidelines. The table below contrasts this molecular approach against a standard lipid profile.
| Parameter | Our NGS LDLR Test | Closest Alternative: Standard Lipid Profile |
|---|---|---|
| Diagnostic Precision | Identifies exact causative mutation; 99.9% analytical sensitivity | Measures LDL‑C level only; cannot distinguish genetic vs. acquired hyperlipidemia |
| Methodology | Next‑Generation Sequencing (NGS) with full gene coverage | Enzymatic colorimetric assay |
| Turnaround Time | 3 – 4 Weeks | Same day |
| Clinical Utility | Pre‑symptomatic diagnosis, family cascade screening, personalised drug selection | Disease monitoring only; no predictive genetic insight |
| Price | 2800 AED | ~200 AED (insured) |
Physician Insight & Safety Protocols
“Identifying a pathogenic LDLR variant provides the cornerstone for precision management of familial hypercholesterolemia. This test offers definitive molecular evidence that guides both individual treatment and cascade screening for blood relatives. My team and I are committed to ensuring you fully understand the results and their implications for your cardiovascular health.”
– Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Safety Exclusion Criteria & Emergency Red Flags
- Test not recommended for individuals under 18 years without signed parental consent and formal genetic counselling in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability and DHA regulatory guidelines.
- Do NOT delay emergency care for new‑onset acute chest pain, dyspnoea, syncope, or stroke‑like symptoms; proceed to the nearest emergency department immediately.
- This test is not a substitute for ongoing lipid‑lowering medication; do not discontinue or adjust therapy without consulting your doctor.
- If you are pregnant or have a concurrent severe infection, consult your physician before scheduling sample collection.
Medication Advisory
Do not discontinue prescribed statins, anti‑platelet agents, or any medication without consulting your doctor. Abrupt cessation can provoke acute cardiovascular events. Continue all therapies as directed and discuss any concerns during your post‑test clinical consultation.
Patient FAQ & Clinical Guidance
1. What is the LDLR gene hypercholesterolemia test, and why is it important?
This test sequences your LDLR gene to identify mutations causing familial hypercholesterolemia, enabling early intervention to prevent heart disease. It delivers a definitive genetic diagnosis that a standard cholesterol measurement cannot provide, allowing personalised treatment and family‑wide cascade screening.
2. How is the sample collected, and what should I expect?
A licensed phlebotomist performs a standard peripheral blood draw at your home or office. The procedure is quick, minimally uncomfortable, and follows strict cold‑chain protocols to preserve specimen integrity. Results are typically available within three to four weeks.
3. What does a positive result mean for my family?
A positive result confirms a pathogenic LDLR variant inherited in an autosomal dominant pattern. Each first‑degree relative has a 50% chance of carrying the same mutation. Cascade testing is strongly recommended so that at‑risk family members can benefit from early lipid‑lowering therapy and cardiovascular surveillance.
UAE Regulatory & Data Privacy Adherence
Your data is protected under UAE federal law. This laboratory operates in full compliance with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the collection, processing, and storage of personal information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – regulating digital health data and telemedicine practices.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – establishing standards for clinical safety, patient consent, and professional accountability.
All genetic results are encrypted, access‑controlled, and never shared with third parties without explicit written consent. You retain the right to access, correct, or request deletion of your data at any time.
Clinical & Logistical Metadata
| Test Name | LDLR Gene Hypercholesterolemia due to LDL‑Receptor Disorder (Autosomal Dominant) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Next‑Generation Sequencing (NGS) with full LDLR gene coverage |
| ICD‑10‑CM Code | E78.01 (Familial hypercholesterolemia) |
| LOINC Code | 46871‑8 (LDLR gene mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
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