Test Price
2,800 AEDโ Home Collection Available
TMPRSS6 Gene Analysis for Iron-Refractory Iron Deficiency Anemia (IRIDA) via NGS in UAE | 2800 AED | DHA Guidelines
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing. Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM). Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation with genetic counseling included. Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TMPRSS6 Gene Analysis for Iron-Refractory Iron Deficiency Anemia (IRIDA) employs high-depth next-generation sequencing (NGS) to identify pathogenic variants in the TMPRSS6 gene, which encodes matriptase-2, a key regulator of hepcidin expression. This definitive molecular test eliminates the need for invasive bone marrow biopsies and repeated ineffective iron trials, providing a single, actionable genetic answer. The complete coding region and splice sites are sequenced with >99.9% sensitivity, enabling precise diagnosis, personalized treatment adjustments, and cascade screening for at-risk family members in the UAE population.
Diagnostic Precision Compared to Standard Approaches
| Feature | Our Test (TMPRSS6 NGS) | Closest Alternative (Serum Ferritin & Iron Studies) |
|---|---|---|
| Diagnostic Precision | >99.9% sensitivity for TMPRSS6 variants | Indirect; cannot differentiate IRIDA from classic iron deficiency |
| Methodology | High-depth NGS with full gene coverage | Biochemical assays; non-genetic |
| Turnaround Time | 3 to 4 Weeks | 1โ3 Days |
| Clinical Utility | Confirms IRIDA, guides cessation of futile iron therapy, enables family screening | Often leads to misdiagnosis and prolonged iron overload risk |
Physician Insight & Safety Protocols
โThe TMPRSS6 NGS panel provides definitive molecular confirmation of IRIDA, enabling clinicians to discontinue ineffective oral iron and adopt targeted therapies such as intravenous ferric carboxymaltose or novel hepcidin antagonists. While the result is robust, clinical correlation with a hematologist remains essential. Never self-adjust prescribed regimens without a complete medical review.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Continuity
Do not discontinue any prescribed iron supplementation, erythropoiesis-stimulating agents, or other hematologic medications unless explicitly instructed by your treating physician. Abrupt cessation may lead to clinical deterioration. This genetic test is a diagnostic adjunct, not a substitute for ongoing medical supervision.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Children under 18 years require explicit pediatrician authorization and guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability; acute febrile illness or active infection; known bleeding diathesis not controlled.
- Emergency Red Flags After Blood Collection: Sudden severe pallor, difficulty breathing, chest pain, or syncope require immediate medical attention at the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the TMPRSS6 genetic test for iron-refractory anemia?
This next-generation sequencing test identifies mutations in the TMPRSS6 gene that cause iron-refractory iron deficiency anemia (IRIDA), enabling precise diagnosis and personalized treatment planning. It directly detects the genetic defect impairing oral iron absorption, distinguishing IRIDA from common iron deficiency and avoiding unnecessary iron infusions. Results assist hematologists in targeting alternative therapies such as intravenous iron or novel agents. Genetic counseling is included for family planning and cascade screening.
2. How is the sample collected and what is the home collection process?
A certified phlebotomist visits your home between 8 AM and 11 PM to collect 2โ3 mL of whole blood in a special DNA stabilization tube, ensuring cold-chain transport. Alternatively, a dried blood spot on an FTA card may be provided. The sample is sent to our ISO-certified molecular laboratory under strict chain-of-custody, and you receive a notification when processing begins. The VIP mobile service is available across all seven emirates.
3. How do I interpret my results and what are the next steps?
Your report details any pathogenic variant, its zygosity, and clinical significance, accompanied by a post-test telephonic consultation with a genetic counselor. A positive finding confirms IRIDA, guiding cessation of oral iron and initiation of targeted management. A negative result may still warrant further hematological workup. Genetic counseling is included for family planning and cascade screening of relatives.
UAE Regulatory & Data Privacy Adherence
Your genetic data is processed under strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing adheres to the safety and consent standards of Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE is DHA-licensed (Facility No. 1143) and ISO 15189 accredited, ensuring the highest levels of confidentiality, integrity, and medical accountability throughout the diagnostic pathway.
Clinical & Logistical Metadata
| Test Name | TMPRSS6 Gene Analysis for IRIDA via NGS |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (2โ3 mL) or Dried Blood Spot |
| Methodology Used | High-Depth Next-Generation Sequencing (NGS) with Full Gene Coverage |
| ICD-10-CM Code | D50.8 |
| LOINC Code | 51924-9 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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