Test Price
2,800 AED✅ Home Collection Available
DPY19L2 Gene (SPGF9) Genetic Test for Male Infertility in Dubai
Executive Summary & Core Metrics
Accredited Genetic Diagnostics for Globozoospermia
The DPY19L2 (SPGF9) genetic test utilizes Next-Generation Sequencing to detect pathogenic variants causing globozoospermia, a severe male infertility condition. Priced at 2,800 AED, this test provides 99.9% diagnostic sensitivity for complete gene sequencing and copy number variation (CNV) analysis. Samples are collected via VIP Mobile Phlebotomy with cold-chain logistics (8 AM – 11 PM) or at our Dubai Healthcare City facility. Results are delivered within 3 to 4 weeks, accompanied by telephonic post-test genetic counselling by a DHA-licensed specialist.
Test Overview & Methodology
Globozoospermia (SPGF9) is an autosomal recessive disorder caused predominantly by biallelic deletions or point mutations in the DPY19L2 gene. This test provides comprehensive analysis of the DPY19L2 gene, identifying both single nucleotide variants (SNVs) and large deletions or duplications (CNVs) that standard methods may miss. The methodology employs targeted enrichment, next-generation sequencing on an accredited Illumina platform, and rigorous bioinformatics annotation against GRCh38. A positive result confirms the genetic basis of the morphological sperm defect, directly guiding clinical management and fertility planning.
| Feature | Our Test (DPY19L2 NGS) | Closest Alternative |
|---|---|---|
| Precision | Full gene sequencing with CNV detection – 99.9% sensitivity | Targeted mutation panel – limited to known hotspots |
| Methodology | Next-Generation Sequencing (NGS) with bioinformatics annotation | Sanger sequencing – lower throughput, no CNV analysis |
| Turnaround Time | 3 to 4 weeks | 6 to 8 weeks |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specialist, I confirm that a molecular diagnosis of DPY19L2-related globozoospermia provides crucial prognostic information for couples pursuing ICSI. It is essential to correlate the genetic result with a thorough semen analysis and clinical history. Pre-test and post-test genetic counselling by a qualified professional is mandatory to discuss autosomal recessive inheritance patterns and recurrence risks for future pregnancies."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Important Clinical Advisory
This genetic test result must not be used as a standalone diagnostic tool. Do not modify or discontinue any ongoing fertility treatments without consulting your referring physician. The laboratory strongly recommends a formal genetics consultation for result disclosure and management planning.
Patient Suitability & Exclusion Criteria
This test is indicated for adult male patients with clinical suspicion of globozoospermia (round-headed spermatozoa lacking acrosomes) identified on semen analysis, or for individuals with a known family history of DPY19L2 mutations. It is not indicated for patients with obstructive azoospermia, hypogonadotropic hypogonadism, or unexplained infertility without prior semen analysis showing specific morphological defects.
Patient FAQ & Clinical Guidance
1. What is globozoospermia and how does the DPY19L2 genetic test help in diagnosis?
Globozoospermia is a rare genetic disorder where sperm cells have round heads and lack an acrosome, making natural fertilization difficult. The DPY19L2 gene test identifies the underlying genetic mutation, confirming the diagnosis and enabling couples to pursue targeted fertility treatments such as Intracytoplasmic Sperm Injection (ICSI), which can bypass the morphological defect.
2. How is the sample collected for the DPY19L2 genetic test in the UAE?
The test requires a standard peripheral whole blood sample or a buccal swab. Our certified phlebotomists provide a VIP Mobile Phlebotomy service across Dubai and the Northern Emirates, operating daily from 8 AM to 11 PM. The sample is transported via temperature-controlled cold-chain logistics to our ISO 9001:2015 accredited laboratory in Dubai Healthcare City.
3. What is the turnaround time for the DPY19L2 genetic test results?
The turnaround time for complete sequencing, CNV analysis, and clinical reporting is 3 to 4 weeks from the date of sample receipt. Results are reviewed and signed off by our Consultant Medical Genetics specialist before being securely delivered to the patient and referring physician.
4. Is genetic counselling provided with the DPY19L2 genetic test?
Yes, our DHA-licensed genetic counsellors provide telephonic pre-test and post-test counselling to ensure patients fully understand the implications of their results. This includes guidance on inheritance patterns, reproductive options, and familial recurrence risks.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License No: 1143. We strictly adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes with explicit patient consent. Clinical safety and liability protocols conform to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | DPY19L2 Gene (SPGF9) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) + CNV Analysis |
| ICD-10-CM Code | N46.9, Z31.41, Z13.79 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License: 1143 |
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