Test Price
850 AEDโ Home Collection Available
Succinylacetone Urine Test in UAE | 850 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited LC-MS/MS Processing.
- Premium Logistics: Temperature-Controlled Cold-Chain Home Collection with sterile urine container provided; immediate refrigeration required.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by a licensed General Practitioner.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The Succinylacetone Urine Test quantifies succinylacetone, a toxic metabolite that accumulates due to deficiency of fumarylacetoacetate hydrolase (FAH) enzyme. This test is critical for diagnosing Hereditary Tyrosinemia Type I (HT-1), an autosomal recessive disorder that can lead to liver failure, renal tubular dysfunction, and neurological crises if untreated. Detection via Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) provides the highest analytical specificity and sensitivity available, ensuring reliable quantification at trace concentrations.
| Feature | Our Test (LC-MS/MS) | Standard GC/MS |
|---|---|---|
| Methodology | Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) โ Gold Standard | Gas Chromatography/Mass Spectrometry (GC/MS) |
| Analytical Sensitivity | 99.9% โ Ultra-precise quantification down to sub-micromolar levels | ~95% โ Susceptible to matrix interference and co-elution artifacts |
| Turnaround Time | 3โ4 working days (Mon/Thu by 9 am; Report Thu/Mon) | 5โ7 working days |
| ISO Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Variable per laboratory |
Physician Insight & Safety Protocols
โElevated succinylacetone in urine is a hallmark biomarker for hereditary tyrosinemia type I and demands immediate confirmatory evaluation. While this test serves as a powerful screening tool, a definitive diagnosis requires integrated assessment by a metabolic specialist. Early detection through this assay directly improves prognostic outcomes in affected infants. Patients and caregivers should note that sample collection must be performed under stable clinical conditions to avoid confounding results.โ
โ Dr. Ajay Singh, General Practitioner | DHA Registration ID: 36234132
Advisory & Clinical Precautions
Medication Continuation: Never discontinue prescribed nitisinone (NTBC) or dietary management without consulting a metabolic physician. Interruption of therapy can precipitate metabolic decompensation.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria: Patients with acute febrile illness, severe dehydration, or active urinary tract infection may exhibit altered metabolite levels and should not provide samples during an acute crisis without documented clinical context.
ER Red Flags: Sudden vomiting, lethargy, seizures, jaundice, hepatomegaly, or a distinctive cabbage-like odor in infants require immediate emergency evaluation. These signs indicate possible metabolic decompensation requiring urgent medical intervention.
Patient FAQ & Clinical Guidance
1. What is the succinylacetone urine test used for?
Snippet Answer: This test screens for hereditary tyrosinemia type I, a severe autosomal recessive metabolic disorder. Elevated succinylacetone indicates deficient FAH enzyme activity, prompting confirmatory enzyme assay or genetic sequencing and immediate dietary intervention to prevent liver and kidney failure.
2. How should I prepare my child for sample collection?
Snippet Answer: Collect 10 mL of random urine in a sterile screw-capped container without preservatives and refrigerate immediately at 2โ8ยฐC. No dietary restrictions are required prior to collection. Provide a brief clinical history including presenting symptoms and family history of metabolic disorders.
3. What does an elevated succinylacetone result mean?
Snippet Answer: An elevated level strongly indicates hereditary tyrosinemia type I, necessitating urgent specialist consultation for confirmatory FAH enzyme assay or gene sequencing. Early treatment with nitisinone (NTBC) combined with a tyrosine/phenylalanine-restricted diet prevents life-threatening hepatic, renal, and neurological complications.
UAE Regulatory & Data Privacy Adherence
All patient data and clinical results are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Diagnostic testing and patient consent follow the provisions of Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to ISO 9001:2015 quality management standards for all laboratory processes.
Clinical & Logistical Metadata
| Test Name | Succinylacetone Urine Test |
| Price (AED) | 850 AED |
| Turnaround Time | 3โ4 working days (Mon/Thu by 9 am; Report Thu/Mon) |
| Sample Type / Matrix | Random urine (10 mL) โ sterile screw-capped container, no preservatives, refrigerate immediately at 2โ8ยฐC |
| Methodology Used | Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
| ICD-10-CM Code | E70.21 |
| LOINC Code | 32624-8 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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