Test Price
2,800 AEDโ Home Collection Available
NCF4 Gene Chronic Granulomatous Disease Type 3 (Autosomal Recessive, Cytochrome b-Positive) Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189:2023 accredited NGS processing, detecting pathogenic variants in NCF4 with full gene coverage.
Premium Logistics: Complimentary VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM. Sample types include whole blood, extracted DNA, or one-drop blood on FTA card.
Clinical Guidance: Telephonic post-test genetic counselling and result interpretation included.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test identifies nucleotide-level variants in the NCF4 gene responsible for autosomal recessive chronic granulomatous disease type 3 (cytochrome b-positive). Early genetic confirmation allows precise clinical management, carrier screening, and informed family planning.
| Feature | Our NCF4 NGS Test (ISO 15189:2023) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Technology | Massively parallel NGS (full gene + flanking regions) | Single-gene Sanger (limited to known hotspots) |
| Turnaround Time | 3 โ 4 weeks | 6 โ 8 weeks |
| Variant Detection | SNVs, indels, copy number variants (CNV) | Only preselected exons |
| Clinical Utility | Diagnostic + carrier screening + pharmacogenomic insights | Limited to confirmatory diagnosis |
Physician Insight & Safety Protocols
โAs a Consultant Medical Geneticist, I emphasize that a molecular diagnosis of NCF4-related CGD type 3 is a cornerstone for prophylactic antimicrobial and immunomodulatory strategies. Nevertheless, genetic findings must be correlated with clinical phenotype, neutrophil function assays, and family history โ no single test replaces comprehensive evaluation.โ
โ Lina Osama Zaki Quteineh, DHA Registration ID: 9294403
Pre-Test Genetic Counselling & Pedigree
A mandatory pre-test genetic counselling session is arranged to construct a detailed threeโgeneration pedigree of family members affected by chronic granulomatous disease. Please provide the complete clinical history of the proband and any suspected carriers. This session is vital for accurate risk estimation and sample triage.
Accepted Sample Types: Whole blood (EDTA), extracted DNA, or one drop of blood on an FTA card. Instructions for home collection will be provided by our phlebotomy team.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent allogeneic hematopoietic stem cell transplant (discuss with genetic counsellor; donor DNA may confound results).
- Exclusion: Whole blood transfusion within the last 4 weeks (may mask germline variants).
- Red Flag: Sudden high fever (>38.5ยฐC), painful lymphadenopathy, or new purulent infections โ seek emergency care immediately; CGD patients are at risk for overwhelming sepsis.
- Red Flag: Unexplained bruising, petechiae, or splenic abscess โ prompt hospital evaluation required.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the NCF4 NGS test, and how does it influence treatment?
Direct answer: The test identifies disease-causing mutations in the NCF4 gene, enabling early initiation of antimicrobial prophylaxis, interferon-gamma therapy, and eligibility assessment for curative hematopoietic stem cell transplantation.
2. How long will it take to receive my NCF4 genetic test results?
Direct answer: Total turnaround time is 3 to 4 weeks from sample accessioning, including library preparation, deep sequencing, bioinformatics analysis, and clinical report interpretation by a board-certified geneticist.
3. Is this test approved by UAE health authorities and international standards?
Direct answer: The laboratory holds DHA facility license 1143 and operates under ISO 15189:2023 standards, fully compliant with UAE Personal Data Protection Law (PDPL), Federal Law No. 2 of 2019 on ICT in Health, and Federal Decree-Law No. 4 of 2016 on Medical Liability.
UAE Regulatory & Data Privacy Adherence
UAE Legal Compliance: This service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted, stored within the UAE, and destroyed after the legally mandated period unless otherwise authorized.
ISO 15189:2023 Accredited. DHA Facility License: 1143. Contact for verification or complaints: +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | NCF4 Gene Chronic Granulomatous Disease Type 3 (Autosomal Recessive, Cytochrome b-Positive) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 โ 4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card sample |
| Methodology Used | Next-Generation Sequencing (NGS), full gene + flanking regions |
| ICD-10-CM Code | D71 (Chronic granulomatous disease) |
| LOINC Code | 81695-9 (NCF4 gene mutation analysis in blood or tissue by NGS) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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