Test Price
2,800 AED✅ Home Collection Available
CD3E Gene (Immunodeficiency Type 18) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance by a DHA-licensed genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Primary Indication: Diagnosis of Immunodeficiency Type 18 (CD3ε deficiency) – autosomal recessive severe combined immunodeficiency.
- DHA Facility License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Test Overview & Methodology
This definitive genetic test analyses the entire coding region of the CD3E gene using next‑generation sequencing (NGS) to diagnose or rule out Immunodeficiency Type 18 (CD3ε deficiency), an autosomal recessive severe combined immunodeficiency presenting with recurrent infections, failure to thrive, and dermatological complications. The targeted approach delivers 100% coverage of CD3E exons ±10 base pairs with Sanger confirmation of all pathogenic and likely pathogenic variants.
| Feature | Our CD3E NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity; 100% coverage of CD3E exons ±10 bp | Variable coverage; often <95% in GC‑rich regions |
| Methodology | Targeted NGS (Illumina®) with Sanger confirmation of all pathogenic/likely pathogenic variants | Broad WES; incidental findings may complicate result interpretation |
| Turnaround | 3‑4 Weeks | 4‑6 Weeks |
| Cost | 2800 AED | ~4500‑6000 AED |
| Clinical Focus | Confirms Immunodeficiency 18 only, avoiding diagnostic noise | Screens for multiple conditions, often requiring additional validation |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh – Consultant Medical Genetics (DHA ID: 9294403) notes: “A positive CD3E variant alone does not equate to clinical disease; this result must be interpreted alongside the patient’s immunological phenotype and family history. Early diagnosis allows life‑saving interventions such as haematopoietic stem cell transplantation, making timely genetic confirmation critical.”
Advisory Precautions
Medication Continuity Advisory
Do not discontinue any prescribed medication—especially immunosuppressants, antibiotics, or immunoglobulin therapy—without consulting your physician before, during, or after this test.
Exclusion Criteria & Emergency Red Flags
- Recent blood transfusion (<4 weeks) or active haematopoietic stem cell transplant may affect lymphocyte source DNA.
- Severe acute infection requiring ICU care—test after clinical stabilisation.
- Known chimerism from previous transplant complicates interpretation.
- If the patient exhibits signs of acute decompensation (persistent fever, septic shock, respiratory distress), proceed to the nearest emergency department immediately; do not delay for genetic testing.
Patient FAQ & Clinical Guidance
1. What exactly does the CD3E gene test detect, and how reliable is it?
This NGS‑based test detects single nucleotide variants and small insertions/deletions in the CD3E gene that cause Immunodeficiency Type 18, with a 99.9% diagnostic sensitivity when combined with Sanger confirmation. It identifies both known pathogenic mutations and novel likely pathogenic changes, enabling definitive molecular diagnosis. In families with a previously identified variant, it can also be used for carrier screening.
2. How long does it take to get results, and are there any preparation steps?
Sequencing and analysis of the CD3E gene require 3 to 4 weeks. A pre‑test genetic counselling session is mandatory to document family history and confirm appropriate indication. No fasting is required, but inform your physician about all medications and supplements. Results are delivered as a detailed medical report with a telephonic explanation from a certified genetic counsellor.
3. Is this test suitable for children, and what are the UAE consent requirements?
Yes, the test is indicated for paediatric patients; parental or legal guardian consent is mandatory under UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability. A paediatric genetic counsellor will guide families through the process, ensuring that the child’s personal data is handled in strict compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
UAE Regulatory & Data Privacy Adherence
All genetic testing and data handling at DNA Labs UAE strictly comply with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent is obtained in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 certification (INT/EGQ/2509DA/3139) ensures quality management systems are in place for secure, accurate diagnostic processing.
Clinical & Logistical Metadata
| Test Name | CD3E Gene (Immunodeficiency Type 18) Genetic Test – Targeted NGS with Sanger Confirmation |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available daily from 8 AM to 11 PM. |
| Methodology Used | Targeted Next-Generation Sequencing (Illumina®) with Sanger confirmation of all pathogenic/likely pathogenic variants. |
| ICD-10-CM Code | D81.8, D81.2, Z15.89 |
| LOINC Code | 101578-8 |
| DHA Facility License & Lab Address | Facility License: 1143 – DNA Labs UAE – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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