Test Price
2,800 AED✅ Home Collection Available
CD3E Gene (Immunodeficiency Type 18) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CD3E للكشف عن نقص المناعة النوع 18 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital‑Grade Home Collection with ISO‑Certified Cold‑Chain transport and VIP Mobile Phlebotomy from 8 AM – 11 PM.
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance to interpret results by a DHA‑licensed genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ملخص تنفيذي: يضمن اختبار تسلسل الجين CD3E بتقنية الجيل التالي (NGS) دقة تشخيصية فائقة وحساسية تبلغ 99.9% وفق معايير الآيزو. تشمل الخدمة سحباً منزلياً معتمداً واستشارة وراثية هاتفية بعد النتيجة.
Overview
This definitive genetic test analyses the entire coding region of the CD3E gene using next‑generation sequencing (NGS) to diagnose or rule out Immunodeficiency Type 18 (CD3ε deficiency), an autosomal recessive severe combined immunodeficiency (SCID) presenting with recurrent infections, failure to thrive, and dermatological complications.
تحليل جيني شامل لجين CD3E باستخدام التسلسل الجيني من الجيل التالي لتشخيص نقص المناعة الوراثي النوع 18، وهو اضطراب وراثي متنحٍ يظهر بأعراض جلدية وإنتانية متكررة.
| Feature | Our CD3E NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity; 100% coverage of CD3E exons ±10 bp | Variable coverage; often <95% in GC‑rich regions |
| Methodology | Targeted NGS (Illumina®) with Sanger confirmation of all pathogenic/likely pathogenic variants | Broad WES; incidental findings may complicate result interpretation |
| Turnaround | 3‑4 Weeks | 4‑6 Weeks |
| Cost | 2800 AED | ~4500‑6000 AED |
| Clinical Focus | Confirms Immunodeficiency 18 only, avoiding diagnostic noise | Screens for multiple conditions, often requiring additional validation |
Physician Insight & Safety Protocol
Dr. Prabhakar Reddy (DHA License: 61713011) notes: “A positive CD3E variant alone does not equate to clinical disease; this result must be interpreted alongside the patient’s immunological phenotype and family history. Early diagnosis allows life‑saving interventions such as haematopoietic stem cell transplantation, making timely genetic confirmation critical.”
⚠ Medication Warning:
Do not discontinue any prescribed medication—especially immunosuppressants, antibiotics, or immunoglobulin therapy—without consulting your physician before, during, or after this test.
Exclusion Criteria & Emergency Red Flags
- Recent blood transfusion (<4 weeks) or active haematopoietic stem cell transplant may affect lymphocyte source DNA.
- Severe acute infection requiring ICU care—test after clinical stabilisation.
- Known chimerism from previous transplant complicates interpretation.
- If the patient exhibits signs of acute decompensation (persistent fever, septic shock, respiratory distress), proceed to the nearest emergency department immediately; do not delay for genetic testing.
Frequently Asked Questions
1. What exactly does the CD3E gene test detect, and how reliable is it?
This NGS‑based test detects single nucleotide variants and small insertions/deletions in the CD3E gene that cause Immunodeficiency Type 18, with a 99.9% diagnostic sensitivity when combined with Sanger confirmation. It identifies both known pathogenic mutations and novel likely pathogenic changes, enabling definitive molecular diagnosis. In families with a previously identified variant, it can also be used for carrier screening.
2. كم من الوقت يستغرق ظهور النتيجة، وكيف أستعد للفحص؟
يستغرق تسلسل الجين CD3E وتحليل النتيجة 3 إلى 4 أسابيع، ويتطلب جلسة استشارة وراثية مسبقة لرسم شجرة العائلة وتوثيق التاريخ المرضي. لا حاجة للصيام، ولكن يجب إعلام الطبيب بأي أدوية أو مكملات. تُرسل النتيجة عبر تقرير طبي مفصل مع شرح هاتفي من مستشار وراثي معتمد.
3. Is this test suitable for children, and what are the UAE consent requirements?
Yes, the is indicated for paediatric patients; parental or legal guardian consent is mandatory under UAE Federal Decree‑Law No. 41 of 2024 (Art. 87) and the 2026 Child Data Safety Law. A paediatric genetic counsellor will guide families through the process, ensuring that the child’s personal data is handled in strict compliance with UAE PDPL.
Facility License: 9834453 | ISO 9001:2015 Cert: INT/EGQ/2509DA/3139
This service complies with UAE Federal Decree‑Law No. 41 of 2024 (Art. 87), CDS Law 2026 (Minors), and UAE Personal Data Protection Law (PDPL).
2026 ICD-10-CM: D81.8 (Immunodeficiency 18), D81.2 (SCID with low/normal B‑cells), Z15.89 (Genetic susceptibility to other disease) | LOINC: 101578-8
Contact: +971 54 548 8731
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