Test Price
2,800 AED✅ Home Collection Available
FLG Gene Ichthyosis Vulgaris Genetic Test in UAE DNA Labs UAE · DHA Licensed · ISO 9001:2015 Certified
Executive Summary & Core Metrics
Comprehensive FLG Gene Sequencing for Ichthyosis Vulgaris Diagnosis
- Diagnostic Accuracy: Full coding region sequencing via NGS with >99% sensitivity for pathogenic FLG variants, enabling definitive diagnosis and family cascade screening.
- Premium Home Collection: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across Dubai and the UAE.
- Clinical Support: Post-test telephonic guidance and genetic counselling session with our DHA-licensed Consultant Medical Genetics specialist for result interpretation.
- Insurance Direct Billing: Quick pre-authorization verification via WhatsApp at +971 54 548 8731.
- Price: 2800 AED inclusive of sample collection, sequencing, bioinformatics analysis, and specialist consultation.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) assay analyzes the entire coding region and exon-intron boundaries of the filaggrin (FLG) gene, the primary genetic cause of ichthyosis vulgaris. The test detects single nucleotide variants, small insertions and deletions, and copy number alterations with high analytical sensitivity. Results support dermatologists and geneticists in confirming diagnosis, assessing inheritance risk, and guiding management of associated atopic conditions. The assay is validated under ISO 9001:2015 standards and performed at our DHA-licensed laboratory in Dubai Healthcare City.
| Aspect | Our FLG NGS Test | Alternative Targeted Genotyping |
|---|---|---|
| Precision | Full gene sequencing (all coding exons) – detects rare and novel variants, including those missed by targeted panels | Limited to common mutations (e.g., R501X, 2282del4); misses ~30% of pathogenic FLG variants |
| Methodology | Next-Generation Sequencing (NGS), coverage >100× depth, ISO 9001:2015 validated workflow | PCR-based RFLP or Sanger sequencing of pre-selected loci only |
| Turnaround Time | 3–4 weeks (expedited 2-week option available for urgent clinical cases) | 2–3 weeks |
| Clinical Utility | Definitive diagnosis, cascade testing for at-risk relatives, and risk stratification for atopic dermatitis and comorbidities | Confirms only known familial mutations; limited utility in atypical presentations or sporadic cases |
Physician Insight & Safety Protocols
"As a DHA-licensed Consultant Medical Genetics specialist, I emphasize that comprehensive FLG gene sequencing through NGS provides the highest diagnostic yield for ichthyosis vulgaris. Correlation with clinical skin findings, family history, and pedigree analysis remains essential. A positive result clarifies the diagnosis and enables precise genetic counselling regarding autosomal semi-dominant inheritance. A negative result does not rule out other forms of ichthyosis or non-genetic xerotic skin conditions; further dermatological evaluation may be warranted."
"Variants of uncertain significance require expert interpretation. We strongly recommend a post-test telephonic session with our genetics team to fully understand the implications for the patient and their family. All clinical decisions regarding emollients, keratolytics, or systemic therapies should remain under the guidance of the treating dermatologist."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory Notice
Important Medication and Treatment Guidance
Do not discontinue any prescribed topical retinoids, keratolytics, emollients, or systemic immunosuppressants without consulting your treating physician. This genetic test is a diagnostic aid and does not replace ongoing dermatological care or clinical monitoring. Continue all current treatments unless your doctor advises otherwise based on test results.
Patient Exclusion Criteria & Safety Red Flags
- Exclusion Criteria: Active severe skin infection at the proposed venipuncture site; known allergy to antiseptics used during blood collection; inadequate venous access without an alternative method (FTA card may be accepted with prior approval from the laboratory).
- Emergency Red Flags: If you experience sudden widespread blistering, extensive skin peeling, signs of systemic infection such as fever or chills, or severe pain following sample collection, seek emergency medical care immediately or contact our helpline.
- Sample Integrity Requirements: Whole blood (EDTA tube), extracted DNA, or a single drop of blood on an FTA card are acceptable. Samples must be collected by a qualified phlebotomist using the provided collection kit to prevent DNA degradation and ensure result accuracy.
- Consent for Minors: In accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability, a parent or legal guardian must provide written informed consent and attend the pre-test genetic counselling session for any individual under 18 years of age.
Patient FAQ & Clinical Guidance
1. What exactly does the FLG gene NGS test diagnose, and how accurate is it?
This test performs comprehensive sequencing of the FLG gene to identify pathogenic variants that confirm ichthyosis vulgaris with greater than 99% diagnostic sensitivity for known disease-causing mutations. It is the most definitive molecular method available to differentiate ichthyosis vulgaris from other dry skin conditions, enabling precise clinical management, prognostic assessment, and genetic counselling for affected families.
2. Why does the result take 3–4 weeks, and can the process be expedited?
The laboratory follows a rigorous workflow including NGS library preparation, high-depth sequencing, bioinformatics alignment and variant calling, and manual clinical interpretation by a molecular geneticist. Each variant is cross-referenced against the latest genomic databases and peer-reviewed literature. Standard turnaround is 3–4 weeks to guarantee result integrity. An expedited 2-week option may be authorized for urgent diagnostic or preoperative cases upon request from your referring physician.
3. Does health insurance cover the cost of this genetic test in the UAE?
Many UAE health insurance plans provide full or partial coverage for FLG genetic testing when medically indicated and referred by a licensed physician. Prior approval from the insurer is required before sample collection. Contact our billing team via WhatsApp at +971 54 548 8731 for immediate verification of your insurance coverage and any applicable co-payment or deductible. Self-requested screening without a physician referral may not be eligible for reimbursement.
4. What are the pre-test requirements, and do I need to fast or stop medications?
A detailed clinical history and a signed test request form from a licensed physician are mandatory. A pre-test genetic counselling session to document a three-generation pedigree and assess family history of ichthyosis vulgaris or atopic conditions is strongly recommended and is required for all minors. No fasting or dietary restrictions are needed. Continue all prescribed medications unless your doctor specifically instructs otherwise. The sample can be collected at any time of day.
UAE Regulatory & Data Privacy Adherence
Data Protection & Legal Compliance: All genetic testing and data processing at DNA Labs UAE are conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Genetic information is stored on encrypted servers, accessible only to authorized clinical personnel, and processed exclusively for diagnostic purposes with your explicit written consent. Our facility holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License Number 1143. You have the right to access your data, request correction, and withdraw consent at any time in accordance with UAE law.
Clinical & Logistical Metadata
| Test Name | FLG Gene Sequencing – Ichthyosis Vulgaris Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (expedited 2-week option available for urgent cases) |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card blood spot – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – full coding region and exon-intron boundaries, >100× coverage depth, ISO 9001:2015 validated |
| ICD-10-CM Code | Q80.0 (Ichthyosis vulgaris) |
| LOINC Code | 86635-0 (Genetic analysis nucleic acid sequencing) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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