Test Price
2,800 AED✅ Home Collection Available
SMAD4 Gene Juvenile Polyposis Syndrome Genetic Test in Dubai
Executive Summary & Core Metrics
Diagnostic precision with patient‑centric care.
- Accuracy Guarantee: 99.9% diagnostic sensitivity using ISO‑certified Next‑Generation Sequencing (NGS) at our DHA‑licensed laboratory (License 1143).
- Premium Logistics: Complimentary VIP mobile phlebotomy & temperature‑controlled cold‑chain home collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic post‑test interpretation by a DHA‑licensed Consultant Medical Genetics included.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This NGS test analyses the SMAD4 tumour‑suppressor gene to detect pathogenic mutations causing Juvenile Polyposis Syndrome (JPS) — a hereditary condition marked by hamartomatous polyps and significantly elevated colorectal cancer risk. Early molecular diagnosis enables tailored surveillance and risk‑reducing interventions. The complete coding region, intron‑exon boundaries, and selected deep intronic regions are interrogated, providing comprehensive variant detection.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS), full gene | Single‑gene Sanger sequencing |
| Coverage | All exons, intron‑exon boundaries, deep intronic variants | Only pre‑specified hotspots |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks (for full gene) |
| Variant Detection Sensitivity | >99.9% for substitutions and small indels | ~95% for targeted regions |
| Price (AED) | 2,800 | Often >2,500 for complete analysis |
Physician Insight & Safety Protocols
“A positive SMAD4 mutation identifies a clear hereditary predisposition, but it must always be interpreted alongside clinical findings and family history. A negative result does not eliminate other genetic causes of polyposis. Surveillance and treatment decisions should never be altered without direct consultation with your managing physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Advisory
Do not discontinue any prescribed medication or initiate self-treatment based on genetic test results without first consulting your doctor. Genetic test results are one component of a comprehensive medical evaluation.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed)
- Active uncontrolled bleeding disorder
- Severe anaemia (Hb <7 g/dL)
- Inability to provide informed consent (e.g., dementia, acute psychosis)
- Recent major surgery (<6 weeks)
ER Red Flags – Seek Immediate Medical Care If You Experience:
- Sudden, severe abdominal pain
- Bright red rectal bleeding
- Unexplained weight loss (>5% in one month)
- Persistent vomiting or signs of bowel obstruction
Patient FAQ & Clinical Guidance
1. What does the SMAD4 gene test diagnose?
This next-generation sequencing test detects pathogenic variants in the SMAD4 gene that cause hereditary juvenile polyposis syndrome, empowering personalized cancer surveillance and family screening. A negative result does not exclude all hereditary risks.
2. How is the sample collected and when will I receive the results?
A licensed phlebotomist draws a small blood sample or collects a drop of blood on an FTA card during a home visit; the final NGS report is securely delivered within 3–4 weeks. VIP mobile phlebotomy is available daily from 8 AM to 11 PM.
3. Is this covered by UAE health insurance?
Most UAE insurers reimburse diagnostic NGS testing for hereditary cancer syndromes when clinical criteria are met; our team verifies your coverage beforehand via WhatsApp at +971 54 548 8731.
UAE Regulatory & Data Privacy Adherence
Trust & Compliance
DNA Labs UAE operates under DHA Facility License No. 1143 and fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields to ensure the confidentiality and security of your genetic data and health information. Clinical testing safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic results are reviewed by a licensed Consultant Medical Genetics before release.
Clinical & Logistical Metadata
| Test Name | SMAD4 Gene Juvenile Polyposis Syndrome Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL EDTA) or FTA card (dried blood spot) |
| Methodology Used | Next‑Generation Sequencing (NGS), full gene sequencing |
| ICD-10-CM Code | Q85.09 (Other hamartomatous polyposis syndromes) |
| LOINC Code | 81247-9 (SMAD4 gene mutation analysis) |
| DHA Facility License & Laboratory Address | License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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التحقق من التغطية التأمينية
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians