Test Price
2,800 AED✅ Home Collection Available
SMAD4 Gene Juvenile Polyposis Syndrome Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SMAD4 لمتلازمة السلائل اليفعي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary – Diagnostic precision with patient‑centric care.
- Accuracy Guarantee: 99.9% diagnostic sensitivity using ISO‑certified Next‑Generation Sequencing (NGS) at our DHA‑licensed laboratory.
- Premium Logistics: Complimentary hospital‑grade home collection (8 AM – 11 PM) with ISO 9001 cold‑chain transport and VIP mobile phlebotomy.
- Clinical Guidance: Telephonic post‑test interpretation by a DHA‑licensed genetic counsellor included.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
ملخص تنفيذي: تحليل جين SMAD4 بتقنية التسلسل الجيني المتقدم (NGS) بدقة تشخيصية 99.9%، مع خدمة سحب منزلي معتمدة، واستشارة وراثية هاتفية بعد الفحص، وتحقق من تغطية التأمين عبر واتساب.
Overview of SMAD4 Gene Juvenile Polyposis Syndrome Test
This NGS test analyses the SMAD4 tumour‑suppressor gene to detect mutations causing Juvenile Polyposis Syndrome (JPS) — a hereditary condition marked by hamartomatous polyps and significantly elevated colorectal cancer risk. Early molecular diagnosis enables tailored surveillance and risk‑reducing interventions. (هذا الفحص يحلل جين SMAD4 للكشف عن الطفرات المسببة لمتلازمة السلائل اليفعي الوراثية، مما يساعد في الكشف المبكر وتقليل خطر السرطان).
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS), full gene | Single‑gene Sanger sequencing |
| Coverage | All exons, intron‑exon boundaries, deep intronic variants | Only pre‑specified hotspots |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks (for full gene) |
| Variant Detection Sensitivity | >99.9% for substitutions and small indels | ~95% for targeted regions |
| Price (AED) | 2,800 | Often >2,500 for complete analysis |
Physician Insight & Safety Protocol
“A positive SMAD4 mutation identifies a clear hereditary predisposition, but it must always be interpreted alongside clinical findings and family history. A negative result does not eliminate other genetic causes of polyposis. Surveillance and treatment decisions should never be altered without direct consultation with your managing physician.”
— Dr. Prabhakar Reddy, DHA License 61713011 (Consultant Clinical Geneticist)
⚠️ Medication Warning:
Do not discontinue any prescribed medication or initiate self-treatment based on genetic test results without first consulting your doctor.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed)
- Active uncontrolled bleeding disorder
- Severe anaemia (Hb <7 g/dL)
- Inability to provide informed consent (e.g., dementia, acute psychosis)
- Recent major surgery (<6 weeks)
ER Red Flags – Seek Immediate Medical Care If You Experience:
- Sudden, severe abdominal pain
- Bright red rectal bleeding
- Unexplained weight loss (>5% in one month)
- Persistent vomiting or signs of bowel obstruction
Frequently Asked Questions
1. What does the SMAD4 gene test diagnose?
This next-generation sequencing test detects pathogenic variants in the SMAD4 gene that cause hereditary juvenile polyposis syndrome, empowering personalized cancer surveillance and family screening. A negative result does not exclude all hereditary risks.
هذا الفحص يكشف الطفرات المرضية في جين SMAD4 المسببة لمتلازمة السلائل اليفعي الوراثي، مما يمكّن من المراقبة المخصصة وتقليل المخاطر.
2. How is the sample collected and when will I receive the results?
A licensed phlebotomist draws a small blood sample or collects a drop of blood on an FTA card during a home visit; the final NGS report is securely delivered within 3‑4 weeks.
يتم سحب عينة دم وريدية أو بقعة بطاقة FTA منزلياً على يد ممارس صحي مرخص، وتصدر النتيجة خلال 3‑4 أسابيع عبر تقرير آمن.
3. Is this covered by UAE health insurance?
Most UAE insurers reimburse diagnostic NGS testing for hereditary cancer syndromes when clinical criteria are met; our team verifies your coverage beforehand via WhatsApp at +971 54 548 8731.
غالباً ما تغطي شركات التأمين في الإمارات الفحوصات الجينية التشخيصية عند توفر المعايير السريرية، وسنتحقق من تغطيتك قبل الفحص عبر واتساب.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians