Test Price
2,800 AEDโ Home Collection Available
PMS1 Gene Lynch Syndrome NGS Test in UAE | 2,800 AED | DHA Compliant
Executive Summary & Core Metrics
Executive Summary
The PMS1 Gene Lynch Syndrome NGS Test employs Next Generation Sequencing to detect pathogenic variants in the PMS1 gene, enabling precise hereditary cancer risk assessment. This DHA-licensed assay delivers 99.9% diagnostic sensitivity through ISO-accredited processing at DNA Labs UAE.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM โ 11 PM).
- Clinical Guidance: Telephonic Post-Test Genetic Counselling included for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This NGS-based assay provides comprehensive analysis of the PMS1 gene covering all exons and intron-exon boundaries, delivering superior variant detection compared to traditional Sanger sequencing. The test supports early identification of Lynch syndrome susceptibility, empowering patients and clinicians with actionable genomic data for tailored surveillance and preventive care. A turnaround time of 3โ4 weeks ensures thorough bioinformatic analysis and clinical validation.
| Feature | Our PMS1 NGS Test | Sanger Sequencing (Alternative) |
|---|---|---|
| Method | Next Generation Sequencing (NGS) | Sanger Sequencing |
| Coverage | Full gene (all exons, intron-exon boundaries) | Limited to hotspot regions |
| Turnaround Time | 3โ4 Weeks | 6โ8 Weeks |
| Diagnostic Yield | High (comprehensive variant detection) | Moderate |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
โAs a Consultant Medical Genetics, I recognize the emotional weight that accompanies hereditary cancer risk assessment. The PMS1 gene NGS test provides a critical foundation for identifying Lynch syndrome susceptibility, enabling evidence-based surveillance and preventive strategies. A positive result is not a cancer diagnosis but a call to action for tailored clinical monitoring, family cascade testing, and informed lifestyle decisions. I strongly advise all patients to discuss their results with a genetic counsellor or oncologist to ensure comprehensive clinical correlation and personalized management.โ
Clinical Advisory Protocols
Medication Stability & Clinical Advisory
Do not discontinue any prescribed medication without consulting your physician. This genetic test assesses hereditary susceptibility and does not replace ongoing medical management. All findings must be correlated with clinical history, imaging, and biochemical markers by a qualified specialist.
Exclusion Criteria & Emergency Red Flags
Patient Exclusion & Urgent Warning Signs
- Exclusion Criteria: Active bleeding disorder, severe anaemia (Hb <8 g/dL), acute systemic infection, inability to provide informed consent, recent blood transfusion within 2 weeks, absence of pre-test genetic counselling session.
- Emergency Red Flags: If you experience chest pain, shortness of breath, sudden severe headache, or uncontrolled bleeding at the draw site after collection, seek immediate medical attention.
Patient FAQ & Clinical Guidance
1. What is the PMS1 gene Lynch syndrome test used for?
This PMS1 NGS test identifies pathogenic gene variants that cause Lynch syndrome, an inherited condition that elevates the risk of colorectal, endometrial, and other cancers. The result guides personalized cancer surveillance intervals, preventive surgical considerations, and family cascade testing to reduce overall cancer mortality.
2. How is the sample collected and what are the requirements?
A peripheral whole blood sample, extracted DNA, or a dried blood spot on an FTA card is collected by our VIP Mobile Phlebotomy service using temperature-controlled cold-chain logistics. No fasting is required. A valid Emirates ID is necessary for registration, and all collection procedures comply with UAE infection control standards.
3. Is genetic counselling mandatory before this test?
Yes, a pre-test genetic counselling session is mandatory to construct a three-generation pedigree, assess hereditary risk, and document informed consent. Our certified genetic counsellors provide a 30-minute teleconsultation prior to sample collection, as mandated by DHA regulatory standards. Post-test counselling is also included to contextualize results within the patientโs complete clinical and family history.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Health Information Governance
All genetic data handling complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Laboratory operations are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and fully aligned with DHA and MOHAP standards for genetic testing and molecular diagnostics.
Clinical & Logistical Metadata
| Test Name | PMS1 Gene Lynch Syndrome NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, Extracted DNA, or FTA Card (Dried Blood Spot) |
| Methodology Used | Next Generation Sequencing (NGS) โ Full Gene Analysis (All Exons & Intron-Exon Boundaries) |
| ICD-10-CM Code | Z15.09 (Genetic susceptibility to other malignant neoplasm); Z80.0 (Family history of malignant neoplasm of digestive organs) |
| LOINC Code | 76918-9 (PMS1 gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians