Test Price
2,800 AED✅ Home Collection Available
MSH6 Gene (Mismatch Repair Cancer Syndrome) Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Clinical Assurance & Diagnostic Precision
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM – 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Genetic Counseling for result interpretation by DHA-licensed specialists.
- Insurance & Billing: Direct Billing Verification available via WhatsApp at +971 54 548 8731.
- Regulatory Compliance: Strict adherence to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Core Metrics: 3 to 4 Week Turnaround Time | 2,800 AED | DHA License 1143.
Test Overview & Methodology
The MSH6 Gene Genetic Test is a comprehensive molecular diagnostic assay designed to detect germline and somatic mutations in the MSH6 mismatch repair gene. This gene is a critical marker for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer – HNPCC) and significantly elevated lifetime risks for colorectal, endometrial, gastric, and ovarian cancers.
Utilizing Next Generation Sequencing (NGS), this test delivers high-resolution variant analysis covering single nucleotide variants (SNVs), small insertions or deletions (indels), and copy number variations (CNVs). Clinical reporting is aligned to ACMG or AMP variant interpretation guidelines and stringent DHA or MOHAP standards.
| Feature | Our MSH6 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | NGS – Full Gene Coverage | Sanger Sequencing – Targeted Exon Analysis |
| Variant Detection | SNVs, Indels, CNVs, VUS Classification | Limited to SNVs and small Indels |
| Turnaround Time (TAT) | 3 to 4 Weeks | 4 to 6 Weeks |
| Clinical Sensitivity | 99.9% (ISO-Accredited) | ~95% (Limited CNV Detection) |
| Price | 2,800 AED | 1,800 – 2,400 AED |
Physician Insight & Clinical Safety Protocols
"A genetic test result is a powerful piece of your health puzzle, but it must be interpreted within the full context of your personal and family medical history. I strongly counsel every patient who undergoes MSH6 testing to view the outcome as a guide for enhanced surveillance and proactive risk management—not a definitive diagnosis—and to discuss all findings with a board-certified genetic counselor or oncologist before making any medical decisions."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Advisory Notice
⚠️ CRITICAL NOTICE: Do not discontinue, alter, or pause any prescribed medication—including anticoagulants, chemotherapy agents, or hormonal therapies—without explicit consultation with your treating physician. This genetic test does not replace ongoing oncological management or routine cancer screening protocols.
Patient Safety: Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed Without Physician Clearance):
- Recent blood transfusion (within 14 days prior to sample collection).
- Current active systemic infection or febrile illness (≥38.5°C).
- Known bone marrow transplant recipient (donor DNA may confound results).
- Inability to provide valid informed consent per UAE legal standards.
- Minors (under 18 years) without court-approved legal guardian authorization.
ER Red Flags – Seek Immediate Medical Attention:
- Acute, unexplained rectal bleeding or melena (black, tarry stools).
- Severe abdominal pain with distention or obstruction symptoms.
- Unexplained, significant weight loss (>10% body mass in 90 days).
- New-onset persistent change in bowel habits lasting longer than 3 weeks.
- Postmenopausal or intermenstrual vaginal bleeding.
Patient FAQ & Clinical Guidance
1. What is the MSH6 gene and why is this genetic test critical for cancer risk assessment?
The MSH6 gene encodes a DNA mismatch repair (MMR) protein essential for correcting replication errors. Pathogenic mutations significantly elevate lifetime risk for Lynch Syndrome-associated colorectal, endometrial, and gastric cancers. This NGS-based test comprehensively sequences the entire MSH6 coding region to identify deleterious germline variants, enabling proactive risk-reduction strategies including intensified colonoscopic surveillance beginning as early as age 20 to 25, prophylactic surgical consultations, and cascade testing for at-risk blood relatives.
جين MSH6 مسؤول عن إنتاج بروتين إصلاح عدم التطابق في الحمض النووي، والطفرات الممرضة فيه تزيد من خطر الإصابة بمتلازمة لينش وسرطان القولون والمستقيم. يساعد هذا الفحص في وضع خطة مراقبة دورية ووقاية شخصية.
2. How is the MSH6 NGS test performed and what sample types are accepted?
A simple peripheral venous blood draw using an EDTA tube, extracted genomic DNA, or a single drop of blood on an FTA card is collected by a DHA-licensed phlebotomist via VIP Mobile Phlebotomy. The sample undergoes library preparation, target enrichment, and high-depth NGS on validated platforms. Bioinformatics pipelines align reads to the GRCh38/hg38 reference genome with variant calling performed at a minimum depth of 100x coverage across all MSH6 exons and splice junctions. Results are interpreted by board-certified molecular geneticists and delivered within 3 to 4 weeks.
يتم جمع عينة دم وريدي بسيطة أو استخدام الحمض النووي المستخلص، ثم تحليلها بتقنية التسلسل الجيني المتقدم لتغطية كامل مناطق جين MSH6. تصدر النتائج خلال 3 إلى 4 أسابيع.
3. What do my MSH6 genetic test results mean and what are the next steps?
Results classify identified variants as Pathogenic, Likely Pathogenic, Variant of Uncertain Significance (VUS), Likely Benign, or Benign, with pathogenic findings confirming elevated cancer risk requiring personalized screening protocols. A positive result triggers a referral to a multidisciplinary team including an oncologist, gastroenterologist, and genetic counselor for a tailored surveillance plan encompassing annual colonoscopy, transvaginal ultrasound, and consideration of risk-reducing surgery. A negative result in the context of a known familial mutation effectively rules out that specific risk. VUS results necessitate periodic reanalysis as scientific knowledge evolves. All patients receive complimentary post-test telephonic clinical guidance.
تصنف النتائج الطفرات إلى ممرضة أو محتملة الضرر أو غير محددة الأهمية، وفي حال وجود طفرة ممرضة يتم وضع خطة مراقبة دورية تشمل تنظير القولون السنوي والفحوصات الدورية.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic data is anonymized, encrypted, and securely processed. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our DHA Facility License (No. 1143) ensures all genomic testing and reporting meets the highest standards of clinical governance and patient confidentiality.
Clinical & Logistical Metadata
| Test Name | MSH6 Gene (Mismatch Repair Cancer Syndrome) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted Genomic DNA, or FTA Card Dried Blood Spot |
| Methodology Used | Next Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | Z15.09 (Genetic Susceptibility to Other Malignant Neoplasm), Z80.49 (Family history of other digestive organ cancers) |
| LOINC Code | 94122-9 (MSH6 gene targeted mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians