Test Price
2,800 AED✅ Home Collection Available
MSH6 Gene (Mismatch Repair Cancer Syndrome) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين MSH6 لمتلازمة السرطان المرتبطة بخلل إصلاح عدم التطابق بتقنية التسلسل الجيني المتقدم في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي 2026
Executive Summary & Clinical Assurance
ملخص تنفيذي: فحص جين MSH6 باستخدام تقنية التسلسل الجيني المتقدم (NGS) للكشف عن الطفرات الممرضة المرتبطة بمتلازمة لينش وسرطان القولون والمستقيم الوراثي وسرطان بطانة الرحم. دقة تشخيصية بنسبة 99.9% وفق معايير الآيزو والتشريعات الصحية الاتحادية.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection (8 AM – 11 PM) & VIP Mobile Phlebotomy.
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed specialists.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
- Regulatory Compliance: Strict adherence to Federal Decree-Law No. 41 of 2024 (Art. 87), UAE CDS Law 2026 (Minors), and UAE PDPL (Data Privacy).
Overview: MSH6 Genetic Testing for Hereditary Cancer Risk
The MSH6 Gene Genetic Test is a comprehensive molecular diagnostic assay designed to detect germline and somatic mutations in the MSH6 mismatch repair gene, a key marker for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer – HNPCC) and increased lifetime risk of colorectal, endometrial, gastric, and ovarian cancers. يكتشف هذا الفحص الطفرات الجينية في جين إصلاح عدم التطابق MSH6 لتقييم القابلية الوراثية للإصابة بالسرطان.
Utilizing Genetic Test delivers high-resolution variant analysis covering single nucleotide variants (SNVs), small insertions/deletions (indels), and copy number variations (CNVs), with clinical reporting aligned to 2026 DHA/MOHAP standards and ACMG/AMP variant interpretation guidelines.
| Feature | Our MSH6 NGS Test | Closest Alternative (Sanger Sequencing / Single-Gene) |
|---|---|---|
| Methodology | NGS (Next Generation Sequencing) – Full Gene Coverage | Sanger Sequencing – Targeted Exon Analysis |
| Variant Detection | SNVs, Indels, CNVs, VUS classification | Limited to SNVs and small Indels in targeted regions |
| Turnaround Time (TAT) | 3 to 4 Weeks | 4 to 6 Weeks |
| Clinical Sensitivity | 99.9% (ISO-Accredited) | ~95% (Limited CNV detection) |
| Price | 2800 AED | 1800 – 2400 AED |
Physician Insight & Clinical Safety Protocol
“A genetic test result is a powerful piece of your health puzzle, but it must be interpreted within the full context of your personal and family medical history. I strongly counsel every patient who undergoes MSH6 testing to view the outcome as a guide for enhanced surveillance—not a definitive sentence—and to discuss all findings with a board-certified oncologist or genetic counselor before making any medical decisions.”
— Dr. PRABHAKAR REDDY, DHA License No. 61713011, Laboratory Medicine & Clinical Genomics
⚠️ CRITICAL NOTICE: Do not discontinue, alter, or pause any prescribed medication—including anticoagulants, chemotherapy agents, or hormonal therapies—without explicit consultation with your treating physician. This genetic test does not replace ongoing oncological management or routine cancer screening protocols.
Patient Safety: Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed Without Physician Clearance):
- Recent blood transfusion (within 14 days prior to sample collection).
- Current active systemic infection or febrile illness (≥38.5°C).
- Known bone marrow transplant recipient (donor DNA may confound results).
- Inability to provide valid informed consent per UAE CDS Law 2026.
- Minors (under 18 years) without court-approved legal guardian authorization.
ER Red Flags – Seek Immediate Medical Attention Regardless of Test Results:
- Acute, unexplained rectal bleeding or melena (black, tarry stools).
- Severe abdominal pain with distention or obstruction symptoms.
- Unexplained, significant weight loss (>10% body mass in 90 days).
- New-onset persistent change in bowel habits lasting >3 weeks.
- Postmenopausal or intermenstrual vaginal bleeding.
Pre-Test Requirements & Genetic Counseling Protocol
- A detailed Clinical History intake including personal cancer history and prior surgical or chemotherapeutic interventions.
- Mandatory Genetic Counseling session to construct a three-generation pedigree chart documenting all family members affected by MSH6-associated cancers (colorectal, endometrial, gastric, ovarian, urothelial).
- Signed informed consent form compliant with UAE PDPL and Federal Decree-Law No. 41 of 2024 data privacy provisions.
- No fasting required. No medication adjustments are necessary for blood collection. Avoid heparin-based anticoagulants in the collection tube if using whole blood; EDTA tubes are preferred.
Patient FAQ & Clinical Guidance
Q1: What is the MSH6 gene and why is this Genetic Test critical for cancer risk assessment?
The MSH6 gene encodes a DNA mismatch repair (MMR) protein essential for correcting replication errors; pathogenic mutations significantly elevate lifetime risk for Lynch Syndrome-associated colorectal, endometrial, and gastric cancers. This NGS-based test comprehensively sequences the entire MSH6 coding region to identify deleterious germline variants, enabling proactive risk-reduction strategies including intensified colonoscopic surveillance beginning as early as age 20–25, prophylactic surgical consultations, and cascade testing for at-risk blood relatives.
جين MSH6 مسؤول عن إنتاج بروتين إصلاح عدم التطابق في الحمض النووي، والطفرات الممرضة فيه تزيد من خطر الإصابة بمتلازمة لينش وسرطان القولون والمستقيم وسرطان بطانة الرحم. يساعد هذا الفحص في وضع خطة مراقبة دورية ووقاية شخصية.
Q2: How is the MSH6 NGS test performed and what sample types are accepted?
A simple peripheral venous blood draw (EDTA tube), extracted genomic DNA, or a single drop of blood on an FTA card is collected by a DHA-licensed phlebotomist via hospital-grade home collection service. The sample undergoes library preparation, target enrichment, and high-depth Next Generation Sequencing on validated platforms. Bioinformatics pipelines align reads to the GRCh38/hg38 reference genome with variant calling performed at a minimum depth of 100x coverage across all MSH6 exons and splice junctions. Results are interpreted by board-certified molecular geneticists and delivered within 3 to 4 weeks.
يتم جمع عينة دم وريدي بسيطة أو استخدام الحمض النووي المستخلص أو بطاقة FTA، ثم تحليلها بتقنية التسلسل الجيني المتقدم (NGS) لتغطية كامل مناطق جين MSH6. تصدر النتائج خلال 3 إلى 4 أسابيع.
Q3: What do my MSH6 genetic test results mean and what are the next steps?
Results classify identified variants as Pathogenic, Likely Pathogenic, Variant of Uncertain Significance (VUS), Likely Benign, or Benign, with pathogenic findings confirming elevated cancer risk requiring personalized screening protocols. A positive (pathogenic) result triggers referral to a multidisciplinary team including an oncologist, gastroenterologist, and genetic counselor for creation of a tailored surveillance plan encompassing annual colonoscopy, transvaginal ultrasound, and consideration of risk-reducing surgery. A negative result in the context of a known familial mutation effectively rules out that specific risk. VUS results necessitate periodic reanalysis as scientific knowledge evolves. All patients receive complimentary post- telephonic clinical guidance for result interpretation.
تصنف النتائج الطفرات إلى ممرضة أو محتملة الضرر أو غير محددة الأهمية أو حميدة، وفي حال وجود طفرة ممرضة يتم وضع خطة مراقبة دورية تشمل تنظير القولون السنوي والفحوصات النسائية الدورية واستشارة الفريق الطبي متعدد التخصصات.
Specimen & Logistics Summary
- Accepted Samples: Whole Blood (EDTA), Extracted Genomic DNA, or One Drop Blood on FTA Card.
- Turnaround Time: 3 to 4 Weeks from sample receipt.
- Home Collection: Available daily 8 AM – 11 PM. ISO-Certified Cold-Chain Transport.
- Price: 2800 AED (Direct Billing Insurance Verification Available).
- Support: WhatsApp +971 54 548 8731
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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