Test Price
2,800 AED✅ Home Collection Available
MLH1 Gene (Hereditary Nonpolyposis Colorectal Cancer, Lynch Syndrome) Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation with a Consultant Medical Genetics.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This MLH1 gene analysis employs Next-Generation Sequencing (NGS) to detect germline mutations associated with hereditary nonpolyposis colorectal cancer (Lynch syndrome). The assay covers the full coding region with ±10 bp of intron/exon boundaries, enabling identification of point mutations, small insertions/deletions, and copy-number variants. Results guide lifetime cancer screening intervals, risk-reducing interventions, and family cascade testing.
| Feature | Our Test: MLH1 NGS (UAE) | Closest Alternative: Single-Gene Sanger Sequencing |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity for point mutations, small indels, and copy-number changes | ~99.0% – limited to small coding regions, may miss large rearrangements |
| Methodology | NGS (Next-Generation Sequencing) covering full coding region ±10 bp of intron/exon boundaries | Sanger sequencing of selected exons |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Price | 2800 AED (inclusive of genetic counselling session) | ~2000–2500 AED (often excludes interpretation) |
| Sample | Whole Blood, Extracted DNA, or FTA Card Specimen | Blood (3–5 mL EDTA tube) |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I consider MLH1 gene analysis a cornerstone of hereditary colorectal cancer risk assessment. This NGS-based test provides comprehensive detection of pathogenic variants that inform personalised surveillance schedules and preventive strategies for patients and their families. It is essential, however, that every result is interpreted within the full context of personal and family history. A negative result does not rule out hereditary cancer risk, and all findings warrant professional genetic counselling for accurate clinical translation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Advisory
Exclusion Criteria & Emergency Red Flags
Before Scheduling the Test:
- Acute illness or recent major surgery (wait 4 weeks).
- Active chemotherapy or radiotherapy (discuss timing with oncologist).
- Current diagnosis of haematological malignancy without specialist clearance.
- Age below 18 years requires legal guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Seek Emergency Care If You Experience:
- Unexplained rectal bleeding or melena.
- Severe, persistent abdominal pain or distension.
- Unintentional weight loss >5% in 4 weeks.
- Sudden change in bowel habits lasting >2 weeks.
This test is elective; if you have acute symptoms, visit the nearest emergency room immediately.
Patient FAQ & Clinical Guidance
1. What is the MLH1 gene test and who should consider it?
The MLH1 genetic test detects inherited mutations that significantly increase Lynch syndrome and colorectal cancer risk. It is recommended for individuals with a personal or family history of colorectal or endometrial cancer diagnosed before age 50, multiple Lynch-spectrum cancers in the family, or known MLH1 mutation carriers. A positive result enables tailored screening intervals and risk-reduction strategies for the patient and at-risk relatives.
2. How is the test performed and what does the 3–4 week turnaround involve?
A simple blood draw or FTA card sample is processed by next-generation sequencing, analyzing all coding regions of the MLH1 gene. After collection, DNA is extracted, libraries are prepared, and sequencing is performed to a depth exceeding 1000× for high accuracy. The 3–4 week interval allows for thorough bioinformatic analysis, variant classification per ACMG guidelines, and a double-validation step before the final clinical report is issued.
3. How should I prepare, and is genetic counselling required?
Pre-test genetic counselling to construct a detailed family pedigree is mandatory and included in your package. Provide your clinician with a complete family cancer history spanning first- and second-degree relatives. No fasting is required, but anticoagulants may need temporary adjustment under medical supervision. Continue all prescribed medications unless your doctor advises otherwise. Post-test counselling is also provided to discuss results and their implications.
UAE Regulatory & Data Privacy Adherence
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic data is encrypted, stored onshore, and processed in compliance with UAE data protection regulations.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Digital health records and telemedicine protocols adhere to national ICT standards.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Patient consent, clinical safety, and professional accountability are strictly enforced.
- ISO 9001:2015 Certified: Certificate INT/EGQ/2509DA/3139 guarantees quality management from sample collection to reporting.
Clinical & Logistical Metadata
| Test Name | MLH1 Gene (Hereditary Nonpolyposis Colorectal Cancer, Lynch Syndrome) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card Specimen — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS), Full Coding Region ±10 bp Intron/Exon Boundaries |
| ICD-10-CM Code | Z15.09, Z80.0 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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