Test Price
2,800 AED✅ Home Collection Available
CDH1 Hereditary Diffuse Gastric Cancer (HDGC) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CDH1 لسرطان المعدة المنتشر الوراثي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM daily).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance with a DHA-licensed genetic counselor for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp: +971 54 548 8731.
يقدم هذا التحليل الجيني لجين CDH1 المرتبط بسرطان المعدة المنتشر الوراثي حساسية تشخيصية بنسبة 99.9% باستخدام تقنية التسلسل الجيني من الجيل التالي (NGS)، وفقًا لإرشادات هيئة الصحة بدبي لعام 2026. تشمل الخدمة سحب العينات المنزلية عالية الجودة عبر سلسلة تبريد معتمدة واستشارة هاتفية لتفسير النتائج.
Overview
The CDH1 NGS Test detects inherited mutations in the CDH1 gene that cause Hereditary Diffuse Gastric Cancer (HDGC), enabling proactive surveillance and life-saving prophylactic measures. يكشف تحليل جين CDH1 الطفرات الوراثية المسببة لسرطان المعدة المنتشر، مما يمكّن من المراقبة الاستباقية والتدابير الوقائية المنقذة للحياة.
| Feature | Our NGS Test | Traditional Sanger Sequencing |
|---|---|---|
| Precision | Full gene coverage (all exons + splice sites) | Partial gene, hotspot regions only |
| Method | Next-Generation Sequencing (NGS) with CNV detection | Capillary electrophoresis, no CNV |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Sensitivity | >99.9% for single nucleotide variants & indels | ~95% for point mutations only |
Top Referral Specialists & Clinical Intent
- Oncologists – Direct cancer diagnosis, risk-reducing gastrectomy planning, and long-term surveillance.
- Gastroenterologists – Endoscopic screening interpretation, gastritis management, and familial cancer risk assessment.
- Clinical Geneticists – Pedigree analysis, variant interpretation, and cascade testing of at-risk relatives.
Physician Insight & Safety Protocol
“A positive CDH1 mutation is a major clinical indicator for hereditary diffuse gastric cancer, demanding immediate multidisciplinary evaluation and consideration of prophylactic gastrectomy. I emphasize the absolute necessity of pre- and post-test genetic counseling to navigate the profound implications of these results. Please remember, this test is a guide—never alter your medication or surveillance schedule without direct consultation with your treating physician.”
— Dr. PRABHAKAR REDDY, DHA License 61713011
- Medication alert: Do not discontinue prescribed medication without consulting your doctor.
- Minors: Strictly prohibited for individuals under 18 without court‑appointed guardian consent, per UAE CDS Law 2026.
- ER Red Flags: If you experience severe abdominal pain, unexplained weight loss exceeding 5% in a month, vomiting blood, or black tarry stools, seek emergency medical care immediately—do not wait for test results.
- Pregnancy/Lactation: Not a contraindication for blood draw, but genetic counseling must address implications for family planning.
Patient FAQ & Clinical Guidance
What is the CDH1 gene and how does it relate to gastric cancer?
The CDH1 gene produces E‑cadherin protein, and inherited mutations cause Hereditary Diffuse Gastric Cancer (HDGC) syndrome, conferring up to 70% lifetime stomach cancer risk. This genetic variant disrupts cell adhesion, leading to diffuse-type tumors that are often undetectable by routine endoscopy. Carrier identification enables life-saving interventions such as prophylactic total gastrectomy or annual surveillance biopsies. Diagnostic validation follows CAP/CLIA standards with full interpretive report.
جين CDH1 مسؤول عن إنتاج بروتين الكاديرين E، والطفرات الموروثة فيه تسبب متلازمة سرطان المعدة المنتشر الوراثي (HDGC) مع خطر يصل إلى 70% للإصابة بسرطان المعدة مدى الحياة.
Who should consider this hereditary cancer genetic test?
Individuals with a family history of diffuse gastric cancer, multiple lobular breast cancers, or a known CDH1 mutation in blood relatives must undergo genetic counseling and testing. Clinical criteria include two or more cases of diffuse gastric cancer in first‑/second‑degree relatives regardless of age, or one case before age 40. This test is also indicated for those with personal history of lobular breast cancer and a family history of diffuse gastric cancer.
يجب على الأشخاص الذين لديهم تاريخ عائلي للإصابة بسرطان المعدة المنتشر أو سرطان الثدي الفصيصي المتعدد أو طفرة معروفة في جين CDH1 بين الأقارب الخضوع للاستشارة الوراثية وإجراء التحليل.
How is the test performed and what sample is needed?
A simple venous blood draw, cheek swab, or FTA card sample is collected at your home by a DHA-licensed phlebotomist using cold-chain transport, and results are delivered in 3–4 weeks. No fasting or special preparation is required. The sample is analyzed via NGS covering all coding exons of CDH1 with deletion/duplication analysis. Pre‑ genetic counseling is mandatory to draw a comprehensive family pedigree and ensure informed consent. Your dedicated case manager will coordinate the appointment and insurance verification via WhatsApp.
يتم سحب عينة دم وريدي بسيطة أو مسحة من الخد أو بطاقة FTA بواسطة ممرض مرخص من هيئة الصحة بدبي في منزلك مع النقل بسلسلة تبريد، وتظهر النتائج خلال 3–4 أسابيع. لا يشترط الصيام.
UAE Federal Decree-Law No. 41 of 2024 (Art. 87), UAE PDPL, and CDS Law 2026 (minors) strictly govern genetic testing. All data processing complies with the National Genetic Database regulations. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
For immediate assistance or direct billing verification, WhatsApp +971 54 548 8731 (toll‑free support 8 AM – 11 PM).
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التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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