Test Price
2,800 AED✅ Home Collection Available
STX11 Gene Hemophagocytic Lymphohistiocytosis Type 4 (FHL4) Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
🔬Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
🚑Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
📞Clinical Guidance: Telephonic post-test clinical guidance in result interpretation by certified genetic counselors.
💰Insurance: Direct billing verification via WhatsApp +971 54 548 8731 — we coordinate with your network.
Test Overview & Methodology
The STX11 Gene NGS Test identifies pathogenic mutations in the STX11 gene responsible for Familial Hemophagocytic Lymphohistiocytosis Type 4 (FHL4), a rare, life-threatening immune dysregulation disorder. This genetic analysis provides definitive molecular diagnosis to guide therapy and evaluate at-risk family members.
| Feature | Our STX11 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) – full gene coverage, including deep intronic regions | Sanger sequencing of selected exons only |
| Diagnostic Precision | Detects >99.5% of pathogenic variants; copy number variations analyzed | Limited to known hotspots, may miss large deletions/duplications |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks (often sent abroad) |
| Price (AED) | 2,800 | 1,800 – 2,500 (incomplete analysis) |
| Accreditation | ISO 9001:2015 & DHA-MOHAP Licensed Laboratory | Variable |
Physician Insight & Safety Protocols
A note from Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA: 9294403): As a genetics specialist, I recognize the profound implications of diagnosing a rare immune disorder such as FHL4. This NGS-based test offers definitive molecular evidence, yet a negative result does not exclude other HLH subtypes. Comprehensive genetic counseling is imperative for accurate family risk stratification and informed clinical decisions.
All genetic findings must be correlated with complete immunological phenotyping and clinical presentation. Treatment planning requires a multidisciplinary hemato-immunology team.
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. Immunosuppressive therapy, including corticosteroids or etoposide, should not be altered based on genetic test results alone.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals who have received allogeneic hematopoietic stem cell transplantation within the last 3 months; donor DNA may confound results. This test is not intended for prenatal diagnosis without explicit pre-test genetic counseling in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Emergency Red Flags: If you or your child experiences persistent fever >38.5°C, severe hepatosplenomegaly, pancytopenia, or neurological symptoms, seek emergency care immediately. Do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the STX11 gene and its role in HLH type 4?
Snippet: The STX11 gene encodes syntaxin-11, essential for cytotoxic lymphocyte degranulation; mutations cause impaired killing of infected cells, triggering hyperinflammation. This defect underlies familial hemophagocytic lymphohistiocytosis type 4, a severe autosomal recessive condition. Genetic diagnosis enables precise immunomodulatory therapy and pre-transplant planning.
2. Who should consider this genetic test?
Snippet: Individuals presenting with early-onset fever, hepatosplenomegaly, pancytopenia, and consanguinity or a family history of HLH require STX11 analysis. This test confirms diagnosis in suspected primary HLH cases, carriers, and asymptomatic siblings in families with known mutations, enabling timely hematopoietic stem cell transplantation evaluation.
3. How is the test performed and what is the turnaround time?
Snippet: A simple blood draw or buccal swab is collected via VIP home phlebotomy; DNA is extracted and all STX11 coding exons are sequenced by NGS. Results, including a comprehensive clinical interpretation, are delivered within 3 to 4 weeks through a secure online portal with optional telephonic counseling.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework: All genetic testing and data handling at DNA Labs UAE strictly adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 certificate No. INT/EGQ/2509DA/3139 governs our quality management system. Results must be reviewed by a licensed hematologist or immunologist.
Clinical & Logistical Metadata
| Test Name | STX11 Gene Hemophagocytic Lymphohistiocytosis Type 4 (FHL4) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage Including Deep Intronic Regions |
| ICD-10-CM Code | D76.1 |
| LOINC Code | 94533-7 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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