Test Price
32,500 AEDโ Home Collection Available
Whole Genome De Novo Assembly and Annotation (Illumina) in UAE
Executive Summary & Core Metrics
99.9% diagnostic sensitivity โ This de novo genome assembly utilises Illuminaโs advanced NGS platform to construct a complete diploid blueprint from a simple blood sample. Our VIP mobile phlebotomy & temperature-controlled cold-chain home collection is available daily from 8 AM to 11 PM, with specimens processed at our ISO 9001:2015 certified laboratory. Results include telephonic clinical guidance by our Consultant Medical Genetics team. Direct insurance billing verification is available via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This comprehensive genomic service generates a fully assembled diploid genome map, enabling detection of structural variants, novel insertions, and regulatory elements invisible to standard arrays or exomes. The process employs Illumina HiSeq X sequencing with long-read gap filling and computational de novo assembly, followed by comprehensive annotation covering gene models, regulatory elements, and epigenetic marks.
| Feature | Our Test (De Novo Assembly) | Standard Genotyping Array |
|---|---|---|
| Methodology | Illumina HiSeq X, long-read gap filling, de novo assembly | Microarray SNP detection |
| Precision & Coverage | 99.9% base accuracy, complete diploid genome coverage | >99% SNP concordance but only 1โ2% genome coverage |
| Turnaround Time | 8 weeks | 3โ4 weeks |
| Annotation | Comprehensive gene models, regulatory elements, epigenetic marks | Basic SNP-based annotation, no structural insight |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403)
โDe novo genome assembly offers an unprecedented depth of genetic information, enabling precise risk stratification and personalised preventive strategies. However, all findings must be interpreted within the context of your personal and family history. No genomic report alone constitutes a clinical diagnosis.โ
Advisory: Medication Continuity
Do not discontinue or alter any prescribed medication without prior consultation with your managing physician. Genomic results may inform future therapy adjustments but must never replace current treatment decisions.
Safety Exclusion Criteria & Emergency Red Flags
- Not recommended for individuals currently receiving active chemotherapy or radiotherapy, as results may be confounded by treatment-related genetic damage.
- Pregnancy: must be accompanied by explicit pre-test genetic counseling and written informed consent.
- Minors (under 18): require written legal guardian consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ๐จ Emergency Red Flag: If your report identifies a pathogenic variant in a high-penetrance cancer gene (e.g., BRCA1, TP53, MLH1), you must seek immediate consultation with a specialised oncologist. Do not attempt self-interpretation of actionable mutations.
Patient FAQ & Clinical Guidance
1. What is the clinical value of whole genome de novo assembly?
Whole genome de novo assembly provides the most complete map of your DNA, capturing every structural variant, repetitive region, and novel sequence missed by standard genotyping arrays or exome sequencing. This enables precise anti-aging interventions, risk stratification for complex diseases, and discovery of personal pharmacogenomic variants.
2. How long does it take and how secure are my genetic data?
Your results are delivered within 8 weeks via a secure, encrypted portal fully compliant with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Samples are de-identified using a double-coding system immediately upon arrival, and all genomic data is stored in UAE-based ISO-certified servers with zero international transfer without explicit consent.
3. Is this covered by UAE health insurance?
Coverage depends on your plan, but we provide free direct billing verification via WhatsApp (+971545488731) and assist with prior authorization documentation for comprehensive genomic screening. Many premium policies now include whole genome sequencing โ simply send a photo of your insurance card to our team for an immediate eligibility check.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic data is encrypted, stored locally, and never shared without explicit consent.
Clinical & Logistical Metadata
| Test Name | Whole Genome De Novo Assembly and Annotation (Illumina) |
| Price (AED) | 32,500 |
| Turnaround Time | 8 weeks |
| Sample Type / Matrix | Peripheral whole blood (3 mL in EDTA tube) |
| Methodology Used | Illumina HiSeq X paired-end sequencing, de novo assembly with long-read gap filling, comprehensive annotation pipeline |
| ICD-10-CM Code | Z13.89 (Encounter for screening for other disorder) |
| LOINC Code | 83502-8 (Whole genome sequencing in blood or tissue by NGS) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians