Test Price
2,800 AED✅ Home Collection Available
ZNF423 Gene Nephronophthisis Type 14 NGS Genetic Test | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Post‑Test Telephonic Clinical Guidance for result interpretation and next‑step planning.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ZNF423 Nephronophthisis Type 14 NGS Test identifies pathogenic variants in the ZNF423 gene using next‑generation sequencing, enabling precise diagnosis of this rare ciliopathy‑related kidney disorder. This comprehensive analysis detects single nucleotide variants, small insertions and deletions, and copy number variations across the entire coding region with high confidence.
| Feature | Our Test (NGS) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | Full gene coverage + copy number variants | Targeted hot‑spot mutations only |
| Methodology | Next‑Generation Sequencing (Illumina®) with Sanger confirmation | Capillary electrophoresis (Sanger) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Clinical Reporting | ACMG/ClinVar‑guided interpretation + genetic counseling note | Basic variant list without integrated counseling |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I consider the ZNF423 gene test an essential diagnostic tool for patients presenting with unexplained cystic kidney disease, chronic renal insufficiency, or a family history consistent with nephronophthisis. The NGS platform provides the genomic breadth needed to detect elusive pathogenic variants that Sanger sequencing would miss. However, genetic test results must always be interpreted alongside renal ultrasound findings, urinalysis, and serum creatinine trends. A thorough family pedigree spanning at least three generations is equally critical for accurate risk assessment and cascade screening of at‑relatives.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
⚠️ Medication Advisory
Do not discontinue any prescribed medication (e.g., antihypertensives, immunosuppressants, diuretics, or renin‑angiotensin system inhibitors) without consulting your treating physician. Genetic findings do not alter acute pharmacological management and require integration with clinical nephrology assessment.
🛑 Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria (Home Collection): Active febrile illness, known bleeding diathesis (e.g., hemophilia, INR >2.0), or inability to follow instructions without a caregiver present during the phlebotomy visit.
- Emergency Red Flags: If you experience sudden flank pain, gross hematuria, oliguria, or signs of acute renal failure (nausea, confusion, peripheral edema), seek immediate emergency care and inform the treating physician about your pending genetic test.
Patient FAQ & Clinical Guidance
1. What is the ZNF423 genetic test and what condition does it diagnose?
This NGS‑based genetic test detects disease‑causing mutations in the ZNF423 gene to diagnose nephronophthisis type 14, a rare autosomal recessive ciliopathy that leads to progressive cystic kidney disease and end‑stage renal failure typically before adulthood. Early molecular diagnosis enables proactive nephrology monitoring and family planning.
2. How is the sample collected at home?
Our DHA‑licensed phlebotomist performs a standard venipuncture for peripheral blood collection into EDTA tubes, or a finger‑prick for dried blood spot sampling. All samples are transported under temperature‑controlled cold‑chain conditions directly to our ISO‑accredited laboratory. The service is available daily from 8 AM to 11 PM.
3. When will I receive my results and who interprets them?
Results are delivered within 3–4 weeks from sample receipt. A comprehensive clinical report is prepared by our Consultant Medical Genetics specialist, including variant classification per ACMG guidelines, correlation with clinical phenotypes, and a referral recommendation to a nephrologist when appropriate. A complimentary telephonic guidance session is provided to discuss findings.
4. Does a positive result mean I will definitely develop kidney failure?
No. A pathogenic ZNF423 variant indicates a genetic predisposition, but clinical expression varies widely due to modifier genes, environmental factors, and lifestyle influences. Penetrance is high but not absolute. Your result must be interpreted alongside renal imaging, biochemical panels, and detailed family history. Genetic counseling is an integral part of the testing process.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the highest standards of data protection and clinical governance in accordance with UAE federal legislation. All genetic test results are handled as highly confidential health data.
- Data Protection: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) ensuring your genetic information is collected, processed, and stored with explicit consent and robust encryption.
- Health Information Governance: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for all digital health records, telephonic consultations, and electronic reporting.
- Clinical Safety & Consent: All phlebotomy procedures and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability, guaranteeing your safety and legal rights throughout the testing journey.
Clinical & Logistical Metadata
| Test Name | ZNF423 Gene Nephronophthisis Type 14 NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral blood (EDTA) or Saliva / Buccal swab |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina® platform with Sanger confirmation |
| ICD-10-CM Code | Q61.5 (Nephronophthisis / Medullary cystic kidney disease) |
| LOINC Code | 81201-3 (Gene mutations found in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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