Test Price
2,800 AED✅ Home Collection Available
ZFR Gene SPG71 Genetic Test in UAE | 2800 AED | DHA-Licensed Laboratory
Executive Summary & Core Metrics
At DNA Labs UAE, we offer the UAE’s only ISO-certified Next-Generation Sequencing (NGS) assay for the ZFR gene associated with Hereditary Spastic Paraplegia SPG71. This life-changing genetic analysis delivers 99.9% diagnostic sensitivity, empowering accurate clinical diagnosis, family planning, and personalized management under the strict oversight of DHA-licensed geneticists. Price: 2800 AED inclusive of VIP mobile phlebotomy and cold-chain home collection (8 AM–11 PM), rapid 3–4 week turnaround, and direct insurance billing verification via WhatsApp.
Test Overview & Methodology
This comprehensive genetic test examines the ZFR gene through advanced Next-Generation Sequencing (NGS) to detect pathogenic variants responsible for hereditary spastic paraplegia type 71 (SPG71). Ideal for patients with progressive lower limb spasticity, gait disturbances, or a family history of SPG, the test provides definitive molecular confirmation, aids in prognosis, and guides targeted therapies.
| Feature | Our Test (DNA Labs UAE) | Standard Genetic Screening |
|---|---|---|
| Methodology | NGS (Illumina NovaSeq X Plus) with Sanger confirmation of pathogenic variants | Often limited to targeted genotyping or single exon sequencing |
| Gene Coverage | 100% coding exons + intron-exon boundaries, minimum 1000x depth | Partial coverage; may miss deep intronic or regulatory variants |
| Turnaround Time | 3–4 weeks | Often 6–8 weeks |
| Pre/Post-Test Support | Mandatory DHA-licensed genetic counseling & physician telephonic guidance | May lack integrated genetic counseling |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Geneticist, I emphasize that a positive ZFR mutation result requires careful clinical correlation—this genetic test does not stand alone as a diagnosis. I encourage every patient to undergo pre‑test counseling so you fully understand the implications for yourself and your family. Your journey is supported by a multidisciplinary team dedicated to translating these complex results into a clear, actionable care plan.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA ID: 9294403
Medication Advisory
⚠️ Do not discontinue any prescribed medication (e.g., baclofen, tizanidine) without consulting your treating physician. Abrupt changes may worsen spasticity or cause serious adverse effects.
Exclusion Criteria & Pre-Test Preparation
Safety & Exclusion Criteria
- Exclusion: Acute febrile illness, recent blood transfusion (within 4 weeks), or inability to provide informed consent. Pregnancy – consult genetic counselor before testing.
- ER Red Flags: Sudden loss of ambulation, acute urinary retention, or rapidly progressing spasticity requiring immediate neurological evaluation. Go to the nearest emergency department if these occur.
- Pre-Test Preparation: A mandatory genetic counseling session to document clinical history and construct a family pedigree is required. Samples: whole blood (3–5 mL EDTA tube), extracted DNA, or a single blood drop on an FTA card. No fasting necessary. If taking anticoagulants, please inform the phlebotomist.
Patient FAQ & Clinical Guidance
1. What is the ZFR gene and its role in SPG71?
The ZFR gene provides instructions for a zinc finger RNA-binding protein critical in neuronal development, and pathogenic variants in this gene cause hereditary spastic paraplegia type 71 (SPG71), typically presenting with progressive lower limb stiffness and gait difficulties beginning in childhood or early adulthood. Our full‑gene NGS test identifies mutations across all coding regions to confirm the molecular diagnosis.
2. How accurate is this test, and what does 99.9% sensitivity mean?
Our ISO‑certified NGS workflow achieves diagnostic sensitivity of 99.9% for detecting single nucleotide variants and small insertions/deletions within the ZFR gene, meaning that if a pathogenic mutation is present, the test will correctly identify it in virtually all cases.
3. What are the turnaround time and sample requirements?
Once our laboratory receives your specimen, the final report is delivered within 3 to 4 weeks. We accept a simple blood draw (whole blood in EDTA), extracted DNA, or a single drop of blood on an FTA card—offering flexible, pain‑free collection at your home through our VIP mobile phlebotomy service.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Security: This test strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted, stored securely, and accessed only by authorized personnel. Clinical reporting follows DHA guidelines for genetic testing, ensuring full transparency and confidentiality.
Clinical Safety & Consent: Genetic counseling and informed consent are mandatory under Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patients understand the scope, implications, and limitations of testing.
Clinical & Logistical Metadata
| Test Name | ZFR Gene Full Gene Sequencing (Hereditary Spastic Paraplegia SPG71) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM–11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina NovaSeq X Plus with Sanger confirmation |
| ICD-10-CM Code | G11.4, Z13.79, Z15.89 |
| LOINC Code | 98430-2 |
| DHA Facility License & Laboratory Address Invariants | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians