Test Price
2,800 AED✅ Home Collection Available
ZEB2 Gene Hirschsprung Disease Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين ZEB2 لمرض هيرشسبرونغ بتقنية التسلسل الجيني (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ضمان دقة بنسبة 99.9%: حساسية تشخيصية معتمدة عبر مختبر معتمد آيزو 9001:2015. Our ISO-certified processing ensures 99.9% diagnostic sensitivity. Home Collection: Paid hospital-grade home collection via ISO-certified cold-chain logistics and VIP mobile phlebotomy service (8 AM – 11 PM). Clinical Guidance: Complimentary telephonic post‑test clinical guidance by a DHA‑licensed genetic counsellor. Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview
This next‑generation sequencing (NGS) test analyses the entire coding region of the ZEB2 gene to detect pathogenic variants implicated in Hirschsprung disease and related syndromes. يوفر هذا التحليل معلومات وراثية دقيقة لتوجيه التشخيص والعلاج الجراحي للأطفال المصابين.
| Feature | Our NGS Test | Standard Sanger Sequencing |
|---|---|---|
| Methodology | Next‑Generation Sequencing (whole gene) | Targeted single‑exon analysis |
| Turnaround Time | 3 – 4 weeks | 4 – 6 weeks |
| Diagnostic Sensitivity | >99.9% | ~95% |
| Sample Types | Whole Blood, Extracted DNA, Dried Blood FTA Card | Whole Blood only |
Physician Insight & Safety Protocol
“As a neonatologist caring for newborns with congenital gut disorders, I know the uncertainty families face when Hirschsprung disease is suspected. This NGS test provides crucial genetic confirmation, but it must be weighed alongside clinical examination and radiology findings. A negative result does not completely exclude the condition, and a positive one should guide timely surgical planning in consultation with a paediatric surgeon.”
— Dr. PRABHAKAR REDDY, DHA Specialist Neonatologist (Licence: 61713011)
⚠ Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Not intended for asymptomatic adults without relevant family history; pre‑test genetic counselling is mandatory.
- Exclusion: Inadequate sample quality (haemolysed blood, low DNA yield) may require recollect.
- Red Flag: Acute onset of bilious vomiting, progressive abdominal distension, or absent bowel sounds in an infant – proceed directly to emergency care; do not wait for genetic results.
- Red Flag: Signs of toxic megacolon (fever, severe tenderness, sepsis) require immediate surgical evaluation.
Patient FAQ & Clinical Guidance
1. What is the ZEB2 Gene Hirschsprung Disease Genetic Test?
A genetic NGS test that identifies ZEB2 gene mutations causing Hirschsprung disease in affected individuals. This comprehensive analysis scans the entire ZEB2 coding sequence, detecting point mutations, small insertions/deletions, and copy number variants. It is recommended when clinical features such as chronic constipation, abdominal distension, and delayed meconium passage suggest Hirschsprung disease or Mowat‑Wilson syndrome.
اختبار جيني بتقنية NGS يحدد طفرات جين ZEB2 المسببة لمرض هيرشسبرونغ، يُجرى على عينة دم أو حمض نووي، ويُستخدم لتوجيه التدخل الجراحي والاستشارة الوراثية.
2. Who should consider this test?
Infants and children exhibiting signs of Hirschsprung disease such as chronic constipation and abdominal swelling. Additional candidates include neonates with delayed passage of meconium, children with unexplained intestinal obstruction, or those with a known family history of ZEB2‑related syndromes. A referral from a paediatric gastroenterologist, surgeon, or clinical geneticist ensures the is medically appropriate.
الرضع والأطفال الذين تظهر عليهم علامات مرض هيرشسبرونغ مثل الإمساك المزمن وانتفاخ البطن، أو حديثو الولادة المتأخرون في تمرير العِقي، يجب مناقشة الفحص مع استشاري وراثي.
3. What do the results mean?
Positive result confirms ZEB2 mutation linked to Hirschsprung disease, aiding surgical decisions and family counselling. A confirmed pathogenic variant establishes the molecular diagnosis and allows targeted surgical management and cascade testing in at‑risk relatives. A negative result reduces but does not eliminate the possibility of Hirschsprung disease, as other genes or non‑genetic factors may be involved.
النتيجة الإيجابية تؤكد وجود طفرة جين ZEB2 المرتبطة بمرض هيرشسبرونغ، مما يساعد في التخطيط الجراحي واستشارات العائلة حول فحص الأقارب.
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