Test Price
2,800 AED✅ Home Collection Available
ZC4H2 Gene Wieacker-Wolff Syndrome Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic accuracy of 99.9% via ISO 9001:2015 certified laboratory processing.
- VIP mobile phlebotomy home collection with temperature-controlled cold-chain transport, available daily 8 AM to 11 PM.
- Post-test telephonic genetic counseling to interpret results and provide guidance.
- Direct insurance verification via WhatsApp: +971 54 548 8731
Test Overview & Methodology
This state-of-the-art next-generation sequencing (NGS) test decodes the entire ZC4H2 gene to identify mutations causing Wieacker-Wolff syndrome – a rare X-linked neurodevelopmental disorder marked by congenital contractures, intellectual disability, and motor neuron involvement. Precise diagnosis enables tailored early intervention and genetic counselling.
| Feature | DNA Labs UAE Test | Closest Alternative |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) – full gene coverage | Sanger sequencing (limited to known hotspots) |
| Diagnostic Sensitivity | ≥ 99.9% for coding & splice‑site variants | ~85% for targeted panels |
| Turnaround Time | 3 – 4 weeks (expedited available) | 4 – 6 weeks |
| Accreditation | ISO 9001:2015, DHA‑licensed facility 1143 | Variable |
Physician Insight & Safety Protocols
Advisory on Test Preparation & Safety
- No fasting or medication changes are required before sample collection.
- Informed consent must be provided; for minors under 18 years, written parental/guardian consent is mandatory per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Genetic test results are diagnostic, not therapeutic directives. Do not discontinue or adjust any prescribed medication without consulting your treating physician.
Exclusion Criteria for Sample Collection
- Patients with an active, untreated infection or acute neurological decompensation should postpone sample collection.
- If the individual has received a blood transfusion within the last 2 weeks, please inform the phlebotomist; a fresh whole‑blood sample may be required.
- Seek immediate emergency care if the patient experiences sudden muscle stiffness with breathing difficulties, severe swallowing problems, or loss of consciousness.
Patient FAQ & Clinical Guidance
1. What exactly does the ZC4H2 genetic test detect, and why is NGS used?
This test locates pathogenic variants in the ZC4H2 gene that cause Wieacker-Wolff syndrome using comprehensive next‑generation sequencing. NGS enables simultaneous reading of all coding regions and flanking splice sites, capturing rare small deletions, missense, and nonsense mutations with unmatched sensitivity.
2. Can this test be performed on a blood spot card (FTA card) or extracted DNA?
Yes, we accept whole blood, FTA card dried blood spots, or pre‑extracted genomic DNA. A small volume of blood (1–2 drops) is sufficient on an FTA card, which stabilises DNA at room temperature. Our ISO‑certified cold‑chain home collection team will handle all sample types with strict chain‑of‑custody documentation.
3. How should I prepare for the test, and is a genetic counselling session mandatory?
A genetic counselling session is strongly recommended to interpret family history and explain possible X‑linked inheritance before testing. No fasting or medication change is required. Our DHA‑licensed team will coordinate a 30‑minute tele‑counselling appointment to draw a family pedigree and discuss informed consent.
UAE Regulatory & Data Privacy Adherence
This service strictly complies with UAE healthcare regulations:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – All genetic information is encrypted and stored in accordance with UAE PDPL, with mandatory breach notification.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – Electronic health data handling follows strict security and interoperability standards.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – Genetic tests require a physician’s order and documented informed consent; results are protected as sensitive health data.
- DHA Facility License 1143 & ISO 9001:2015 – Our laboratory and logistics meet international quality and safety benchmarks.
Clinical & Logistical Metadata
| Test Name | ZC4H2 Gene Sequencing for Wieacker-Wolff Syndrome |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 weeks (expedited available) |
| Sample Type / Matrix | Whole Blood (Peripheral), FTA Card Dried Blood Spot, or Extracted Genomic DNA — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) — Full Gene Coverage |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 79255-8 |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
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