Test Price
2,800 AED✅ Home Collection Available
VIPAS39 Gene NGS Test – Arthrogryposis, Renal Dysfunction & Cholestasis Type 2 | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- ✓ Diagnostic Accuracy: 99.9% analytical sensitivity via ISO 9001:2015‑certified Next‑Generation Sequencing at our DHA‑licensed genetic facility.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection – available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Complimentary telephonic post‑test session with a genetic counsellor to interpret results and plan next steps.
- ✓ Insurance & Billing: Direct insurance verification via WhatsApp at +971 54 548 8731. DHA Facility License No. 1143.
Test Overview & Methodology
The VIPAS39 gene next‑generation sequencing (NGS) test interrogates the entire coding region to detect pathogenic variants responsible for Arthrogryposis, Renal dysfunction, and Cholestasis (ARC) syndrome type 2 – a rare autosomal recessive disorder with multi‑system involvement. This targeted analysis provides rapid, cost‑effective confirmation when clinical suspicion is high, enabling timely multidisciplinary intervention.
| Feature | Our VIPAS39 NGS Test | Whole Exome Sequencing (Alternative) |
|---|---|---|
| Precision | Targeted deep sequencing of VIPAS39 – 99.9% sensitivity for coding variants | Broader coverage but may miss deep intronic or low‑coverage regions in VIPAS39 |
| Methodology | NGS with copy‑number variant analysis (LC‑MS/MS compatible validation) | Standard exome capture; often requires reflex targeted confirmation |
| Turnaround | 3–4 weeks with expedited genetic counselling report | 4–8 weeks; interpretation may be less disease‑focused |
Physician Insight & Safety Protocols
“The VIPAS39 NGS test offers a definitive molecular diagnosis for ARC syndrome type 2, which is critical for guiding renal and hepatic management in affected infants. However, results must always be correlated with clinical findings including renal ultrasound and liver function tests. I strongly advise all families to engage in pre‑ and post‑test genetic counselling to fully understand implications for recurrence risk and long‑term prognosis.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue any prescribed medication (ursodeoxycholic acid, antihistamines, renal support) without consulting your physician. This test is for diagnostic clarification, not therapeutic replacement.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Individuals unable to provide a 3‑generation pedigree during genetic counselling, or those unwilling to sign informed consent as per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Seek emergency care immediately if: Acute jaundice with severe pruritus, oliguria/anuria (≤0.5 mL/kg/h in children), or sudden worsening of joint contractures with dehydration.
Patient FAQ & Clinical Guidance
1. What is the VIPAS39 gene test and why is it ordered for an infant with contractures and jaundice?
The VIPAS39 NGS test identifies disease‑causing mutations in the VIPAS39 gene, confirming a diagnosis of ARC syndrome type 2 when a child presents with arthrogryposis, renal dysfunction, and cholestasis. Early genetic confirmation allows clinicians to initiate supportive renal and hepatic care and provide accurate recurrence risk counselling for the family.
2. How should I prepare my child for the blood draw or buccal swab at home?
No fasting or medication changes are required. Simply ensure the child is well‑hydrated and the home collection environment is calm to minimise distress during the procedure. Our trained phlebotomist will use age‑appropriate techniques for a comfortable experience.
3. Will my insurance cover the 2,800 AED cost and does the report comply with UAE privacy laws?
Our team verifies coverage directly through WhatsApp. All genetic reports are fully compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019, ensuring your data remains secure within DHA‑licensed infrastructure.
UAE Regulatory & Data Privacy Adherence
All genetic testing and data handling at DNA Labs UAE strictly follow Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genomic data is encrypted, access‑controlled, and never shared without explicit written consent.
Clinical & Logistical Metadata
| Test Name | VIPAS39 Gene NGS Test – Arthrogryposis, Renal Dysfunction & Cholestasis Type 2 |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood or buccal swab (VIP Mobile Phlebotomy & Cold‑Chain Home Collection available daily 8 AM – 11 PM) |
| Methodology Used | Next‑Generation Sequencing (NGS) with copy‑number variant analysis |
| ICD-10-CM Code | Q87.8 (Arthrogryposis, Renal dysfunction, and Cholestasis syndrome type 2) |
| LOINC Code | 81260-5 (Genetic analysis of a specified gene in blood or tissue by molecular genetics method) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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