Test Price
2,800 AED✅ Home Collection Available
UNC45B Gene Cataract Type 43 Genetic Test in UAE | 2 800 AED
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity – ISO‑Accredited NGS Workflow
- ✓ Premium Logistics: Hospital‑Grade Home Collection with ISO‑certified cold‑chain transport (blood, FTA card, or extracted DNA).
- ✓ Clinical Guidance: Telephonic post‑test interpretation by a DHA‑licensed genetic counsellor.
- ✓ Insurance: Direct billing verification via WhatsApp +971 54 548 8731
Please note: This test requires standard peripheral blood or buccal swab. Home phlebotomy is available daily from 8 AM to 11 PM via temperature‑controlled courier.
Test Overview & Methodology
This targeted NGS assay screens the complete coding region of the UNC45B gene for pathogenic variants associated with autosomal dominant congenital cataract type 43.
| Feature | Our UNC45B NGS Test | Closest Alternative (Gene Panel) |
|---|---|---|
| Precision | Full UNC45B sequencing with MLPA backup; 99.9% sensitivity | Partial coverage; may miss deep intronic variants |
| Method | Targeted NGS + Sanger confirmation (DHA‑approved protocol) | Sanger only for a few known hotspots |
| Turnaround Time | 18 – 21 working days | 4 – 6 weeks |
| Report | Clinically annotated with ACMG classification and genetic counselling notes | Technical variant list only |
Physician Insight & Safety Protocols
“A positive UNC45B result can confirm a genetic diagnosis, but cataract management remains multi‑factorial. I always correlate molecular findings with a detailed ophthalmic exam and family history. Please never stop prescribed therapy without a full clinical review.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue any prescribed medication, including ocular hypotensives or anticoagulants, without explicit consultation with your treating ophthalmologist or genetic counsellor. Abrupt changes may jeopardize ocular or systemic health. This warning is issued in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Unwillingness to provide informed consent for genetic testing or data privacy (UAE PDPL mandatory).
- Exclusion: Acute febrile illness at time of sample collection – reschedule 72 h after fever resolution.
- Exclusion: Indwelling central line without clear venous access – alternative capillary FTA card collection may be used.
- Emergency Red Flags: Sudden vision loss, severe eye pain, or acute onset of flashes/floaters – proceed directly to ER; do not wait for test results.
- Red Flag: Known allergy to latex (alt. syringe collection available).
Patient FAQ & Clinical Guidance
1. How accurate is the UNC45B genetic test for congenital cataract type 43?
The 99.9% diagnostic sensitivity is achieved through dual‑platform NGS and Sanger confirmation, directly detecting all clinically significant UNC45B variants. False positives are ruled out by secondary orthogonal verification, and results are interpreted according to ACMG guidelines.
2. Can children or asymptomatic family members take this test in the UAE?
Yes, under UAE PDPL and Federal Law No. 2 of 2019 concerning Use of ICT in Health, minor testing requires dual parental consent and a pre‑genetic counselling session to document pedigree and informed consent. Asymptomatic carrier screening of siblings is allowed when a pathogenic variant is already identified in the family.
3. What happens after I receive my genetic result?
You will receive a tele‑appointment with a DHA‑licensed genetic counsellor who explains the clinical significance, recurrence risk, and personalised management steps within 48 hours. The report includes actionable recommendations for ophthalmological follow‑up and family planning.
UAE Regulatory & Data Privacy Adherence
- ✅ DHA/MOHAP Compliant – All testing performed under DHA Facility License No. 1143.
- 🔒 Data Privacy – Strict adherence to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- 🏥 Health Data Protection – Complies with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- ⚕️ Medical Liability – Patient safety and consent governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- 🏅 ISO 9001:2015 – Certified (Certificate INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | UNC45B Gene Cataract Type 43 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 18 – 21 working days |
| Sample Type / Matrix | Peripheral whole blood, FTA card, or extracted DNA |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | Q12.0 |
| LOINC Code | 101188-5 |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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