Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3 to 4 Weeks
UGT1A1 Gene Crigler-Najjar Syndrome Type 1 Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced NGS-based test analyzes the entire UGT1A1 gene to detect pathogenic variants causing Crigler-Najjar syndrome type 1, a severe unconjugated hyperbilirubinemia disorder present from birth. The test delivers definitive molecular diagnosis, guiding liver transplantation decisions and enabling informed family genetic counseling, with results available in 3 to 4 weeks.
| Feature | Our UGT1A1 NGS Comprehensive Test | Biochemical Enzyme Assay (Closest Alternative) |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) โ Full Gene | Hepatic UGT1A1 Enzyme Activity Measurement |
| Turnaround Time | 3 to 4 Weeks | 7-10 Days (but invasive liver biopsy required) |
| Diagnostic Sensitivity | 99.9% for known pathogenic variants | Limited; cannot identify specific mutations |
| Coverage | All exons, splice sites, and regulatory regions | Indirect functional assessment; no genetic detail |
Physician Insight & Safety Protocols
โAs a Consultant Medical Genetics specialist, I recognize the profound implications a UGT1A1 diagnosis carries for families. This NGS-based test provides definitive molecular confirmation, enabling timely intervention and informed family planning. All results must be contextualized within the full clinical history and discussed with a multidisciplinary care team.โ
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory
Do not discontinue or alter prescribed medications without consulting your treating physician.
Safety Exclusion Criteria & Emergency Red Flags
- Inability to provide informed consent (or parental consent for minors as per UAE regulations).
- Patients under 18 without a legal guardian's explicit consent.
- Lack of clinical indication or referral from a qualified genetic counsellor.
- ER Red Flags: Signs of acute bilirubin encephalopathy โ severe jaundice with lethargy, poor feeding, high-pitched cry, arching of back โ seek emergency care immediately.
Patient FAQ & Clinical Guidance
1. What is UGT1A1 Crigler-Najjar syndrome type 1, and how does the NGS test detect it?
The UGT1A1 gene Crigler-Najjar syndrome type 1 test uses next-generation sequencing to identify pathogenic variants causing severe unconjugated hyperbilirubinemia from birth, enabling precise molecular diagnosis and guiding clinical management.
2. How do I prepare for the test, and what samples are needed?
A blood sample (venous blood or a dried blood spot on an FTA card) is required, along with a mandatory pre-genetic counseling session to document family history of UGT1A1-related jaundice.
3. What do the results mean, and what is the turnaround time?
Results report specific UGT1A1 mutations; a pathogenic or likely pathogenic variant confirms the diagnosis. The standard turnaround time is 3 to 4 weeks from sample receipt at the laboratory.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection Framework
All genetic testing and patient data handling at DNA Labs UAE strictly comply with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Federal Decree-Law No. 4 of 2016 on Medical Liability for clinical safety and informed consent.
Our laboratory is fully accredited by the Dubai Health Authority (DHA) and operates under ISO 9001:2015 certified processes (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | UGT1A1 Gene Crigler-Najjar Syndrome Type 1 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Venous Blood or FTA Card (Dried Blood Spot) |
| Methodology Used | Next Generation Sequencing (NGS) โ Full Gene Analysis |
| ICD-10-CM Code | E80.5 |
| LOINC Code | 48807-8 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["Pre-genetic counseling session required", "Document family history of UGT1A1-related jaundice"]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians