Test Price
2,800 AED✅ Home Collection Available
TUSC3 Gene Mental Retardation, Autosomal Recessive Type 7 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity for TUSC3 pathogenic variants via ISO 9001:2015 accredited Next Generation Sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation with a DHA-licensed genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TUSC3 NGS test screens the entire coding region of the tumor suppressor candidate 3 gene using Next Generation Sequencing to identify causative variants for autosomal recessive mental retardation type 7. This analysis is critical for differential diagnosis of early childhood neurodevelopmental delay and family risk assessment.
| Feature | Our Test (NGS) | Alternative (Traditional Sanger) |
|---|---|---|
| Precision | >99.9% sensitivity for SNVs/indels | ~95% targeted exon analysis |
| Method | High-throughput Illumina NovaSeq X Plus | Capillary electrophoresis, single amplicon |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks per gene |
| Coverage | Full gene + 20bp flanking introns | Single exon at a time |
| UAE Regulatory | DHA & ISO 9001:2015 | May lack local accreditation |
Physician Insight & Safety Protocols
"As a DHA-licensed consultant medical geneticist, I emphasize that a TUSC3 pathogenic variant alone does not define a clinical outcome; thorough neurodevelopmental assessment and family genetic counselling are essential for accurate interpretation. Parents often feel anxious about an intellectual disability diagnosis, but early identification guides supportive therapies and reproductive options. Please share any developmental milestones concerns with your specialist to correlate with the molecular findings."
Advisory on Genetic Counseling
Genetic test results should always be interpreted in conjunction with a complete clinical evaluation and family history. A negative result does not rule out other genetic or non-genetic causes. Consult with your genetic counsellor before making any medical decisions based on this test.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Active febrile illness or acute infection – postpone collection until recovered.
- Recent blood transfusion or bone marrow transplant (within 8 weeks) may interfere with germline DNA analysis.
- If patient experiences new-onset seizures, loss of consciousness, or severe behavioural regression, seek emergency medical evaluation immediately rather than waiting for genetic results.
- For minors, valid consent from legal guardian is mandatory per Federal Decree-Law No. 4 of 2016 on Medical Liability; no testing without proper authorization.
Patient FAQ & Clinical Guidance
1. What does a positive TUSC3 result mean for my child’s future?
A positive result confirms a genetic cause for the observed developmental delay, enabling targeted early intervention therapies and informing recurrence risk in future pregnancies. However, the severity can vary, and regular follow-up with a neurologist and developmental paediatrician is crucial for optimal outcomes.
2. Why does the test take 3–4 weeks?
NGS sequencing requires library preparation, high-fidelity sequencing on Illumina platforms, bioinformatics alignment against reference genome GRCh38, and rigorous variant interpretation by clinical geneticists following ACMG guidelines, all under ISO-accredited quality management.
3. Is home sample collection safe and reliable?
Our certified phlebotomists use a vacuum-sealed cold-chain kit that maintains DNA integrity from collection to lab, validated to meet ISO 9001:2015 standards. The process is identical to hospital collection, minimizing pre-analytical errors. VIP Mobile Phlebotomy is available daily from 8 AM to 11 PM.
UAE Regulatory & Data Privacy Adherence
This laboratory service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. The facility holds DHA Facility License Number 1143 and is operated under ISO 9001:2015 quality management standards.
Clinical & Logistical Metadata
| Test Name | TUSC3 Gene Mental Retardation, Autosomal Recessive Type 7 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 21–28 Days (3–4 Weeks) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily 8 AM – 11 PM |
| Methodology Used | Next Generation Sequencing (NGS) – Illumina NovaSeq X Plus |
| ICD-10-CM Code | F78.9, Z14.8, Z82.79 |
| LOINC Code | 94500-0 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | DNA Labs UAE – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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