Test Price
2,800 AED✅ Home Collection Available
TUBB4A Gene DYT4 Next‑Generation Sequencing Genetic Test in UAE
Executive Summary & Core Metrics
✔ Diagnostic Precision: 99.9% Analytical Sensitivity & 100% Exon Coverage via ISO‑Certified NGS
✔ Premium Home Collection: ISO‑Certified Cold‑Chain VIP Phlebotomy (8 AM–11 PM) – 2800 AED
✔ Clinical Guidance: Complimentary Post‑Test Tele‑Consultation with Genetic Counselor
✔ Insurance Assistance: Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The TUBB4A gene encodes beta‑tubulin‑4A; pathogenic mutations cause DYT4 dystonia, a rare autosomal dominant movement disorder presenting with progressive laryngeal and cervical dystonia. Our Next‑Generation Sequencing assay captures the complete coding exons and flanking splice sites, detecting single nucleotide variants, small insertions/deletions, and copy number changes, enabling definitive diagnosis and personalised multidisciplinary care.
| Feature | Our NGS Test (Precision Genomics) | Standard Sanger Sequencing |
|---|---|---|
| Target | Full TUBB4A coding exons ±10 bp intronic flanks | Selected hotspot regions only |
| Detection Rate | >99% of known pathogenic variants; includes CNV analysis | ~70%; limited to point mutations/indels |
| Turnaround Time | 3–4 Weeks (ISO 9001:2015 certified lab) | 6–8 Weeks |
| Clinical Report | ClinGen‑based variant classification with DHA‑approved geneticist review | Limited annotation; often requires secondary interpretation |
Physician Insight & Safety Protocols
“I am Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403). Genetic testing for TUBB4A‑related dystonia provides a definitive molecular diagnosis, but it must be correlated with a detailed neurological examination and family history. We strongly recommend pre‑ and post‑test genetic counselling to discuss inheritance risks and clinical management. Always continue prescribed medications unless directed otherwise by your treating physician.”
⚠ Medication Advisory
Clinically Important: Do not discontinue any prescribed muscle relaxants, anticholinergics, or botulinum toxin therapy without consulting your doctor.
⚠ Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; minors without legal guardian’s written consent.
- Exclusion: Recent hematopoietic stem cell transplantation (may cause somatic mosaicism).
- Red Flag – Seek Emergency Care: Sudden stridor, respiratory distress, or acute dystonic crisis with compromise of airway.
- Red Flag: Status dystonicus – continuous severe muscle spasms requiring hospitalisation.
If you experience any of these signs, call 998 for UAE Ambulance or proceed to the nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is the TUBB4A gene DYT4 NGS test and why is it done?
This test analyses the entire TUBB4A gene by Next‑Generation Sequencing to confirm the diagnosis of dystonia type 4 in adults presenting with progressive neck or voice spasms. It is recommended when clinical examination suggests a genetic dystonia syndrome, especially with a positive family history, to guide targeted therapy and family screening.
2. How is the sample collected and what can I expect during the home visit?
A DHA‑licensed phlebotomist will visit your home (8 AM–11 PM) using a cold‑chain validated kit; only 2–3 mL of whole blood is drawn, or a buccal swab if preferred. No fasting is required, and the collection takes less than 10 minutes with complete infection control.
3. Will my genetic data remain confidential under UAE law?
Absolutely; your genomic data is protected by Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and the Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All analysis is performed in an ISO 27001‑aligned bioinformatics environment, and results are shared only with the authorised ordering physician and the patient.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Privacy
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring the highest standards of genetic data privacy and security.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing the secure handling of electronic health records and genomic data.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – safeguarding patient consent and clinical safety during genetic testing.
- ISO 9001:2015 Certified Facility (Cert: INT/EGQ/2509DA/3139) – Scope: Clinical Genetic Testing.
- DHA Standard Nomenclature adherence; all methods validated against ACMG guidelines.
Emergency Contacts: UAE Ambulance 998 | Poison & Drug Info 800424 | Home Collection Scheduling: +971 54 548 8731
Clinical & Logistical Metadata
| Test Name | TUBB4A Gene DYT4 Next‑Generation Sequencing Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood or Buccal Swab |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD-10-CM Code | G24.1 |
| LOINC Code | 90553-4 |
| DHA Facility License & Lab Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians