Test Price
2,800 AED✅ Home Collection Available
TTC37 Gene Trichohepatoenteric Syndrome Type 1 Genetic Test in UAE | 2800 AED | DHA Approved
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM – 11 PM)
Clinical Guidance: Telephonic Post-Test Clinical Guidance with Board-Certified Medical Geneticist
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The TTC37 Gene Next-Generation Sequencing (NGS) test identifies pathogenic variants in the TTC37 gene causing Trichohepatoenteric syndrome type 1 (THES1), a rare multisystem disorder marked by intractable diarrhea, facial dysmorphism, woolly hair, and severe immunodeficiency. This definitive molecular diagnosis enables precise clinical management, family planning, and targeted therapeutic decisions.
| Comparison | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% analytical sensitivity (full-gene NGS) | Limited to known point mutations (Sanger) |
| Method | Next Generation Sequencing (NGS) – full coding region + splice sites | Targeted mutation analysis; may miss novel variants |
| Speed | TAT 3–4 Weeks | Often 6–8 Weeks due to stepwise testing |
Physician Insight & Safety Protocols
"From a genetic perspective, the TTC37 NGS test provides a definitive molecular diagnosis for THES1, allowing targeted surveillance for immunodeficiency and chronic enteropathy. However, results must always be interpreted in the context of a thorough clinical phenotype and family history—a negative result does not exclude other syndromic causes and should not replace multidisciplinary follow-up."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA: 9294403
Advisory & Medication Warning
Medication Warning:
Do not discontinue prescribed medication without consulting your doctor. This test is for diagnostic insight and does not replace active treatment or emergency intervention.
Safety Exclusion Criteria & Red Flags
- Exclusion: Recent blood transfusion (within 2 weeks) may compromise DNA integrity; repeat sample required.
- Exclusion: Acute severe infection or systemic inflammatory state can affect sample quality; testing should be postponed until resolved.
- ER Red Flag: Signs of severe dehydration (sunken eyes, dry mucous membranes, lethargy), significant gastrointestinal bleeding, or sepsis require immediate emergency evaluation.
- ER Red Flag: Acute respiratory distress or altered consciousness in a known immunodeficiency patient demands urgent care, irrespective of pending genetic results.
Patient FAQ & Clinical Guidance
1. What is the TTC37 gene test?
The TTC37 Genetic Test detects pathogenic mutations responsible for Trichohepatoenteric syndrome type 1 (THES1), which manifests as intractable diarrhea, woolly hair, facial dysmorphism, and severe immunodeficiency—providing a definitive genetic diagnosis to guide multidisciplinary care.
2. Is genetic counseling mandatory before the test?
Yes, a pre‑test genetic counseling session is required to draw a detailed pedigree chart and explain the implications of TTC37 gene mutations, ensuring fully informed consent in line with UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability and Federal Law No. 2 of 2019 concerning health data use.
3. How long does it take to get the result and who interprets it?
Our laboratory delivers TTC37 NGS results within 3 to 4 weeks; every report is reviewed by a board‑certified clinical geneticist (Dr. Lina Osama Zaki Quteineh, DHA: 9294403) and includes a telephonic post‑test guidance session upon request for clinical correlation.
UAE Regulatory & Data Privacy Adherence
This genetic service strictly complies with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree‑Law No. 4 of 2016 on Medical Liability (clinical safety and consent)
- Dubai Health Authority (DHA) regulatory standards for genetic testing
Processing is performed at DNA Labs UAE, a facility licensed by DHA (License No. 1143) and certified to ISO 9001:2015.
Clinical & Logistical Metadata
| Attribute | Value |
|---|---|
| Test Name | TTC37 Gene Sequencing (Trichohepatoenteric Syndrome Type 1) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) |
| Methodology Used | Next Generation Sequencing (NGS) – full coding region + splice sites |
| ICD-10-CM Code | Q87.8 (Other specified congenital malformation syndromes affecting multiple systems) |
| LOINC Code | 81373-8 (Trichohepatoenteric syndrome 1 gene analysis) |
| DHA Facility License & Address | DNA Labs UAE, License: 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians