Test Price
2,800 AEDโ Home Collection Available
TRPV3 Gene (Olmsted Syndrome) NGS Diagnostic Test in UAE | DNA Labs UAE
Executive Summary & Core Metrics
โ 99.9% Diagnostic Sensitivity โ ISO-Accredited Genetic NGS Processing
๐ฅ Premium Hospital-Grade Home Collection (Cold-Chain) & VIP Mobile Phlebotomy
๐ Telephonic Post-Test Clinical Guidance & Result Interpretation
๐ Direct Insurance Billing Verification via WhatsApp: +971 54 548 8731
Mandatory pre-test genetic counselling & pedigree chart completion required by UAE regulatory standards.
Test Overview & Methodology
The TRPV3 Gene Olmsted Syndrome Genetic Test is a comprehensive next-generation sequencing (NGS) analysis designed to identify pathogenic mutations in the TRPV3 gene, confirming a clinical diagnosis of Olmsted syndrome โ a rare, severe palmoplantar keratoderma with periorificial keratotic plaques. This test empowers dermatologists, clinical geneticists, and pediatricians to provide precise genetic counselling and personalized management plans for affected families.
Utilizing a full-gene NGS approach, this assay delivers complete coverage of all coding exons and flanking intronic regions, enabling the detection of single nucleotide variants, small insertions, and deletions with the highest sensitivity in the UAE.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Methodology | Comprehensive full-gene sequencing | Limited to known hot-spot exons |
| Diagnostic Yield | >99.9% for all TRPV3 variants | ~80% (misses novel or deep intronic mutations) |
| Turnaround Time | 3โ4 weeks | 4โ6 weeks |
| Price (AED) | 2,800 AED | Not disclosed / variable |
Physician Insight & Safety Protocols
Ms. Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403): โThis NGS test provides a definitive molecular confirmation for Olmsted syndrome, which is essential for accurate genetic counseling and long-term syndromic management. Clinicians must interpret the results within the full context of the patientโs cutaneous and systemic phenotype, and families deserve compassionate, multi-disciplinary guidance to navigate the treatment and genetic implications.โ
Clinical Advisory & Genetic Data Protection
โ ๏ธ Genetic Data Handling Notice
Do not discontinue prescribed medication without consulting your doctor. Genetic test results should never be used to independently alter treatment plans. All genomic data is processed under strict adherence to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Safety Exclusion Criteria & Emergency Red Flags
๐ Contraindications & Urgent Medical Review
- Inability to provide informed consent (or absence of legal guardian for minors, per UAE Federal Law on Medical Liability).
- Severe coagulopathy or active bleeding disorder for venipuncture โ alternatively, a DNA FTA card collection may be utilized.
- Confirmed pregnancy is not a contraindication, but consultation with a maternal-fetal medicine specialist is advised prior to testing.
- Seek emergency medical care if you experience sudden rapid progression of skin lesions, signs of systemic inflammation, or inability to eat/drink due to oral involvement.
Patient FAQ & Clinical Guidance
1. What is the TRPV3 Gene Olmsted Syndrome Genetic Test and why is it performed?
This advanced DNA test uses next-generation sequencing (NGS) to identify all clinically significant mutations in the TRPV3 gene, providing a definitive molecular diagnosis of Olmsted syndrome. It is indicated for patients presenting with severe palmoplantar keratoderma and periorificial keratotic plaques, enabling targeted therapy, genetic counselling, and family cascade screening.
2. How is the sample collected for this genetic test?
A peripheral whole blood sample, extracted DNA, or a single drop of blood on an FTA card is collected through our VIP hospital-grade mobile phlebotomy service. All specimens are transported using a temperature-controlled cold-chain logistics system to ensure genomic integrity from your home to our ISO-accredited laboratory.
3. What is the turnaround time and cost for this TRPV3 NGS test?
Results are typically available within 3 to 4 weeks. The total cost for the comprehensive analysis is 2,800 AED. DNA Labs UAE provides direct insurance billing verification via WhatsApp at +971 54 548 8731 to streamline your pre-authorization process.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Governance
DNA Labs UAE strictly adheres to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for the secure handling of all genetic and genomic data. Clinical safety and patient consent protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All genomic information is encrypted, stored in a secure UAE-based environment, and accessed solely by authorized clinical personnel for diagnostic purposes.
Clinical & Logistical Metadata
| Test Name | TRPV3 Gene (Olmsted Syndrome) NGS Diagnostic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood / Extracted DNA / FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | Q82.8 (Other specified congenital malformations of skin) |
| LOINC Code | 50398-7 (Hereditary cutaneous disorder gene targeted mutation analysis) |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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