Test Price
2,800 AED✅ Home Collection Available
TPI1 Gene Hemolytic Anemia due to Triosephosphate Isomerase Deficiency Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity – NGS sequencing, ISO 9001:2015 accredited processing.
- Premium Home Collection – Hospital‑grade cold‑chain phlebotomy & VIP mobile service (8 AM–11 PM).
- Telephonic Post‑Test Guidance – Clinical interpretation by a DHA‑licensed genetic counsellor.
- Insurance Direct Billing – WhatsApp verification at +971 54 548 8731.
Test Overview & Methodology
TPI1 NGS Test detects pathogenic variants in the TPI1 gene causing triosephosphate isomerase deficiency – a rare glycolytic enzymopathy leading to hemolytic anemia and neurodegeneration. This test supports definitive diagnosis, carrier detection, and prenatal planning with DHA-compliant reporting.
| Feature | Our NGS Test (DHA‑Licensed) | Standard Hemolytic Anemia Panel |
|---|---|---|
| Methodology | Next‑Generation Sequencing (full gene coverage ±20 bp flanking) | Targeted mutation analysis or Sanger sequencing (limited) |
| Clinical Sensitivity | >99.9% for SNVs, indels, CNVs | 60–80%, misses novel variants |
| Turnaround Time | 3–4 Weeks | 4–8 Weeks |
| Sample Flexibility | Whole blood, extracted DNA, or one drop on FTA card | Usually blood only |
| UAE Compliance | Federal Decree‑Law No. 45 of 2021 (PDPL) & Federal Law No. 2 of 2019 | May not meet genetic consent and data protection laws |
Physician Insight & Safety Protocols
“A positive TPI1 variant must be interpreted alongside clinical phenotype and family history – a negative result does not rule out other hemolytic anemias. Please consult with a hematologist or geneticist before making any treatment decisions.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License 9294403
Advisory: Do Not Discontinue Prescribed Medication
⚠️ Do not discontinue prescribed medication (e.g., folic acid, chronic transfusions) without consulting your treating physician. Genetic testing does not replace clinical management.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Patient unable to provide informed consent (mandatory genetic counselling required per Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Minors: Mandatory parental/guardian consent in compliance with UAE data protection and medical liability laws.
- Sample Rejection: Clotted blood, insufficient DNA, or expired FTA card.
- Red Flag Symptoms – Seek immediate medical attention: Severe pallor, dark urine, or acute neurological deterioration (e.g., ataxia, seizures) during test waiting period.
- Contraindication: No test if active hemolytic crisis suspected; stabilize first.
Patient FAQ & Clinical Guidance
1. What is the TPI1 NGS test and when is it recommended?
First‑sentence snippet: The TPI1 NGS sequences the entire TPI1 gene from blood or DNA to identify disease‑causing mutations, recommended when hemolytic anemia of unknown origin or neurological regression suggests triosephosphate isomerase deficiency.
It is ideal for patients with unexplained non‑spherocytic hemolytic anemia, early‑onset neuromuscular decline, or a family history of enzymopathy. Genetic counselling is mandatory before sample collection.
2. How is the sample collected, and what does the 3‑to‑4‑week turnaround entail?
First‑sentence snippet: A certified phlebotomist collects blood or accepts buccal/DNA FTA card samples under cold‑chain conditions, and the 3‑to‑4‑week TAT covers sequencing, variant interpretation, and a DHA‑standard report.
Home collection is available across UAE 8 AM–11 PM. FTA cards allow remote sampling for patients who cannot visit. The report includes pathogenicity classification (ACMG/AMP) and clinical notes from our genetic counselling team.
3. Are the results confidential and compliant with UAE privacy laws?
First‑sentence snippet: Yes, all genetic data is protected under Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019, and stored on encrypted Dubai‑based servers without third‑party sharing.
Consent forms explicitly detail data usage. Parents/guardians can authorise testing for minors in line with UAE medical liability and data protection regulations. Reports are only released to the requesting DHA‑licensed physician.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: All genetic test results are handled in strict compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted in transit and at rest on secure servers located in Dubai. Informed consent for genetic testing is obtained per Federal Decree‑Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds DHA Facility License No. 1143 and adheres to all applicable standards for genetic testing and reporting.
Clinical & Logistical Metadata
| Test Name | TPI1 Gene Hemolytic Anemia due to Triosephosphate Isomerase Deficiency Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or FTA card (peripheral blood accepted) |
| Methodology Used | Next‑Generation Sequencing (full gene coverage ±20 bp flanking) |
| ICD-10-CM Code | D55.2 (Hemolytic anemia due to disorders of glycolytic enzymes) |
| LOINC Code | 48018-6 (Gene mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | DHA License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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