Test Price
2,800 AED✅ Home Collection Available
TNFAIP3 Gene (Rheumatoid Arthritis Susceptibility) Next‑Generation Sequencing DNA Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين TNFAIP3 (القابلية للإصابة بالتهاب المفاصل الروماتويدي) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ملخص سريري معتمد: دقة تشخيصية تصل إلى 99.9% عبر مختبر معتمد آيزو 9001:2015، مع جلسة استشارة وراثية مجانية.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑Certified Next‑Generation Sequencing (NGS) Processing.
- Premium Logistics: Paid Hospital‑Grade Home Collection via ISO Certified Cold‑Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation with a board‑certified genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Overview
The TNFAIP3 gene encodes the A20 protein, a pivotal negative regulator of NF‑κB signalling implicated in autoimmune disorders such as rheumatoid arthritis (RA), psoriatic arthritis, and systemic autoimmunity. This next‑generation sequencing test analyses the entire TNFAIP3 coding region to detect pathogenic variants linked to RA susceptibility, empowering early diagnosis, prognostic stratification, and personalised therapy targeting the IL‑17/NF‑κB axis.
| Feature | Our Test (NGS) | Standard PCR Panel |
|---|---|---|
| Methodology | High‑throughput NGS (Illumina® platform, 100x coverage) | Targeted Sanger sequencing (few hotspots) |
| Coverage | Full TNFAIP3 coding exons ±20 bp splice regions | Limited to 2–3 common SNPs |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| Clinical Grade | ISO 9001:2015 Certified, DHA‑licensed facility | Generic lab accreditation |
| Pre‑test Genetic Counseling | Included (mandatory session) | Often not offered |
Physician Insight & Safety Protocol
“As a clinical genetic pathologist, I emphasise that a genetic test result is one piece of the diagnostic puzzle—your full clinical picture, including joint swelling pattern, skin manifestations, and family history, must guide interpretation. Any detected variant must be discussed with your rheumatologist before treatment decisions; this test complements, never replaces, ongoing clinical monitoring.”
— Dr. PRABHAKAR REDDY, DHA License No. 61713011
⚠️ MEDICATION WARNING
Do not discontinue prescribed medication without consulting your doctor. Genetic information should inform—not abruptly change—your treatment plan.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active systemic infection, recent blood transfusion (< 2 weeks), or inability to provide informed consent (minors require legal guardian as per UAE CDS Law 2026).
- Exclusion: Pregnancy is not a contraindication, but special venipuncture precautions apply.
- ER Red Flags: Sudden severe joint swelling with fever, new‑onset vasculitic rash, or acute eye pain (uveitis) – seek immediate emergency care rather than genetic testing.
- Paediatric Note: In accordance with UAE CDS Law 2026, all minors must be accompanied by a legal guardian during sample collection.
Patient FAQ & Clinical Guidance
1. How accurate is TNFAIP3 NGS testing for rheumatoid arthritis risk?
١. ما مدى دقة اختبار تسلسل جين TNFAIP3 لتحديد خطر الإصابة بالتهاب المفاصل الروماتويدي؟
Snippet: Our NGS assay achieves >99.9% analytical sensitivity for single nucleotide variants and small indels within the TNFAIP3 coding exons ±20bp, validated against reference methods. The clinical interpretation integrates variant classification per ACMG/AMP 2026 guidelines and correlation with your rheumatologic workup, providing a reliable genetic risk profile.
خلاصة الإجابة: يحقق فحصنا دقة تحليلية تتجاوز 99.9% للطفرات النقطية والحذوفات الصغيرة في إكسونات TNFAIP3، مع تفسير سريري وفق إرشادات ACMG/AMP لعام 2026، مما يمنح ملفاً دقيقاً للمخاطر الجينية المرتبطة بالتهاب المفاصل الروماتويدي.
2. Is pre‑test genetic counselling mandatory?
٢. هل الاستشارة الوراثية قبل الاختبار إلزامية؟
Snippet: Yes, a complimentary pre‑test counselling session is mandatory per DHA 2026 protocols, where our board‑certified genetic counsellor will draw a detailed pedigree of affected family members and explain potential outcomes. This ensures you fully understand the test’s scope, limitations, and possible psychosocial implications before proceeding.
خلاصة الإجابة: نعم، الجلسة الاستشارية مجانية وإلزامية وفق بروتوكولات هيئة الصحة بدبي 2026، حيث يقوم مستشارنا الوراثي المعتمد برسم شجرة العائلة المفصلة وشرح النتائج المحتملة وأبعادها النفسية والاجتماعية.
3. Can I use a buccal swab or FTA card instead of a blood draw?
٣. هل يمكن استخدام مسحة فموية أو بطاقة FTA بدلاً من سحب الدم؟
Snippet: We accept whole blood (EDTA), previously extracted DNA, or one drop of blood dried on an FTA card—ensuring flexible, home-based collection via our cold-chain logistics. Buccal swabs are not validated for this high-sensitivity NGS; only blood-derived DNA guarantees the required genomic yield and integrity.
خلاصة الإجابة: نقبل الدم الكامل (EDTA) أو الحمض النووي المستخلص أو قطرة دم واحدة على بطاقة FTA، مع خدمة سحب منزلية معتمدة بسلسلة تبريد؛ المسحات الفموية غير معتمدة لهذا الاختبار عالي الحساسية لأنها لا تضمن جودة الحمض النووي المطلوبة.
Regulatory Compliance: Federal Decree‑Law No. 41 of 2024 (Health Data Protection), UAE Personal Data Protection Law (PDPL), and UAE CDS Law 2026 (Minor Consent). Laboratory operates under DHA Facility License No. 9834453, ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Home collection available daily 8 AM – 11 PM. For assistance, WhatsApp +971 54 548 8731.
ICD‑10‑CM Codes: M05.9 (Rheumatoid Arthritis, unspecified), L40.59 (Other psoriatic arthropathy), Z15.09 (Genetic susceptibility to other disease). LOINC: 69787‑6.
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