Test Price
2,800 AED✅ Home Collection Available
TMEM38B Gene Osteogenesis Imperfecta Type 14 Genetic Test in UAE | 2,800 AED | DHA-Compliant
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed genetic counselors.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This NGS test sequences the entire coding region of the TMEM38B gene to diagnose Osteogenesis Imperfecta type 14, a rare autosomal recessive bone fragility disorder. In the UAE, our ISO-certified lab delivers a clinically actionable report within 3–4 weeks, integrating advanced bioinformatics and DHA-standard reporting.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% sensitivity, full gene coverage | 90-95% on targeted panels |
| Method | NGS with MLPA reflex for copy number variants | NGS only, may miss large deletions |
| Turnaround Time | 3-4 Weeks (expedited available) | 4-6 Weeks |
Physician Insight & Safety Protocols
“This genetic test is a critical tool for confirming Osteogenesis Imperfecta type 14, but results must always be interpreted alongside clinical and radiological assessments. A negative finding does not fully exclude the condition, and any positive result warrants structured genetic counselling. Patients should never alter or stop prescribed therapies without prior consultation with their treating physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice on Medication Continuity
Discontinuing prescribed calcium, vitamin D, or bisphosphonate therapy without medical guidance may increase fracture risk. This diagnostic test does not replace ongoing clinical management; always consult your doctor before making any changes to your treatment regimen.
Exclusion Criteria & Emergency Red Flags
- Specimen not collected in the prescribed DNA-stabilizing tube; haemolysed samples rejected.
- Inability to provide informed consent (for minors or guardians under UAE Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Seek emergency care if recent or worsening bone pain, swelling, or inability to bear weight—do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the accuracy of the TMEM38B NGS test for Osteogenesis Imperfecta type 14?
Our laboratory achieves over 99.9% diagnostic sensitivity through full gene sequencing, confirmatory Sanger verification of pathogenic variants, and dual-bioinformatician review. The test detects point mutations, small insertions or deletions, and when combined with MLPA, large deletions that routine panels may miss.
2. Does this test require fasting or medication cessation before sample collection?
No fasting or medication discontinuation is needed for this genetic test. However, please inform your physician of all supplements and medications you are taking. The sample can be collected from peripheral whole blood or extracted DNA via our VIP Mobile Phlebotomy service.
3. What pre-test information and genetic counselling are required?
A comprehensive clinical history including a three-generation pedigree chart of family members affected with bone fragility must be submitted. We strongly recommend a pre-test genetic counselling session to discuss inheritance patterns and implications—this is mandatory under Federal Decree-Law No. 4 of 2016 on Medical Liability for informed consent.
UAE Regulatory & Data Privacy Adherence
All genetic data processing and storage comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent, data anonymization, and secure transmission protocols are strictly enforced throughout the testing lifecycle. DNA Labs UAE is fully licensed by the Dubai Health Authority (DHA) under Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | TMEM38B Gene Osteogenesis Imperfecta Type 14 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (expedited available) |
| Sample Type / Matrix | Peripheral Whole Blood (DNA-stabilizing tube) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with MLPA reflex for copy number variant detection |
| ICD-10-CM Code | Q78.0 |
| LOINC Code | 21643-8 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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