Test Price
2,800 AED✅ Home Collection Available
TMEM38B Gene Osteogenesis Imperfecta Type 14 Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
DHA-Compliantتحليل جين TMEM38B لمرض تكون العظم الناقص النوع 14 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary (ملخص تنفيذي)
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed genetic counselors.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
يتم تنفيذ التحليل وفقًا لأحدث إرشادات هيئة الصحة بدبي لعام 2026 والقانون الاتحادي رقم 41 لسنة 2024 لضمان الدقة وسرية البيانات الجينية.
Overview
This NGS test sequences the entire coding region of the TMEM38B gene to diagnose Osteogenesis Imperfecta type 14, a rare autosomal recessive bone fragility disorder. In the UAE, our ISO-certified lab delivers a clinically actionable report within 3–4 weeks, integrating advanced bioinformatics and DHA-standard reporting.
يقوم هذا التحليل بتسلسل الجين TMEM38B لتشخيص مرض تكون العظم الناقص من النوع 14، وهو اضطراب وراثي نادر يسبب هشاشة العظام، ويقدم نتائجه خلال 3 إلى 4 أسابيع.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% sensitivity, full gene coverage | 90-95% on targeted panels |
| Method | NGS with MLPA reflex for copy number variants | NGS only, may miss large deletions |
| Turnaround Time | 3-4 Weeks (expedited available) | 4-6 Weeks |
Physician Insight & Safety Protocol
“This genetic test is a crucial step in confirming Osteogenesis Imperfecta type 14, but it must always be correlated with clinical and radiological findings. As a DHA-licensed specialist, I advise that a negative result does not entirely rule out the disorder, and positive results require careful genetic counselling. Never stop any prescribed medication or supplements without consulting your doctor.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
⚠️ Medication Warning: Do not discontinue prescribed medication without consulting your doctor.
This test is not a substitute for medical management; abrupt cessation of calcium/vitamin D therapy or bisphosphonates may lead to fractures.
Exclusion Criteria & Emergency Red Flags
- Specimen not collected in the prescribed DNA-stabilizing tube; haemolysed samples rejected.
- Inability to provide informed consent (for minors/guardians under UAE CDS Law 2026).
- Seek emergency care if recent or worsening bone pain, swelling, or inability to bear weight—do not wait for test results.
Patient FAQ & Clinical Guidance
1. How accurate is the TMEM38B NGS test for diagnosing Osteogenesis Imperfecta type 14?
Our laboratory achieves over 99.9% diagnostic sensitivity due to full gene sequencing, confirmatory Sanger verification of pathogenic variants, and dual-bioinformatician review. The test detects point mutations, small insertions/deletions, and when combined with MLPA, large deletions undetectable by routine panels.
2. هل يتطلب هذا الفحص صياماً أو امتناعاً عن الأدوية قبل سحب العينة؟
لا يحتاج تحليل جين TMEM38B إلى صيام أو وقف الأدوية؛ ولكن يُرجى إبلاغ الطبيب بجميع المكملات والأدوية لعدم إيقاف أي علاج دون استشارة. يمكن أخذ العينة من الدم الكامل أو الحمض النووي المستخلص.
3. What is the required pre-test information and genetic counselling?
A comprehensive clinical history, including a three-generation pedigree chart of family members affected with bone fragility, must be submitted. We strongly recommend a pre-test genetic counselling session to discuss inheritance patterns and implications—this is mandatory under Federal Decree-Law No. 41 of 2024 for informed consent.
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians