Test Price
2,800 AED✅ Home Collection Available
TGIF1 Gene Holoprosencephaly Type 4 Genetic Test (NGS) | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 certified NGS workflow, validated against global genomic databases.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across Dubai, Abu Dhabi, and Northern Emirates.
- Clinical Guidance: Complimentary telephonic post-test counselling with a genetic specialist to interpret TGIF1 variant reports within your family context.
- Insurance: Direct billing verification – send policy details via WhatsApp to +971 54 548 8731.
Test Overview & Methodology
The TGIF1 Gene Holoprosencephaly Type 4 Genetic Test uses next‑generation sequencing (NGS) to analyze the complete coding region and splice sites of the TGIF1 gene. This test detects pathogenic variants responsible for holoprosencephaly type 4, a severe congenital brain malformation where the forebrain fails to divide properly. Early molecular diagnosis enables precise prognosis, informed family planning, and recurrence risk assessment.
| Feature | Our TGIF1 NGS Test | Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next Generation Sequencing – full gene coverage | Sanger – limited to known hotspots |
| Analytical Sensitivity | >99.9% for SNVs and small indels | ~95% for targeted regions |
| Turnaround Time | 3–4 weeks with expert bioinformatic review | 4–6 weeks, minimal variant interpretation |
| Sample Options | Whole Blood (EDTA), Extracted DNA, or FTA Card | Whole blood only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA License: 9294403) shares: “This NGS-based test delivers a definitive molecular diagnosis for holoprosencephaly type 4, essential for guiding neurosurgical management, family counselling, and recurrence risk estimation. It is critical to correlate genetic findings with neuroimaging and clinical phenotypes, as variants of uncertain significance may necessitate segregation studies. I recommend pre-test genetic counselling to address the emotional and ethical dimensions before proceeding.”
Medication Advisory
⚠️ Important Notice
Do not discontinue any prescribed medication, including anti-epileptic drugs or hormonal therapies, without consulting your treating physician. This test does not interfere with routine medications and no special preparation is needed.
Safety Exclusion Criteria & Red Flags
- Exclusion Criteria: Active coagulopathy or severe thrombocytopenia precluding safe venipuncture; inability to provide 0.5 mL whole blood or equivalent DNA.
- Emergency Red Flags – Seek Immediate Medical Attention: New-onset seizures, apnoeic spells, bulging fontanelle, or signs of raised intracranial pressure (projectile vomiting, sunsetting eyes) in an infant with suspected holoprosencephaly.
- Sample Integrity: FTA cards must be completely dried and free from contamination; haemolysed or clotted blood may lead to test cancellation.
Patient FAQ & Clinical Guidance
1. What exactly does the TGIF1 NGS test detect?
This test identifies pathogenic mutations in the entire TGIF1 gene that cause holoprosencephaly type 4, enabling precise diagnosis, prognosis, and recurrence risk assessment for families.
2. How long will it take to receive the results?
Your final interpreted report will be ready within 3 to 4 weeks from sample receipt, including thorough bioinformatic curation and clinical correlation.
3. Is home blood collection available across the UAE?
Yes, our DHA-licensed mobile phlebotomy team provides cold-chain home collection from 8 AM to 11 PM daily throughout Dubai, Abu Dhabi, and the Northern Emirates for whole blood, extracted DNA, or FTA card samples.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
Data Protection: All genetic data is processed in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning the Use of Information and Communication Technology in Health Fields.
Clinical Safety: Patient consent and safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Accreditation: ISO 9001:2015 Certified – Cert. No. INT/EGQ/2509DA/3139. Sample handling and analysis are performed in DHA-licensed facilities.
Clinical & Logistical Metadata
| Test Name | TGIF1 Gene Holoprosencephaly Type 4 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks (14–21 business days from sample receipt) |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next Generation Sequencing (NGS) – Full gene coverage |
| ICD-10-CM Code | Q04.2 (Holoprosencephaly) |
| LOINC Code | 55233-1 (Genetic analysis panel – Blood) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | DNA Labs UAE – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians