Test Price
2,800 AED✅ Home Collection Available
TGIF1 Gene Holoprosencephaly Type 4 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين TGIF1 للكشف عن انعدام تنسج الدماغ الشامل من النوع 4 عبر التسلسل الجيني من الجيل التالي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Workflow, validated against 2026 AI‑driven genomic datasets.
- Premium Logistics: Paid Hospital‑Grade Home Collection with ISO‑Certified Cold‑Chain Transport for whole blood, extracted DNA, or FTA card samples.
- Clinical Guidance: Complimentary telephonic post‑test counselling to interpret TGIF1 variant reports within the patient’s clinical context.
- Insurance: Direct Billing Verification – send policy details via WhatsApp to +971 54 548 8731.
ملخص تنفيذي: يضمن هذا الفحص الجيني المتطور دقة تشخيصية بنسبة 99.9%، مع إمكانية السحب المنزلي المعتمد بتقنية النقل المبرّد الحاصلة على شهادة الأيزو، وإرشاد طبي هاتفي بعد النتائج، والتثبت المباشر من التغطية التأمينية عبر الواتساب.
Test Overview
The TGIF1 Gene Holoprosencephaly Type 4 Genetic Test is a next‑generation sequencing analysis that reads the entire coding region of the TGIF1 gene to identify pathogenic variants responsible for the most severe form of holoprosencephaly – a congenital brain malformation where the forebrain fails to divide normally. يُجري هذا الاختبار تسلسلًا كاملاً لجين TGIF1 باستخدام تقنية الجيل التالي لتحديد الطفرات المسببة لانعدام تنسج الدماغ الشامل من النوع الرابع، وهي حالة تشوه خلقي حاد في الدماغ.
| Feature | Our TGIF1 NGS Test | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) – full gene coverage | Sanger sequencing – limited to known hotspots |
| Analytical Sensitivity | >99.9% for single nucleotide variants & small indels | ~95% for targeted regions only |
| Turnaround Time | 3–4 weeks with bioinformatic expert review | 4–6 weeks, often without in‑depth variant interpretation |
| Sample Options | Whole Blood (EDTA), Extracted DNA, or FTA Card | Blood only |
Physician Insight & Safety Protocol
Dr. PRABHAKAR REDDY (DHA License: 61713011) shares: “This test provides a definitive molecular diagnosis that is critical for planning neurosurgical interventions, guiding family counselling, and predicting recurrence risk. However, a positive result should always be correlated with neuroimaging and clinical findings, as variants of uncertain significance may require additional family studies. I strongly advise parents to discuss the emotional and ethical aspects with our genetic counsellor before testing.”
⚠️ Clinical Notice
Do not discontinue any prescribed medication, including anti‑epileptic drugs or hormonal therapies, without consulting your treating physician. This test does not interfere with routine medications and no special preparation is needed.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active coagulopathy or severe thrombocytopenia precluding safe venipuncture; inability to provide a minimum of 0.5 mL whole blood or equivalent DNA.
- Emergency Red Flags – Seek Immediate Medical Attention: New‑onset seizures, apnoeic spells, bulging fontanelle, or signs of raised intracranial pressure (projectile vomiting, sunsetting eyes) in an infant with suspected holoprosencephaly.
- Sample Integrity: FTA cards must be completely dried and protected from contamination; haemolysed or clotted blood may lead to test cancellation.
Frequently Asked Questions
1. What exactly does the TGIF1 NGS test detect?
Snippet: This identifies harmful mutations in the entire TGIF1 gene that cause holoprosencephaly type 4, enabling precise diagnosis, prognosis, and reproductive risk assessment.
يكشف هذا الاختبار الطفرات الضارة في جين TGIF1 المسؤولة عن انعدام تنسج الدماغ الشامل من النوع الرابع، مما يتيح تشخيصًا دقيقًا وتقديرًا للمآل وتقييمًا لخطر التكرار في الحمل.
2. How long will it take to receive the results?
Snippet: Your child’s final interpreted report will be ready within 3 to 4 weeks from sample receipt, including thorough bioinformatic curation and clinical correlation.
سيصدر تقرير طفلك النهائي والمفسر سريريًا خلال فترة تتراوح بين 3 و4 أسابيع من استلام العينة، ويشمل ذلك عملية تنقيح حاسوبي ومطابقة سريرية شاملة.
3. Is home blood collection available in the UAE?
Snippet: Yes, our DHA‑licensed mobile phlebotomy team performs cold‑chain home collection (8 AM – 11 PM) anywhere in Dubai, Abu Dhabi, and the Northern Emirates.
نعم، يقوم فريقنا المرخص من هيئة الصحة بدبي بسحب العينات منزليًا مع الحفاظ على سلسلة التبريد في أي مكان داخل دبي وأبو ظبي والإمارات الشمالية من الساعة 8 صباحًا حتى 11 مساءً.
UAE Healthcare Compliance: This service adheres to Federal Decree‑Law No. 41 of 2024 (Article 87) on healthcare quality and safety, the 2026 Child Data Security (CDS) Law for minors’ genetic data, and UAE Personal Data Protection Law (PDPL) for all sample and report handling.
Accreditation: ISO 9001:2015 Certified – Cert. No. INT/EGQ/2509DA/3139; Laboratory License: 9834453.
Contact: Support & WhatsApp: +971 54 548 8731 | All WhatsApp billing verifications are encrypted end‑to‑end.
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التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians