Test Price
2,800 AED✅ Home Collection Available
TENM1 Gene Colobomatous Microphthalmia Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Licensed Sequencing Pipeline.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic post-test result interpretation with a DHA-licensed genetic counsellor.
- Insurance: Direct Billing Verification – send your policy details via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced genetic test sequences the entire coding region of the TENM1 gene using Next Generation Sequencing (NGS) to identify pathogenic variants linked to colobomatous microphthalmia, a severe congenital eye malformation. The analysis covers all coding exons plus ±10 base pairs of flanking splice sites, ensuring high sensitivity for single nucleotide variants, small insertions and deletions, and copy number changes.
| Feature | Our Test (TENM1 NGS) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | 100% coverage of TENM1 coding exons ±10 bp splice sites | Partial coverage; may miss deep intronic variants |
| Method | NGS with Illumina® SBS chemistry, confirmed by Sanger sequencing | NGS via whole exome capture, lower depth on single gene |
| Turnaround | 3–4 Weeks | 6–8 Weeks (often delayed by incidental findings analysis) |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specialist, I recognize the emotional weight that accompanies genetic testing for a congenital eye condition. The TENM1 gene analysis provides definitive molecular confirmation of colobomatous microphthalmia and enables accurate recurrence risk counselling for families. However, genetic results must always be integrated with a comprehensive ophthalmologic evaluation and a detailed three-generation pedigree. A positive finding clarifies the aetiology, yet clinical management remains a shared decision between you, your ophthalmologist, and your genetic counsellor." – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Advisory
Do not discontinue prescribed medication without consulting your doctor. This genetic test does not replace an emergency ophthalmologic evaluation.
Exclusion Criteria
- Not suitable for individuals without a clinical suspicion or family history of colobomatous microphthalmia.
- Minors must be accompanied by a legal guardian; consent must follow UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Do not use this test as a stand-alone prenatal screen without prior genetic counselling.
Emergency Red Flags (seek immediate care)
- Sudden loss of vision, severe eye pain, or trauma.
- Signs of acute infection at the blood collection site.
- Any unexpected reaction after specimen collection.
Patient FAQ & Clinical Guidance
1. What is the TENM1 gene colobomatous microphthalmia NGS test?
This NGS test analyzes the TENM1 gene to identify mutations causing colobomatous microphthalmia, a hereditary eye condition characterised by microphthalmia (small eye) and coloboma (missing tissue in eye structures). It examines the complete coding sequence of the gene to detect single nucleotide variants, small deletions, and copy number changes. The result helps confirm a clinical diagnosis, guides surveillance for associated anomalies, and informs recurrence risk for family members.
2. How should I prepare for the test and what sample is required?
A blood sample (whole blood, dried blood spot on FTA card, or extracted DNA) is required with no fasting needed. A pre-test genetic counselling session is mandatory to collect a detailed family history and draw a pedigree chart that includes all relatives affected by microphthalmia or coloboma. Please provide any previous ophthalmology reports. Our VIP mobile phlebotomy team will handle the temperature-controlled cold-chain transport directly to your home.
3. Is this test covered by insurance in the UAE?
Many UAE insurers cover the TENM1 NGS test when pre-authorised and supported by a referral from an ophthalmologist. Our billing team verifies your coverage directly via WhatsApp (+971 54 548 8731) before the appointment. A letter of medical necessity may be required. For self-pay patients, the total cost is 2800 AED.
UAE Regulatory & Data Privacy Adherence
This service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All laboratory processing is performed at DNA Labs UAE, a facility licensed under DHA Facility License No. 1143, accredited to ISO 9001:2015. Your genetic data is encrypted, access-controlled, and never shared without your explicit written consent.
Clinical & Logistical Metadata
| Test Name | TENM1 Gene Colobomatous Microphthalmia NGS Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Dried Blood Spot (FTA Card), or Extracted DNA |
| Methodology Used | Next Generation Sequencing (NGS) – Illumina® SBS chemistry with Sanger confirmation |
| ICD-10-CM Code | Q11.2, Q12.2 |
| LOINC Code | 48018-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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