Test Price
2,800 AED✅ Home Collection Available
TAF2 Gene MRT40 Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Test Overview & Methodology
TAF2 Gene Sequencing (MRT40) is a targeted Next-Generation Sequencing (NGS) assay designed to detect pathogenic and likely pathogenic variants in the TAF2 gene, definitively causing autosomal recessive mental retardation type 40 (MRT40). This test provides a conclusive molecular diagnosis for individuals presenting with early-onset intellectual disability and global developmental delay, enabling accurate recurrence risk assessment for families.
| Feature | Our TAF2 NGS Test | Whole Exome Sequencing (Alternative) |
|---|---|---|
| Precision | Single-gene resolution with deep coverage (≥100x) of all TAF2 exons and splice sites | Genome-wide exome, but variable per-gene coverage; may miss deep intronic or low-coverage regions |
| Analytical Method | NGS + mandatory Sanger validation of all pathogenic/likely pathogenic variants | NGS only; secondary confirmation not routinely performed |
| Turnaround Time | 3–4 Weeks | Typically 6–8 Weeks |
| Clinical Utility | Direct answer for MRT40 – ideal for confirmatory testing and targeted family screening | Broad diagnostic work-up; potential for incidental findings requiring secondary analysis |
| Cost (UAE) | 2800 AED | ~4500–6000 AED |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403):
“A definitive molecular diagnosis of MRT40 through TAF2 sequencing empowers families with accurate recurrence risk assessments and allows for early therapeutic interventions. It is crucial to interpret these results within the complete clinical context of the patient and family history.”
Medication Advisory & Clinical Caution
This genetic test result is for diagnostic and informational purposes only. It does not constitute a directive to alter or discontinue any prescribed medication or therapy. All clinical management decisions must be made in consultation with your treating physician.
Safety Exclusion Criteria & Emergency Red Flags
🔴Exclusion Criteria (Do Not Proceed Without Specialist Clearance)
- Acute neurological deterioration requiring immediate emergency stabilization.
- Patient globally unresponsive or severely encephalopathic without a legal guardian present to provide informed consent.
- Active systemic infection or febrile illness potentially compromising specimen integrity.
- Documented severe coagulopathy without prior hematology or physician approval for venipuncture.
🚨Urgent Red Flags – Seek Immediate Medical Attention
- New-onset loss of consciousness or prolonged, uncontrolled seizures.
- Rapid regression of previously attained developmental milestones (e.g., speech, motor skills).
- Severe behavioural changes, self-injurious actions, or escalating aggression.
- Signs indicative of elevated intracranial pressure (persistent vomiting, lethargy, bulging fontanelle in infants).
Patient FAQ & Clinical Guidance
1. What is the TAF2 Gene MRT40 Genetic Test?
This targeted Next-Generation Sequencing (NGS) test analyzes the TAF2 gene to identify disease-causing mutations responsible for autosomal recessive intellectual disability type 40 (MRT40). It provides a definitive molecular diagnosis, enabling precise genetic counseling and informed family planning decisions.
2. How is the sample collected for the TAF2 Genetic Test?
A certified and experienced phlebotomist visits your home, office, or hotel anywhere in the UAE between 8 AM and 11 PM to collect a standard peripheral whole blood sample. The specimen is transported using our ISO-compliant, temperature-controlled cold-chain logistics to ensure optimal DNA integrity for analysis.
3. How long does the TAF2 test take, and what do results mean?
Results are typically available within 3 to 4 weeks. A positive report identifies a pathogenic TAF2 variant confirming MRT40. A negative report significantly reduces the likelihood of TAF2-related MRT40, though clinical correlation is still essential, and a comprehensive clinical evaluation is recommended regardless of the result.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with the UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, maintaining the highest standards of patient confidentiality, data security, and health information governance. All clinical testing safety and patient consent protocols strictly adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring every procedure is ethically and legally sound.
Clinical & Logistical Metadata
| Test Name | TAF2 Gene MRT40 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Cold-Chain Transport) |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) with Sanger Validation |
| ICD-10-CM Code | F70, F79 |
| LOINC Code | 82306-7 |
| DHA Facility License & Address | DNA Labs UAE | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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