Test Price
2,800 AEDโ Home Collection Available
TACR3 Gene Hypogonadotropic Hypogonadism Type 11 Genetic Test in UAE
99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing.
Premium Home Collection: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Logistics (8 AMโ11 PM).
Clinical Guidance: Telephonic Post-Test Result Interpretation by DHA-Licensed Genetics Experts.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Executive Summary & Core Metrics
2,800 AED โ Comprehensive TACR3 gene analysis for congenital hypogonadotropic hypogonadism type 11 (with or without anosmia). This definitive molecular diagnostic test utilizes Next-Generation Sequencing (NGS) to achieve 99.9% sensitivity across the entire coding region and splice junctions. Turnaround time is 3โ4 weeks from sample receipt. All results are reviewed and interpreted by a Consultant Medical Genetics specialist holding a valid DHA license.
Test Overview & Methodology
The TACR3 genetic test uses Next-Generation Sequencing (NGS) to detect pathogenic and likely pathogenic variants in the TACR3 gene, which is associated with congenital hypogonadotropic hypogonadism type 11. Identification of a causative mutation enables targeted hormone replacement therapy and informed family planning. The analysis covers all coding exons, intronic boundaries, and known regulatory regions, with variant classification per ACMG/AMP guidelines.
| Feature | DNA Labs UAE | Standard Alternative |
|---|---|---|
| Methodology | Full TACR3 Gene NGS (99.9% Sensitivity) | Sanger Sequencing (limited to known hotspots) |
| Turnaround Time | 3โ4 Weeks | 6โ8 Weeks |
| ISO Accreditation | ISO 9001:2015 | Often non-certified |
Physician Insight & Safety Protocols
โA molecular diagnosis of hypogonadotropic hypogonadism can be life-changingโit provides a clear biological target for therapy and resolves years of diagnostic uncertainty. However, the TACR3 result must be integrated with the patientโs endocrine profile, bone age, and family pedigree to avoid misinterpretation. I recommend this test for any individual with delayed puberty, anosmia, or unexplained infertility where a genetic basis is suspected.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory: Hormone Therapy Continuation
Patients currently receiving testosterone, estrogen, or gonadotropin therapy must not discontinue or alter their regimen without direct consultation with their treating endocrinologist or reproductive specialist. Abrupt cessation of sex-steroid therapy can result in bone density loss, mood disturbances, and metabolic dysregulation. This test is intended to guide future management, not to interrupt ongoing treatment.
Exclusion Criteria & Emergency Red Flags
- Age under 18: Requires legal guardian consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability and standard UAE pediatric consent protocols.
- Acute medical instability: Not intended for emergency diagnostics; defer testing if the patient is acutely unwell or hospitalized.
- Hormonal washout period: Certain sex-steroid or GnRH therapies may alter the clinical phenotype; a washout interval under medical supervision is advised if clinically appropriate.
- Seek immediate emergency care if: You experience suicidal ideation, severe depression, sudden vision loss, or acute deterioration in general health after receiving genetic results.
Patient FAQ & Clinical Guidance
1. Who should consider this TACR3 genetic test?
Answer: Individuals with delayed or absent puberty, low libido, anosmia (inability to smell), infertility, or a documented family history of hypogonadotropic hypogonadism should consider this test. It is also relevant for patients with unexplained low testosterone or estrogen levels despite normal pituitary imaging.
2. What do the results mean for my treatment and fertility options?
Answer: A confirmed pathogenic TACR3 mutation establishes the genetic basis of your condition, which directly informs personalized hormone replacement therapy (testosterone, estrogen, or gonadotropins) and assisted reproductive strategies. In many cases, appropriate hormonal stimulation can restore fertility. Your genetic counselor and endocrinologist will create a tailored plan based on your specific variant and clinical profile.
3. How does the home collection process work and what are the preparation steps?
Answer: A DHA-licensed phlebotomist arrives at your residence in a marked medical vehicle equipped with a temperature-controlled cold-chain kit. The blood draw takes approximately 10 minutes. No special preparation or fasting is required for this genetic test, but please inform the phlebotomist of any current medications. The sample is transported directly to our ISO 9001:2015 certified laboratory for processing.
UAE Regulatory & Data Privacy Adherence
Data Protection: All genetic data is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient specimens and derived genomic information are encrypted, access-controlled, and never shared with third parties without explicit written consent.
Clinical Safety & Consent: Sample collection and diagnostic reporting adhere to the standards set by Federal Decree-Law No. 4 of 2016 on Medical Liability. All patients receive a pre-test genetic counseling session, and written informed consent is obtained prior to analysis. The laboratory holds ISO 9001:2015 certification and operates under DHA Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | TACR3 Gene Hypogonadotropic Hypogonadism Type 11 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Analysis |
| ICD-10-CM Code | E23.0 |
| LOINC Code | 81265-7 |
| DHA Facility License & Laboratory Address | DHA License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians