Test Price
2,800 AED✅ Home Collection Available
SYNE1 Gene Spinocerebellar Ataxia Type 8 (Autosomal Recessive) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189 accredited Next-Generation Sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test consultation with a DHA-licensed medical geneticist to interpret results.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The SYNE1 Gene NGS Test detects pathogenic variants causing autosomal recessive spinocerebellar ataxia type 8 (SCAR8), a progressive neurological disorder characterized by cerebellar atrophy, ataxia, and variable systemic involvement. Next-Generation Sequencing provides comprehensive coverage of the coding region and splice sites at >30x depth.
| Feature | Our SYNE1 NGS Test (DHA‑Licensed) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | Full coding region + splice site coverage with >30x depth; 99.9% analytical sensitivity | Targeted analysis of known mutations only; may miss novel variants |
| Methodology | Next‑Generation Sequencing (NGS) on Illumina platform | Sanger sequencing – limited to a few amplicons |
| Turnaround Time | 3–4 weeks with genetic counselling support | 6–8 weeks, often without integrated counselling |
Physician Insight & Safety Protocols
“The SYNE1-associated ataxia is exquisitely sensitive to genetic diagnosis, which can prevent a long diagnostic odyssey. However, a negative result must be interpreted in the clinical context—other hereditary ataxias or acquired causes may mimic SCAR8. I strongly recommend pairing this test with a formal neurological examination and genetic counselling before and after the report is issued.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Advisory
Do not discontinue any prescribed medication (especially anti‑epileptics, muscle relaxants, or antidepressants) without consulting your treating physician. Abrupt withdrawal can precipitate severe neurological deterioration.
Safety & Exclusion Criteria
- Exclusion: Patients with severe anaemia or haemodynamic instability that preclude safe venepuncture—discuss alternative DNA collection (buccal swab/dried blood spot) if needed.
- ER Red Flags: If the patient experiences acute neurological decline (sudden loss of ambulation, dysphagia with choking, respiratory distress), proceed immediately to the nearest emergency department regardless of genetic test status.
- Minors: Genetic testing in individuals under 18 requires explicit consent from a legal guardian in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability and DHA regulations.
- Pre‑Test Genetic Counselling: A certified genetic counselling session is mandatory to draw a detailed pedigree chart and explain the implications, as per DHA and MOHAP standards.
Patient FAQ & Clinical Guidance
1. What does a positive SYNE1 gene result mean for my neurological health?
A positive result confirms the diagnosis of autosomal recessive spinocerebellar ataxia type 8, which typically causes progressive gait and limb incoordination, dysarthria, and potential cognitive changes over years. Early identification allows targeted neurorehabilitation, family planning, and surveillance for extra‑neurological manifestations, though symptom onset and severity can vary even within the same family.
2. Can asymptomatic family members be tested?
Yes, carrier testing is available for adult siblings or relatives after genetic counselling. This evaluation assesses reproductive risk for having affected children and should only be performed with informed consent.
3. How is the sample collected and what preparation is needed?
A standard blood draw or a single drop of blood on an FTA card is collected by our DHA‑licensed phlebotomist during a home visit (8 AM‑11 PM). No fasting is required, but you must bring a valid Emirates ID, insurance card, and a completed genetic counselling referral form detailing the clinical history and pedigree chart. Avoid heavy muscular exertion immediately before collection to prevent non‑specific enzyme changes.
UAE Regulatory & Data Privacy Adherence
Data Protection: All patient data is processed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and consent protocols align with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Accreditations: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139), DHA Facility License 1143, and corporate laboratory branding as DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | SYNE1 Gene Spinocerebellar Ataxia Type 8 (Autosomal Recessive) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina platform |
| ICD-10-CM Code | G11.8, R27.0 |
| LOINC Code | 83511-4 |
| DHA Facility License & Laboratory Address | DHA Facility License 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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