Test Price
2,800 AED✅ Home Collection Available
SYNE1 Gene Spinocerebellar Ataxia Type 8 (Autosomal Recessive) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SYNE1 لرنح المخيخ الشوكي من النوع 8 المتنحي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189 Accredited Next‑Generation Sequencing.
- Premium Logistics: Paid Hospital‑Grade Home Collection via ISO‑Certified Cold‑Chain Transport, or VIP Mobile Phlebotomy (8 AM‑11 PM).
- Clinical Guidance: Telephonic Post‑Test Consultation with a DHA‑licensed Neurologist to interpret results.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
الملخص التنفيذي
يُقدّم تحليل جين SYNE1 بتقنية التسلسل الجيني المتقدم تشخيصًا دقيقًا لمرض رنح المخيخ الشوكي من النوع 8 المتنحي بأعلى معايير الجودة المتوافقة مع هيئة الصحة بدبي والقانون الاتحادي رقم (41) لسنة 2024. ضمان الدقة التشخيصية 99.9%، خدمة سحب منزلي على مدار الساعة، ودعم سريري بعد النتيجة – كل ذلك مع شفافية كاملة في الفوترة وحماية الخصوصية بموجب قانون حماية البيانات الشخصية.
Clinical Test Overview
The SYNE1 Gene NGS Test detects pathogenic variants causing autosomal recessive spinocerebellar ataxia type 8 (SCAR8), a progressive neurological disorder characterized by cerebellar atrophy, ataxia, and variable systemic involvement. يستهدف التحليل الطفرات المسببة لمرض رنح المخيخ الشوكي من النوع 8 المتنحي، مما يدعم التشخيص الدقيق والاستشارة الوراثية.
| Feature | Our SYNE1 NGS Test (DHA‑Licensed) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | Full coding region + splice site coverage with >30x depth; 99.9% analytical sensitivity | Targeted analysis of known mutations only; may miss novel variants |
| Methodology | Next‑Generation Sequencing (NGS) on Illumina platform | Sanger sequencing – limited to a few amplicons |
| Turnaround Time | 3–4 weeks with genetic counselling support | 6–8 weeks, often without integrated counselling |
Physician Insight & Safety Protocol
“The SYNE1‑associated ataxia is exquisitely sensitive to genetic diagnosis, which can prevent a long diagnostic odyssey. However, a negative result must be interpreted in the clinical context—other hereditary ataxias or acquired causes may mimic SCAR8. I strongly recommend pairing this test with a formal neurological examination and genetic counselling before and after the report is issued.”
— Dr. PRABHAKAR REDDY, Consultant Neurologist (DHA License: 61713011)
Medication Warning:
Do not discontinue any prescribed medication (especially anti‑epileptics, muscle relaxants, or antidepressants) without consulting your treating physician. Abrupt withdrawal can precipitate severe neurological deterioration.
Safety & Exclusion Criteria
- Exclusion: Patients with severe anaemia or haemodynamic instability that preclude safe venepuncture—discuss alternative DNA collection (buccal swab/dried blood spot) if needed.
- ER Red Flags: If the patient experiences acute neurological decline (sudden loss of ambulation, dysphagia with choking, respiratory distress), proceed immediately to the nearest emergency department regardless of genetic test status.
- Minors: Genetic testing in individuals under 18 requires explicit consent from a legal guardian in accordance with CDS Law 2026 and DHA regulations.
- Pre‑Test Genetic Counselling: A certified genetic counselling session is mandatory to draw a detailed pedigree chart and explain the’s implications, as per DHA and MOHAP standards.
Patient FAQ & Clinical Guidance
What does a positive SYNE1 gene result mean for my neurological health?
A positive result confirms the diagnosis of autosomal recessive spinocerebellar ataxia type 8, which typically causes progressive gait and limb incoordination, dysarthria, and potential cognitive changes over years. Early identification allows targeted neurorehabilitation, family planning, and surveillance for extra‑neurological manifestations, though symptom onset and severity can vary even within the same family.
هل يمكن إجراء الاختبار لأفراد العائلة غير المصابين؟
يمكن إجراء فحص الناقل للجين للأشقاء أو الأقارب البالغين بعد الاستشارة الوراثية، ويُستخدم لتقييم خطر إنجاب أطفال مصابين.
How is the sample collected and what should I do before the appointment?
A standard blood draw or a single drop of blood on an FTA card is collected by our DHA‑licensed phlebotomist during a home visit (8 AM‑11 PM). No fasting is required, but you must bring a valid Emirates ID, insurance card, and a completed genetic counselling referral form detailing the clinical history and pedigree chart. Avoid heavy muscular exertion immediately before collection to prevent non‑specific enzyme changes.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians