Test Price
2,800 AED✅ Home Collection Available
SULT2A1 Gene Polycystic Ovary Syndrome Type 1 Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity for SULT2A1 pathogenic variants via ISO‑accredited NGS processing.
- Price: 2,800 AED – inclusive of genetic counselling, sequencing, and post‑test interpretation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (available daily 8 AM to 11 PM) across all Emirates.
- Clinical Guidance: Complimentary tele‑phonic post‑test clinical interpretation by a DHA‑licensed Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 – approvals handled prior to collection.
Test Overview & Methodology
The SULT2A1 gene encodes a sulfotransferase enzyme essential for DHEA sulfation; pathogenic variants predispose to hyperandrogenism and type 1 PCOS. This NGS‑based genetic test (using peripheral whole blood, extracted DNA, or FTA card) identifies disease‑associated mutations with >99.9% accuracy, enabling definitive genetic diagnosis when standard hormone panels remain inconclusive.
| Feature | Our Test (NGS) | Closest Alternative (Standard PCOS Workup) |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity for SULT2A1 variants | Limited to hormonal/imaging findings; cannot identify monogenic etiology |
| Method | Next‑Generation Sequencing (Illumina‑based) with bioinformatic annotation | Serum androgens + pelvic ultrasound (Rotterdam criteria) |
| Speed | 3 – 4 Weeks (comprehensive report with clinical interpretation) | 1 – 2 days for lab results, but indefinite for definitive genetic diagnosis |
| Actionability | Enables precision therapy, familial risk assessment, and fertility planning | Empirical treatment; does not elucidate inherited risk |
Physician Insight & Safety Protocols
“A positive SULT2A1 variant test must be carefully correlated with clinical signs—hyperandrogenism, ovulatory dysfunction, and ovarian morphology—before confirming type 1 PCOS. This NGS assay provides precise genetic risk stratification that is invaluable for personalized management and family planning. Please continue all current prescribed therapies and discuss any adjustments only with your treating physician.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Advisory – Medication Continuation
Do not discontinue any prescribed medication without consulting your doctor. Genetic testing does not replace ongoing treatment; it merely informs future adjustments.
Exclusion Criteria & Emergency Red Flags
- Non‑consenting minor without legal guardian approval (UAE Federal Law).
- Recent blood transfusion (< 2 weeks) interfering with DNA extraction.
- ER Red Flag: Sudden severe pelvic pain, distension, or signs of ovarian torsion – seek immediate emergency care.
- Heavy vaginal bleeding with hemodynamic instability – call 998.
Patient FAQ & Clinical Guidance
1. What is the SULT2A1 gene and how does it relate to PCOS?
The SULT2A1 gene encodes a DHEA‑sulfating enzyme. Certain inherited variants significantly increase the risk of androgen‑driven type 1 PCOS. When enzyme activity is altered, DHEA is not adequately sulfated, leading to elevated free androgens. This genetic susceptibility, combined with environmental factors, manifests as irregular cycles, anovulation, and ovarian cysts. Our NGS test detects these pathogenic variants with >99.9% accuracy, providing a definitive molecular diagnosis that can guide fertility planning and metabolic management. Results must be interpreted alongside your clinical picture by your endocrinologist or gynecologist.
2. Is genetic counselling mandatory before this test?
Yes, a formal pre‑genetic counselling session is mandatory to draw a pedigree chart and explain possible variant outcomes. During counselling—required by DHA and UAE law—a clinical geneticist or trained counsellor maps your family history, estimates recurrence risks, and discusses implications of pathogenic, benign, or uncertain findings. This empowers informed consent. Counselling may be in‑clinic or via secure tele‑health, and must be completed before sample collection. No fee refund will be issued if counselling is omitted, as compliance with regulatory standards is non‑negotiable.
3. How long do results take and what does a positive result indicate?
Results are typically delivered in 3 to 4 weeks. A positive pathogenic SULT2A1 variant confirms a strong genetic predisposition to type 1 PCOS. The report details the exact mutation and its clinical significance according to ACMG guidelines. However, it does not mean you will inevitably develop full‑blown PCOS—phenotype depends on other genetic modifiers and lifestyle factors. A negative result reduces the likelihood of monogenic PCOS but does not exclude polygenic or non‑genetic causes. Your specialist will correlate findings with your hormonal profile and ultrasound to craft a tailored treatment plan, potentially including anti‑androgen therapy, ovulation induction, or assisted reproduction.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
- Data Protection: All patient data is handled in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety: Specimen collection and handling follow guidelines under Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient consent and sample integrity.
- Accreditation: DNA Labs UAE operates under DHA Facility License 1143 and maintains ISO‑15189 standards for molecular diagnostics.
Clinical & Logistical Metadata
| Test Name | SULT2A1 Gene Polycystic Ovary Syndrome Type 1 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (also accepted: extracted DNA, FTA card) – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina platform with bioinformatic variant annotation |
| ICD-10-CM Code | E28.2 (Polycystic ovarian syndrome) |
| LOINC Code | 86727-5 (SULT2A1 gene targeted mutation analysis) |
| DHA Facility License & Laboratory Address | DHA License 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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