Test Price
2,800 AED✅ Home Collection Available
SMAD3 Gene (Loeys‑Dietz Syndrome Type 1C) Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Diagnostic Precision & UAE-Compliant Care
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity — ISO 9001:2015 Certified NGS Laboratory.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Genetic Counseling for Result Interpretation.
- Insurance: Direct Billing Verification via WhatsApp: +971 54 548 8731.
- DHA Licensed: Facility License No. 1143 — Dubai Healthcare City.
Test Overview & Methodology
The SMAD3 gene NGS test screens for pathogenic variants linked to Loeys‑Dietz syndrome type 1C—a connective tissue disorder marked by arterial aneurysms, skeletal malformations, and cutaneous fragility. This test aids clinicians in confirming diagnosis, guiding surveillance, and informing familial risk. Next‑Generation Sequencing (NGS) targets the entire coding region with 100× minimum coverage, ensuring reliable detection of single‑nucleotide variants and small insertions/deletions.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) | Sanger Sequencing (limited coverage) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Sample Types | Whole Blood, Extracted DNA, Dried Blood Spot (FTA Card) | Whole Blood only |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that identification of a pathogenic SMAD3 variant confirms Loeys‑Dietz syndrome type 1C, yet comprehensive management requires integration with cardiovascular imaging, lifestyle modifications, and family cascade screening. Patients must not alter any prescribed therapy based solely on genetic results without a dedicated consultation with a certified geneticist or cardiologist.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not discontinue or modify prescribed medications (e.g., beta‑blockers, angiotensin receptor blockers) based solely on genetic test results. Consult your managing physician before any change. Adjustments to treatment plans require correlation with clinical findings and imaging surveillance.
Exclusion Criteria & Emergency Red Flags
- Active febrile illness or recent trauma may postpone elective phlebotomy.
- Test not performed on minors without guardian consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Seek emergency care immediately for acute chest pain, severe headache, sudden vision changes, or syncope—possible acute aortic syndrome.
Patient FAQ & Clinical Guidance
1. What is the accuracy of the SMAD3 gene test for diagnosing Loeys‑Dietz syndrome?
Our NGS‑based SMAD3 assay achieves 99.9% analytical sensitivity and specificity by sequencing the entire coding region with 100× minimum coverage, ensuring reliable detection of pathogenic and likely pathogenic variants.
2. How should I prepare for the SMAD3 genetic test sample collection?
Preparation involves completing a detailed clinical history form and, if possible, a genetic counseling session to document your family pedigree; no fasting or medication cessation is required unless advised by your physician.
3. Are home collection and insurance coverage available for this in the UAE?
Yes, we offer VIP mobile phlebotomy and temperature-controlled cold-chain home collection daily from 8 AM to 11 PM. Our insurance team can verify direct billing eligibility via WhatsApp at +971545488731 before scheduling.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
This genetic testing service is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted, access‑controlled, and processed solely for diagnostic purposes under the supervision of the Dubai Health Authority (DHA).
Accreditation: ISO 9001:2015 Certified (Cert No. INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | SMAD3 Gene (Loeys‑Dietz Syndrome Type 1C) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, Dried Blood Spot (FTA Card) |
| Methodology Used | Next Generation Sequencing (NGS) |
| ICD-10-CM Code | Q87.89 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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All reports reviewed by DHA-Certified physicians