Test Price
2,800 AED✅ Home Collection Available
SLCO1B3 Gene Hyperbilirubinemia (Rotor Type) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- ✓Accuracy: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next‑Generation Sequencing (NGS).
- ✓Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM).
- ✓Clinical Guidance: Complimentary telehealth post‑test interpretation with a consultant medical geneticist.
- ✓Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The SLCO1B3 gene test by NGS comprehensively analyzes mutations associated with Rotor‑type hyperbilirubinemia, a hereditary conjugated hyperbilirubinemia caused by defects in hepatic organic anion transporters. Unlike standard liver panels, this test confirms the genetic basis at the DNA level, sparing patients from invasive procedures such as liver biopsy.
| Feature | Our Test (NGS Precision) | Closest Alternative (Standard Liver Profile) |
|---|---|---|
| Target | Full SLCO1B3 + SLCO1B1 gene sequencing | Only conjugated bilirubin levels (indirect evidence) |
| Diagnostic Certainty | Confirms Rotor syndrome at DNA level | Excludes other hepatobiliary diseases; cannot confirm Rotor |
| Turnaround Time | 3–4 Weeks (ISO‑controlled process) | Same day (but lacks molecular confirmation) |
| Clinical Actionability | Definitive diagnosis, family screening, and genetic counselling | Serial monitoring, often requiring liver biopsy for differential |
Physician Insight & Safety Protocols
“Rotor syndrome is a benign, non‑progressive disorder, yet its clinical similarity to serious hepatic conditions often leads to anxiety and unnecessary investigations. This NGS‑based test provides the genetic clarity to rule out dangerous causes and reassure patients. A positive result must be correlated with fractionated bilirubin levels and imaging; do not guide therapy without phenotype confirmation. Always involve a genetic counsellor to discuss autosomal recessive inheritance and implications for family members.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory
Elevated bilirubin levels may alter the metabolism of certain medications. Patients undergoing concurrent pharmacotherapy should maintain all prescribed treatments unless explicitly instructed otherwise by their treating physician. The presence of Rotor syndrome does not warrant discontinuation of essential therapy. Always inform your doctor about your genetic test results to ensure integrated clinical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patient unable to provide informed consent; individuals requiring urgent inpatient care; inability to collect blood or DNA via FTA card; pregnancy (pre‑test counselling mandatory).
- Minors: Genetic testing complies with Federal Decree‑Law No. 4 of 2016 on Medical Liability — written consent from legal guardian and mandatory pre‑test genetic counselling are required.
- ER Red Flags: Seek immediate medical attention if you develop altered mental status, severe abdominal pain, deep jaundice with fever, or bleeding tendency. These are not indicators for this genetic test but require emergency evaluation.
- Acute liver failure symptoms supersede elective genetic testing.
Patient FAQ & Clinical Guidance
1. What exactly does the SLCO1B3 gene test detect?
Snippet Answer: This NGS test identifies pathogenic variants in the SLCO1B3 (and often SLCO1B1) genes that cause Rotor type hyperbilirubinemia, a hereditary conjugated jaundice.
Rotor syndrome results from biallelic mutations affecting organic anion transporting polypeptides, leading to impaired hepatic uptake of conjugated bilirubin. The test sequences all coding exons and splice sites, detecting point mutations, small insertions/deletions, and copy number variations. A positive result establishes the genetic diagnosis, eliminating the need for liver biopsy or extensive imaging. Genetic counselling is advised pre‑ and post‑test.
2. How does this test differ from a standard bilirubin panel?
Snippet Answer: The genetic test reveals the causative mutation at the DNA level, whereas routine bilirubin assays only measure conjugated bilirubin concentrations and cannot confirm the underlying aetiology.
Sequencing SLCO1B3/SLCO1B1 confirms that hyperbilirubinemia is hereditary and not due to biliary obstruction or hepatitis, thereby avoiding unnecessary liver biopsies. The test can also identify carriers among family members, a capability conventional biochemical tests do not provide.
3. Is home sample collection safe and how should I prepare?
Snippet Answer: Our DHA‑licensed mobile phlebotomist arrives with a temperature‑controlled kit; only a single drop of blood on an FTA card is needed — no fasting required.
The process meets ISO 9001:2015 and Federal Decree‑Law No. 4 of 2016 safety standards. The FTA card preserves DNA at room temperature during transport, and the entire collection takes less than 10 minutes. If you prefer venipuncture or extracted DNA, alternative collection options are available. Results are uploaded to a secure, PDPL‑compliant portal, and a teleconsultation with a genetic counsellor can be scheduled within 2 weeks of result delivery.
UAE Regulatory & Data Privacy Adherence
Data Protection: All genetic data is processed and stored in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety protocols adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Support: WhatsApp +971 54 548 8731 | 8 AM–11 PM daily. Reviewed by Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
Clinical & Logistical Metadata
| Test Name | SLCO1B3 Gene Hyperbilirubinemia (Rotor Type) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection — Peripheral Whole Blood (FTA Card or Venipuncture) |
| Methodology Used | Next‑Generation Sequencing (NGS) — Full Gene Sequencing |
| ICD‑10‑CM Code | E80.6, Z15.89, R17 |
| LOINC Code | 77735-7 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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