Test Price
2,800 AED✅ Home Collection Available
SLCO1B3 Gene Hyperbilirubinemia (Rotor Type) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SLCO1B3 لفرط بيليروبين الدم من نوع روتور في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary | ملخص تنفيذي
- ✓Accuracy: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next‑Generation Sequencing (NGS).
- ✓Premium Logistics: Hospital‑Grade Cold‑Chain Home Collection (8 AM‑11 PM) and VIP Mobile Phlebotomy.
- ✓Clinical Guidance: Complimentary telehealth post‑test interpretation with a clinical geneticist or gastroenterologist.
- ✓Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
دقة موثوقة:
يُوفّر هذا الاختبار الجيني تشخيصًا دقيقًا لمتلازمة روتور بنسبة حساسية تفوق 99.9% باستخدام تقنية التسلسل الجيني NGS المعتمدة وفقًا للمواصفة ISO 9001:2015. يتم سحب العينة منزليًا تحت ظروف نقل مبردة ومتوافقة مع المعايير السريرية، مع استشارة ما بعد الفحص عبر الهاتف لضمان فهم النتائج واتخاذ القرار الطبي المناسب. التحليل معتمد من هيئة الصحة بدبي ومتوافق مع أحكام المرسوم بقانون اتحادي رقم 41 لسنة 2024 وقانون حماية البيانات الشخصية PDPL.
Overview
The SLCO1B3 gene test by NGS comprehensively analyzes mutations associated with Rotor‑type hyperbilirubinemia, a hereditary, conjugated hyperbilirubinemia that mimics Dubin‑Johnson syndrome but is caused by defects in hepatic organic anion transporters. Unlike standard liver panels, this test confirms the genetic basis, sparing patients from invasive procedures. (يركز هذا الفحص على تأكيد المسبّب الجيني الوراثي بدقة عالية).
| Feature | Our Test (NGS Precision) | Closest Alternative (Standard Liver Profile) |
|---|---|---|
| Target | Full SLCO1B3 + SLCO1B1 gene sequencing | Only conjugated bilirubin levels (indirect evidence) |
| Diagnostic Certainty | Confirms Rotor syndrome at DNA level | Excludes other hepatobiliary diseases; cannot confirm Rotor |
| Turnaround Time | 3–4 Weeks (ISO‑controlled process) | Same day (but lacks molecular confirmation) |
| Clinical Actionability | Definitive diagnosis, family screening, and genetic counselling | Serial monitoring, often requiring liver biopsy for differential |
Clinical Insight from Dr. Prabhakar Reddy (DHA License: 61713011)
“Rotor syndrome is a benign, non‑progressive disorder, yet its clinical similarity to serious hepatic conditions often leads to anxiety and unnecessary investigations. This NGS‑based test provides the genetic clarity to rule out dangerous causes and reassure patients. A positive result must be correlated with fractionated bilirubin levels and imaging; do not guide therapy without phenotype confirmation. Always involve a genetic counsellor to discuss autosomal recessive inheritance and implications for family members.” — Dr. Prabhakar Reddy, Senior Gastroenterologist & Hepatologist.
Medication Safety Alert
Do not discontinue any prescribed medication without direct consultation with your treating physician. Elevated bilirubin may alter metabolism of certain drugs; however, Rotor syndrome does not require cessation of essential therapy. Always inform your doctor about your test results.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patient unable to provide informed consent; individuals requiring urgent inpatient care; inability to collect blood/DNA via FTA card; pregnancy (pre‑test counselling mandatory).
- Minors: Genetic testing complies with UAE CDS Law 2026 – written consent from legal guardian and mandatory pre‑test genetic counselling are required.
- ER Red Flags: Seek immediate medical attention if you develop altered mental status, severe abdominal pain, deep jaundice with fever, or bleeding tendency. These are not indicators for this genetic test but require emergency evaluation.
- Acute liver failure symptoms supersede elective genetic testing.
Frequently Asked Questions
Q: What exactly does the SLCO1B3 gene test detect?
Snippet Answer: This NGS test identifies pathogenic variants in the SLCO1B3 (and often SLCO1B1) genes that cause Rotor type hyperbilirubinemia, a hereditary conjugated jaundice.
Rotor syndrome results from biallelic mutations affecting organic anion transporting polypeptides, leading to impaired hepatic uptake of conjugated bilirubin. The test sequences all coding exons and splice sites, detecting point mutations, small insertions/deletions, and copy number variations. A positive result establishes the genetic diagnosis, eliminating the need for liver biopsy or extensive imaging. Genetic counselling is advised pre‑ and post‑test.
س: كيف يختلف هذا الاختبار عن تحسس البيليروبين التقليدي؟
إجابة مباشرة: يكشف الاختبار الجيني عن الطفرة المسبّبة وراثيًا، بينما تقتصر فحوصات البيليروبين الروتينية على قياس مستويات البيليروبين المقترن فقط ولا تؤكد أصل المرض.
يؤكد تسلسل جينات SLCO1B3/SLCO1B1 أن فرط بيليروبين الدم وراثي وليس ناتجًا عن انسداد القنوات الصفراوية أو التهاب كبدي، مما يُجنب المريض خزعات الكبد غير الضرورية. يمكن للفحص أيضًا تحديد الحاملين للمرض بين أفراد الأسرة، وهو ما لا توفره الاختبارات الكيميائية الحيوية.
Q: Is home sample collection safe and how do I prepare?
Snippet Answer: Our DHA‑licensed mobile phlebotomist arrives with a temperature‑controlled kit; only a single drop of blood on an FTA card is needed—no fasting required.
The process meets ISO 9001:2015 and Federal Law No. 41 of 2024 safety standards. The FTA card preserves DNA at room temperature during transport, and the entire collection takes less than 10 minutes. If you prefer whole blood or extracted DNA, alternative collection options are available. Results are uploaded to a secure, PDPL‑compliant portal, and a teleconsultation with a genetic counsellor can be scheduled within 2 weeks of result delivery.
UAE Regulatory Compliance: This is conducted under Federal Decree‑Law No. 41 of 2024 (Article 87), UAE PDPL, and CDS Law 2026 (Minors). Laboratory license: 9834453. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). LOINC: 77735-7. 2026 ICD‑10‑CM Codes: E80.6 (Rotor syndrome), Z15.89 (Genetic susceptibility), R17 (Hyperbilirubinemia).
Support: WhatsApp +971 54 548 8731 | 8 AM–11 PM daily. Reviewed by Dr. Prabhakar Reddy, DHA 61713011.
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