Test Price
2,800 AEDโ Home Collection Available
SLC7A7 Gene Lysinuric Protein Intolerance Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
This SLC7A7 Next-Generation Sequencing test delivers 99.9% diagnostic sensitivity for Lysinuric Protein Intolerance (LPI), enabling early dietary intervention and preventing irreversible organ damage. The test is processed under ISO 9001:2015 certified protocols with temperature-controlled logistics.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AMโ11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The SLC7A7 gene encodes the y+LAT1 amino acid transporter essential for dibasic amino acid absorption. Pathogenic variants in this gene cause Lysinuric Protein Intolerance (LPI), a rare autosomal recessive metabolic disorder affecting the liver, kidneys, and endocrine system. Our test uses Next-Generation Sequencing (NGS) with full exon coverage and CNV analysis to detect point mutations, small insertions/deletions, and copy number variations. Results are interpreted alongside plasma amino acid profiles and urinary orotic acid to confirm diagnosis.
| Feature | Our Test (SLC7A7 NGS) | Standard Single-Gene Sequencing |
|---|---|---|
| Precision | 99.9% sensitivity, full gene coverage | ~95%, limited regions |
| Method | Next-Generation Sequencing (NGS) + CNV analysis | Sanger sequencing |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
Physician Insight & Safety Protocols
โLysinuric protein intolerance can mimic common gastrointestinal or renal disorders. A positive genetic result must be correlated with plasma amino acids and urinary orotic acid, ideally under the guidance of a metabolic specialist. Early dietary protein restriction helps prevent hyperammonemic crises and renal complications. Family segregation studies are recommended for carrier detection.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
โ Medication Warning
Do not discontinue prescribed medications, including protein supplements or ammonia scavengers, without consulting your managing physician. Abrupt cessation may trigger acute metabolic decompensation.
Safety Exclusion Criteria & ER Red Flags
Exclusion Criteria
- Active severe infection or acute metabolic decompensation (delay test until stable).
- Inability to provide adequate DNA sample (severe leukopenia).
Emergency Red Flags
- Sudden onset of hyperammonemic crisis (confusion, vomiting, lethargy) โ seek emergency care immediately.
- Signs of acute liver failure (jaundice, coagulopathy).
- Severe protein aversion leading to malnutrition.
If you experience any of these, contact your physician or call emergency services before repeat testing.
Patient FAQ & Clinical Guidance
1. What is the clinical value of SLC7A7 NGS testing for suspected LPI?
SLC7A7 NGS testing identifies disease-causing mutations in the SLC7A7 gene to guide dietary management and medical interventions. It provides a definitive molecular diagnosis, differentiating LPI from other aminoacidurias or mitochondrial hepatopathies. The test covers all exons and exon-intron boundaries, detecting point mutations, small indels, and copy number variations, enabling personalized prognosis and family screening.
2. How should I prepare for this genetic test?
A mandatory comprehensive clinical history and pedigree charting by a certified genetic counselor before blood collection ensures accurate interpretation. No fasting is required. Provide details of any previous metabolic investigations, amino acid profiles, or imaging. Sample collection via home phlebotomy uses a single EDTA tube or FTA card.
3. How long does the test result take, and can it be used for insurance claims?
The turnaround time is 3 to 4 weeks. The final clinical report is issued in English and includes all necessary data for insurance reimbursement, including ICD-10 and LOINC codes. Our billing team assists with direct submission upon request.
4. Is home collection safe for a genetic test?
Yes. Our certified phlebotomists follow strict cold-chain protocols and use sterile EDTA tubes. The sample is transported to the laboratory within 4 hours under controlled temperature. Home collection is available daily from 8 AM to 11 PM.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
DNA Labs UAE operates under DHA Facility License Number 1143. All genetic data is handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic information is encrypted and stored on UAE-based servers with ISO 9001:2015 certified quality management (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | SLC7A7 Gene Full Sequencing โ Lysinuric Protein Intolerance (LPI) NGS Panel |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) with Copy Number Variation (CNV) Analysis |
| ICD-10-CM Code | E72.2 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License 1143 โ DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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