Test Price
2,800 AEDโ Home Collection Available
SLC5A5 Gene Sequencing for Thyroid Dyshormonogenesis Type 1 โ 2,800 AED
Executive Summary & Core Metrics
- TRUST 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM to 11 PM).
- Clinical Guidance: DHA-licensed genetic counsellor post-test tele-counselling included.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This test sequences the entire SLC5A5 gene using Next-Generation Sequencing (NGS) to detect pathogenic variants causing thyroid dyshormonogenesis type 1 (iodide transport defect). It is indispensable for endocrinologists, geneticists, and physicians managing congenital hypothyroidism in the UAE.
Comparison of NGS vs Sanger Sequencing
| Feature | Our Test (NGS Gold Standard) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) โ full gene coding regions & splice sites | Targeted Sanger sequencing โ limited to a few exons |
| Diagnostic Precision | >99.9% sensitivity & specificity for known pathogenic variants | ~95% (misses deep intronic/copy number variants) |
| Turnaround Time | 3โ4 weeks from sample receipt | 6โ8 weeks, often requiring multiple rounds |
| Genetic Counselling | Included pre- and post-test tele-counselling (DHA-licensed) | Rarely integrated; additional cost |
| UAE Regulatory Clearance | DHA-MOHAP approved; compliant with Federal Decree-Law No. 45 of 2021 (PDPL) and Federal Law No. 2 of 2019 (ICT in Health); ISO 9001:2015 cert. INT/EGQ/2509DA/3139 | Often lacks local accredited lab infrastructure |
Physician Insight & Safety Protocols
โAs a DHA-licensed consultant medical geneticist, I confirm that SLC5A5 gene sequencing provides definitive diagnosis for iodide transport defect, but results must be correlated with thyroid function tests and imaging. A negative result does not exclude all genetic causes of congenital hypothyroidism, and every case demands individual clinical correlation.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID 9294403
Advisory & Medication Safety
โ ๏ธ DO NOT discontinue prescribed thyroid hormone replacement (levothyroxine) or any other medication without consulting your doctor. This test is for diagnostic confirmation, not for medication adjustment.
Exclusion Criteria & Red Flags
- Exclusion: Individuals unable to provide informed consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability; minors without legal guardian consent. Home collection is not advised for patients on active anticoagulant therapy or with uncontrolled bleeding disorders.
- Red Flags: If you experience acute psychological distress, suicidal ideation, or panic attacks after receiving genetic results, immediately contact your crisis hotline or visit the nearest emergency department. Genetic results can be life-alteringโour post-test counselling includes a risk management plan.
Patient FAQ & Clinical Guidance
1. Who should consider this SLC5A5 gene test?
Individuals with congenital hypothyroidism of unknown etiology and low radioiodine uptake should consider SLC5A5 genetic testing to confirm an iodide transport defect.
2. What does the home collection process involve and how is my privacy protected?
Our DHA-licensed phlebotomist visits your home between 8 AM and 11 PM for a quick blood draw, ensuring cold-chain transport to our ISO-certified lab under strict UAE PDPL (Federal Decree-Law No. 45 of 2021).
3. How long until I receive results and what post-test support is available?
Results are released within 3โ4 weeks and include a mandatory telehealth session with a DHA-licensed genetic counsellor to explain the findings.
UAE Regulatory & Data Privacy Adherence
This service fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical consent and safety adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Operated under DHA Facility License No. 1143 at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. ISO 9001:2015 Certificate: INT/EGQ/2509DA/3139 ensures quality management.
Clinical & Logistical Metadata
| Test Name | SLC5A5 Gene Sequencing for Thyroid Dyshormonogenesis Type 1 |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Peripheral blood (whole blood in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) โ full gene coding regions and splice sites |
| ICD-10-CM Code | E07.1 |
| LOINC Code | 96728-9 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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