Test Price
2,800 AED✅ Home Collection Available
SLC12A2 Gene Next-Generation Sequencing – Bartter Syndrome Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM).
Clinical Guidance: Post-test telephonic counselling by DHA-licensed Medical Geneticist – Lina Osama Zaki Quteineh.
Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
What This Test Analyses
This Next-Generation Sequencing (NGS) test provides a comprehensive analysis of the entire SLC12A2 gene, which encodes the Na-K-2Cl cotransporter (NKCC1). Pathogenic variants in this gene cause Bartter syndrome type 1 (OMIM #601678), a rare autosomal recessive renal tubular disorder characterised by hypokalaemic metabolic alkalosis, hypercalciuria, and salt wasting. The test enables definitive molecular diagnosis, carrier detection, and informed family planning.
| Feature | Our NGS Full-Gene Test | Alternative: Sanger Single-Exon |
|---|---|---|
| Technology | Next-Generation Sequencing – all exons, intron-exon boundaries & promoter region | Sanger sequencing limited to pre-defined hotspot mutations |
| Diagnostic Precision | 99.9% analytical sensitivity; detects novel, rare, and splice-site variants | ~95% sensitivity; may miss novel or deep intronic mutations |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Cost (AED) | 2,800 | ~4,500 (limited coverage) |
Physician Insight & Safety Protocols
“A molecular diagnosis of Bartter syndrome requires careful correlation with clinical symptoms and electrolyte profiles. While NGS offers high sensitivity, I always stress a multidisciplinary approach involving nephrology and clinical genetics. Results should be discussed with your healthcare provider before any lifestyle or medication changes.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License No: 9294403
Important Medication Warning
Do not discontinue prescribed medications without consulting your doctor.
Abrupt changes to potassium-sparing diuretics, NSAIDs, or electrolyte supplements can trigger life-threatening arrhythmias or severe volume depletion in Bartter syndrome patients. Always consult your prescribing physician before altering any treatment.
Safety Exclusion Criteria & Red Flags
- Active bleeding disorder or anticoagulant therapy – consult your doctor before blood draw.
- Minors under 18 years require legal guardian consent per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Inability to provide adequate clinical history or three-generation family pedigree.
Emergency Red Flags
Seek immediate medical attention if you experience sudden muscle weakness, palpitations, fainting, or profound fatigue – these may indicate severe hypokalaemia or electrolyte crisis.
Patient FAQ & Clinical Guidance
1. What does this genetic test actually detect?
This NGS test identifies pathogenic mutations across the entire SLC12A2 gene, confirming Bartter syndrome at a molecular level. It also enables precise carrier risk assessment for family members.
2. How should I prepare for blood collection?
Complete a formal genetic counselling session, provide a detailed three-generation family pedigree, and maintain normal hydration. No fasting is required for this test.
3. Is this test approved by UAE health authorities?
Yes. The test is performed at DNA Labs UAE, a DHA-licensed facility (License No. 1143) under ISO 9001:2015, fully adherent to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning health information technology.
4. What is the turnaround time and sample requirement?
Turnaround time is 3–4 weeks after sample receipt. Acceptable sample types include whole blood (EDTA), extracted DNA, or one drop of blood on FTA card. A mandatory prerequisite is a completed clinical history and genetic counselling session.
5. Can I have the sample collected at home?
Yes, we offer VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection daily from 8 AM to 11 PM. Simply schedule via WhatsApp +971 54 548 8731.
UAE Regulatory & Data Privacy Adherence
Your Data, Protected by UAE Law
- All genetic data is processed strictly in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical consent and safety protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 certified facility ensures international standards of quality and data security.
For appointment booking or insurance verification, contact us on WhatsApp +971 54 548 8731 (8 AM – 11 PM, 7 days a week).
Clinical & Logistical Metadata
| Test Name | SLC12A2 Gene Next-Generation Sequencing (Bartter Syndrome) – Full Gene Analysis |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) – whole gene coverage |
| ICD-10-CM Code | E26.81 (Bartter syndrome) |
| LOINC Code | 94220-2 (Bartter syndrome gene panel) |
| DHA Facility License & Address | License: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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