Test Price
2,800 AED✅ Home Collection Available
SFTPB Gene Surfactant Metabolism Dysfunction Type 1 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Certified NGS processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The SFTPB Genetic Test screens for pathogenic variants in the SFTPB gene, the principal cause of surfactant metabolism dysfunction type 1 – a life-threatening neonatal lung disease. This test utilizes Next Generation Sequencing (NGS) to deliver comprehensive coverage and detect even low-level mosaic mutations, ensuring early diagnosis and targeted clinical management. Pre-test genetic counselling and a detailed family pedigree are mandatory prior to sample collection to ensure accurate risk assessment and variant interpretation.
| Feature | Our Test (SFTPB NGS) | Sanger Sequencing (Single-Gene) |
|---|---|---|
| Precision / Analytical Sensitivity | >99.9% (detects mosaic variants ≤5%) | ~95% (may miss low-level mosaicism) |
| Methodology | Next Generation Sequencing (NGS) | Sanger Sequencing |
| Turnaround Time | 3 to 4 Weeks | 3 to 4 Weeks |
| Price (AED) | 2800 | ~2000 (limited comprehensive analysis) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): As a clinical geneticist, I emphasize that this NGS test provides comprehensive analysis of the SFTPB gene, but results must be correlated with clinical presentation, imaging findings, and family history. A negative result does not exclude all genetic etiologies of surfactant dysfunction, and a positive result demands immediate multidisciplinary evaluation. I strongly recommend that all patients discuss their results with a pediatric pulmonologist and a clinical geneticist to formulate a personalized care plan.
Advisory: Safety and Consent
⚠️ Patient Safety:
Sample collection must be performed by a certified phlebotomist. All procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Informed consent is required prior to testing. Results should be interpreted only by a qualified medical geneticist. Do not discontinue any prescribed medication without consulting your treating physician.
Exclusion Criteria & Emergency Red Flags
- Inability or unwillingness to undergo pre-test genetic counselling.
- Hemolyzed, clotted, or insufficient sample volume – recollection will be required at no extra fee.
- Minors (under 18 years) must have parental consent in compliance with UAE Federal Law No. 2 of 2019.
- ER Red Flags: Acute respiratory distress, cyanosis, grunting, nasal flaring, severe retractions, apnea, failure to thrive, or any sign of impending respiratory failure. Seek immediate emergency medical attention.
Patient FAQ & Clinical Guidance
1. What is the SFTPB NGS test used for?
Direct Answer: The SFTPB NGS test detects pathogenic mutations in the surfactant protein B gene to diagnose or rule out surfactant metabolism dysfunction type 1, a severe neonatal respiratory disorder.
Surfactant dysfunction type 1 leads to life-threatening respiratory failure in newborns. Early identification of SFTPB variants enables timely management, including potential lung transplantation or supportive care. The test is recommended for infants with unexplained respiratory distress, family history of the disease, or for carrier screening in at-risk families.
2. How is the sample collected for this test?
Direct Answer: A small blood sample, extracted DNA, or a single drop of blood on a specialized FTA card is collected by a certified phlebotomist in the comfort of your home.
Our premium home collection service operates from 8 AM to 11 PM and uses cold-chain logistics to preserve DNA integrity. You do not need to visit a lab; the entire process is rapid, minimally invasive, and compliant with UAE healthcare regulations.
3. What does a positive SFTPB result mean?
Direct Answer: A positive result confirms the presence of a disease-causing variant in the SFTPB gene, indicating a high probability of developing surfactant deficiency that requires immediate specialist evaluation.
A positive should always be interpreted together with clinical symptoms and family history. It may guide therapy options, eligibility for clinical trials, or early referral for lung transplantation. Genetic counseling will explain inheritance patterns (autosomal recessive) and implications for future pregnancies.
UAE Regulatory & Data Privacy Adherence
Legal Compliance
This test is performed in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability
All patient data is encrypted and handled in accordance with international standards. Results are shared only with the requesting physician and patient.
Clinical & Logistical Metadata
| Test Name | SFTPB Gene Surfactant Metabolism Dysfunction Type 1 Genetic Test (NGS) |
| Price (AED) | 2800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card Blood Spot |
| Methodology Used | Next Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | P27.0 (Neonatal surfactant deficiency) |
| LOINC Code | 93239-9 (SFTPB gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA License: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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