Test Price
2,800 AED✅ Home Collection Available
SERPIN1 Gene Familial Encephalopathy with Neuroserpin Inclusion Bodies Genetic Test in UAE | 2,800 AED | Next-Generation Sequencing
Executive Summary & Core Metrics
Diagnostic Accuracy: 99.9% sensitivity for SERPIN1 pathogenic variants via ISO 15189 accredited targeted NGS with deep coverage >500×. Collection Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM) for standard peripheral blood, or archival DNA extraction. Clinical Guidance: Telephonic post-test interpretation by a Consultant Medical Geneticist. Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This targeted Next-Generation Sequencing (NGS) test examines the entire coding region and splice sites of the SERPIN1 gene to diagnose familial encephalopathy with neuroserpin inclusion bodies (FENIB) — a rare, adult-onset neurodegenerative disorder caused by toxic accumulation of mutant neuroserpin protein. The methodology includes comprehensive copy number variant (CNV) analysis and detects point mutations, small insertions/deletions, and exon-level deletions or duplications with high analytical validity.
| Parameter | Our Test (SERPIN1 Targeted NGS) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | 99.9% sensitivity for SERPIN1 variants; deep coverage >500×, including intronic boundaries | Often lower depth (<100×) for this gene; may miss regulatory or deep intronic variants |
| Methodology | Targeted NGS panel with CNV analysis (LC‑MS/MS not applicable) | Whole Exome Sequencing without dedicated SERPIN1 optimisation |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I emphasise that while this SERPIN1 NGS test provides a precise molecular diagnosis, its results must be integrated with a comprehensive neurological assessment, detailed family history, and pre-test genetic counselling. The identification of a pathogenic variant has profound implications for the patient and their at-risk relatives. No single test replaces clinical judgement.”— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notes
Medication Caution: Do not discontinue any prescribed neurological or psychiatric medication without explicit guidance from your treating physician. Test results do not replace ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- Inability or refusal to provide a blood sample after informed consent (mandatory per Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Minors (<18 years) without legal guardian consent — strictly prohibited under UAE Federal Law.
- Acute severe illness or haemodynamic instability at the time of sample collection (risk of vasovagal syncope).
- If you experience sudden worsening of gait, confusion, or seizures, seek emergency medical care immediately — do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the SERPIN1 gene test used for?
This advanced NGS test detects pathogenic mutations in the SERPIN1 gene responsible for familial encephalopathy with neuroserpin inclusion bodies (FENIB), enabling accurate diagnosis, family cascade screening, and informed reproductive planning.
2. How is the sample collected and what is the turnaround time?
A simple peripheral blood draw (2–5 mL in EDTA tube) or a dried blood spot on an FTA card is collected. Our VIP mobile phlebotomist can visit your home or office daily from 8 AM to 11 PM with temperature-controlled transport. Results are reported in 3 to 4 weeks from sample receipt.
3. Is this covered by my UAE health insurance?
Most UAE insurers cover genetic testing when medically necessary. Contact our support via WhatsApp at +971 54 548 8731 for instant direct billing verification and pre-authorisation assistance.
4. What does a positive result mean for my family?
A pathogenic variant in SERPIN1 indicates a 50% risk of inheritance for each first-degree relative. We recommend genetic counselling and targeted testing for at-risk family members. Our Consultant Medical Geneticist can guide you through the process.
UAE Regulatory & Data Privacy Adherence
This test is performed under the regulatory framework of the Dubai Health Authority (DHA) and complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, anonymised, and stored in UAE-based servers with strict access controls. Clinical safety and patient consent follow Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | SERPIN1 Gene Sequencing (Familial Encephalopathy with Neuroserpin Inclusion Bodies) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral blood (EDTA), dried blood spot (FTA card), or extracted genomic DNA |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) with CNV analysis |
| ICD-10-CM Code | G31.89, G31.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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