Test Price
2,800 AEDโ Home Collection Available
SEMA3A Gene (Kallmann Syndrome) Sequencing Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity โ ISO 9001:2015 Certified Protocol. Exclusive VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM). Free Post-Test Telephonic Clinical Guidance by a DHA-Licensed Consultant Medical Geneticist. Direct Insurance Billing Verification via WhatsApp +971 54 548 8731.
This advanced genetic test provides high diagnostic accuracy for identifying SEMA3A gene mutations associated with Kallmann syndrome, with DHA-licensed home collection and regulatory compliance under UAE Personal Data Protection Law (PDPL).
Test Overview & Methodology
The SEMA3A Gene Sequencing Test analyzes the entire coding region of the SEMA3A gene using Next-Generation Sequencing (NGS) to identify pathogenic variants associated with Kallmann syndromeโa congenital disorder characterized by hypogonadotropic hypogonadism and anosmia. This comprehensive genetic analysis delivers precise mutation detection to aid clinicians in early diagnosis and therapeutic decision-making for Kallmann syndrome.
| Feature | Our SEMA3A NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Technology | Full Gene NGS (all exons and splicing sites) | Sanger (limited to selected exons) |
| Variant Detection | Greater than 99.9% for SNVs, small indels, CNVs | Approximately 95% for targeted regions only |
| Turnaround Time | 3 to 4 Weeks | 2 to 3 Weeks |
| Clinical Utility | Comprehensive for reproductive and endocrine planning | Limited; may miss atypical mutations |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): "As a Consultant Medical Geneticist, I emphasize that a positive genetic result for SEMA3A should always be interpreted in conjunction with comprehensive endocrine evaluation, family history, and clinical phenotyping. Although this test provides robust diagnostic clarity, it is not a substitute for a complete clinical assessment by a specialist. Your healthcare journey is our priority, and we are here to guide you through every step of the diagnostic and counseling process."
Advisory Notice
Medication Caution
Do not discontinue prescribed hormone replacement therapy or any prescribed medication without consulting your treating physician.
Exclusion Criteria and Safety Red Flags
- Not for minors without legally valid parental consent as per UAE Federal Law.
- Individuals unable to provide written informed consent independently.
- Acute febrile illness requiring urgent medical intervention โ postpone sample collection until resolved.
- Emergency Red Flags: If you experience sudden severe headache, visual loss, or neurological deficits, seek emergency care immediately. These symptoms are unrelated to the test and require urgent evaluation.
Patient FAQ & Clinical Guidance
1. What is the purpose of the SEMA3A gene test?
This genetic analysis detects pathogenic SEMA3A gene variants causing Kallmann syndrome, enabling definitive molecular diagnosis and guiding targeted endocrine management and reproductive counseling.
2. How is the sample collected for this test?
A DHA-licensed phlebotomist collects a small peripheral blood sample from your arm at your home via our VIP Mobile Phlebotomy service, using ISO-certified temperature-controlled cold-chain transport to ensure sample integrity.
3. What can I expect from the results and follow-up care?
Your report details SEMA3A gene variants with clinical interpretation and pathogenicity classification, followed by a telephonic consultation with a DHA-licensed Consultant Medical Geneticist to discuss implications and next steps.
4. How long does it take to receive the results?
The standard turnaround time is 3 to 4 weeks from sample collection, allowing for thorough sequencing, bioinformatic analysis, and clinical validation.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
This test is performed under the regulatory oversight of the Dubai Health Authority (DHA) and adheres to UAE federal data protection and healthcare standards.
- Data Protection: All personal health information is processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Data Governance: Electronic health records and genetic data are handled according to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety & Consent: Patient safety and informed consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- DHA Licensing: DNA Labs UAE is fully licensed by the Dubai Health Authority under Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | SEMA3A Gene (Kallmann Syndrome) Sequencing Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Analysis |
| ICD-10-CM Code | E23.0 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians