Test Price
2,800 AED✅ Home Collection Available
SDHA Gene Leigh Syndrome Genetic Test in UAE | 2800 AED | DHA Guidelines
Executive Summary & Core Metrics
Clinical Excellence Guarantee
- 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS platform (Cert: INT/EGQ/2509DA/3139).
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection: Available daily from 8 AM to 11 PM.
- Post-Test Clinical Guidance: Telephonic result interpretation by Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA-9294403).
- Insurance Integration: Direct billing verification via WhatsApp at +971 54 548 8731.
This test ensures the highest diagnostic accuracy per international standards and DHA guidelines, with complete pre- and post-test genetic counseling.
Test Overview & Methodology
The SDHA Gene Leigh Syndrome NGS test is a comprehensive next-generation sequencing assay that analyzes the entire coding region and splice junctions of the SDHA gene, detecting single nucleotide variants, insertions/deletions, and copy number variations (CNVs) with deep coverage. This test is essential for confirming a clinical suspicion of Leigh syndrome, guiding targeted therapy, and enabling accurate family risk assessment.
| Feature | Our Test (NGS Full Gene + CNV) | Closest Alternative (Targeted Panel) |
|---|---|---|
| Methodology | Illumina NovaSeq + ACMG 2025 variant interpretation | Sanger sequencing of selected exons |
| Sensitivity | >99.9% for all variant types | ~85% (misses large deletions/CNVs) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Sample Requirement | Blood, Extracted DNA, or Dried Blood Spot (FTA Card) | Blood only |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Genetics (License: 9294403), I emphasize that this NGS test provides high-resolution genotyping of the SDHA gene. However, a pathogenic variant report must always be correlated with the patient’s clinical phenotype, brain MRI findings, and biochemical markers (e.g., elevated lactate/pyruvate ratio). A negative result does not rule out other mitochondrial disorders or complex II deficiency due to alternative genes. Please use this information in conjunction with your neurologist or metabolic specialist’s evaluation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA: 9294403
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Acute metabolic decompensation or critical illness requiring immediate medical stabilization. Test should be postponed until the patient is clinically stable.
- Exclusion: Inability to provide informed consent (mandatory genetic counseling).
- ER Red Flag: Sudden onset of seizures, loss of consciousness, or stroke-like episodes—seek emergency care immediately; do not delay for this outpatient genetic test.
- ER Red Flag: Rapid neurological deterioration in a child suspecting Leigh syndrome—this test is not intended for acute diagnosis; urgent metabolic workup is required first.
Do not discontinue prescribed medication without consulting your doctor.
Patient FAQ & Clinical Guidance
1. What exactly does the SDHA Gene Leigh Syndrome NGS test detect?
This sequences the entire SDHA gene using next-generation sequencing to identify pathogenic mutations that cause Leigh syndrome, a severe mitochondrial disorder.
2. How is the sample collected and is a hospital visit required?
A DHA-licensed phlebotomist visits your home or office (8 AM – 11 PM) via our VIP Mobile Phlebotomy service to collect a simple blood sample or a finger-prick dried blood spot on an FTA card. No hospital visit is required.
3. How long will it take to receive my results and what do they include?
Your comprehensive report, including variant classification according to ACMG 2025 standards, clinical interpretation, and genetic counseling recommendations, is delivered within 3–4 weeks.
4. Will insurance cover this test?
We can verify your insurance coverage directly via WhatsApp at +971 54 548 8731. Many DHA-approved plans cover genetic testing for confirmed clinical indications such as suspected Leigh syndrome.
UAE Regulatory & Data Privacy Adherence
This test is performed in compliance with the following UAE federal regulations:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring the confidentiality and security of your genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing the use of digital health platforms and telemedicine.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – establishing the rights and safety standards for clinical assessment and patient consent.
Our laboratory is DHA-licensed under Facility License No. 1143 and ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | SDHA Gene Leigh Syndrome NGS Sequencing & CNV Analysis |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood, extracted DNA, or dried blood spot (FTA card) |
| Methodology Used | Next-Generation Sequencing (Illumina NovaSeq) with CNV analysis |
| ICD-10-CM Code | G31.81 (Leigh syndrome) |
| LOINC Code | 95219-5 (SDHA gene full sequencing) |
| DHA Facility License & Lab Address | DNA Labs UAE - DHA License No. 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians