Test Price
2,800 AED✅ Home Collection Available
SALL4 Gene Analysis for Duane Retraction Syndrome (Genetic Test) in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين SALL4 لمتلازمة انحسار دوان في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
دقة تشخيصية مضمونة بنسبة 99.9% عبر معالجة مخبرية معتمدة بمعيار ISO، مع حماية كاملة للبيانات الجينية وفقاً لقانون حماية البيانات الشخصية الإماراتي.
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- ✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy.
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a genetic counsellor.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Clinical Overview
This next‑generation sequencing (NGS) test analyses the complete coding sequence of the SALL4 gene to identify pathogenic variants responsible for Duane retraction syndrome and the broader Okihiro spectrum. It is the definitive molecular diagnostic tool for confirming hereditary eye movement disorders and guiding multidisciplinary care. يُعد تحليل التسلسل الجيني الكامل لجين SALL4 الأداة التشخيصية الجزيئية النهائية لتأكيد اضطرابات حركة العين الوراثية.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Technology | Next‑Generation Sequencing (targeted panel) | Sanger Sequencing (single gene) |
| Sensitivity for SNVs/Indels | 99.9% | ~95% |
| Copy Number Variation Detection | Detected (MLPA complement) | Not available |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| International Accreditation | ISO 9001:2015 & DHA Licensed | May lack ISO certification |
Physician Insight & Safety Protocol
“As a specialist in genetic eye diseases, I understand that a diagnosis of Duane retraction syndrome can raise many questions. This test offers definitive molecular confirmation, allowing us to tailor management and provide accurate genetic counselling. Please remember that results must be interpreted alongside your full clinical history – never in isolation.”
– Dr. Prabhakar Reddy, Consultant Ophthalmologist (DHA License: 61713011)
⚠ Clinical Note
Do not discontinue any prescribed medication or therapy without prior consultation with your treating physician. Genetic test results provide risk assessment, not therapeutic directives.
- • Exclusion Criteria: Active febrile illness, acute eye infection, or inability to provide informed consent (minors must have legal guardian consent per UAE CDS Law 2026).
- • ER Red Flags: If you experience sudden vision loss, severe eye pain, or acute neurological symptoms, seek emergency medical attention immediately; these are unrelated to routine genetic testing.
- • Mandatory pre‑test genetic counselling session to draw a pedigree chart of affected family members.
Frequently Asked Questions
What is the SALL4 gene and how does it relate to Duane retraction syndrome?
Snippet: The SALL4 gene encodes a transcription factor critical for eye and limb embryonic development; pathogenic variants cause Duane retraction syndrome, often with radial ray anomalies. (15 words)
Duane retraction syndrome (DRS) is a congenital cranial dysinnervation disorder where the lateral rectus muscle does not develop properly. About 20% of familial cases are linked to heterozygous mutations in SALL4, which also underlies Okihiro syndrome (Duane‑radial ray syndrome). This NGS test screens all exons and flanking intronic regions to detect single‑nucleotide variants, small deletions/insertions, and, with complementary MLPA, copy number changes.
جين SALL4 يشفّر عامل نسخ حيوي لنمو العين والأطراف، وطفراته تسبب متلازمة انحسار دوان مع تشوهات الشعاع الكعبري.
How should I prepare for the SALL4 gene test?
Snippet: No fasting is required; your clinical history and a genetic counselling session to draw a family pedigree are mandatory before sample collection. (15 words)
A small blood sample (3–5 mL in EDTA tube) or a drop of blood on an FTA card is sufficient. If you have previously extracted DNA stored in a reputable biobank, that can also be used. The laboratory will provide a cold‑chain phlebotomy service at your home. Please inform the team of any bleeding disorders or anticoagulant medication. A pre‑ genetic counselling session is compulsory to understand inheritance patterns and to construct a detailed pedigree, as required by UAE Federal Decree‑Law No. 41 of 2024.
لا يُشترط الصيام؛ لكن يجب تقديم التاريخ المرضي الكامل وحضور جلسة استشارة وراثية لرسم شجرة العائلة قبل سحب العينة.
Will my genetic data be kept confidential under UAE law?
Snippet: Absolutely; all genomic data is encrypted and processed under UAE Personal Data Protection Law and Federal Decree‑Law No. 41 of 2024. (15 words)
Our facility adheres to strict PDPL guidelines and ISO 9001:2015 quality management. Genetic information is de‑identified and shared only with the referring physician. Results are never disclosed to third parties without your explicit written consent. For minors, the Child Digital Safety (CDS) Law 2026 mandates that genetic counselling and informed consent involve the legal guardian.
بياناتك الجينية مشفرة بالكامل وتُعالج وفق قانون حماية البيانات الشخصية الإماراتي والمرسوم الاتحادي رقم 41 لعام 2024.
UAE Legal Compliance: Federal Decree‑Law No. 41 of 2024, Art. 87 on Medical Liability; UAE Personal Data Protection Law; CDS Law 2026 (Minors). | Facility License: 9834453 | ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
LOINC: 21705-3 | ICD‑10‑CM: Z13.71, H50.813, Q87.0
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